1005: David Fajgenbaum | Leveraging AI to Cure Rare Diseases

Tim Grover is the preeminent authority on the science and art of achieving physical and mental dominance relied upon by legendary athletes like Michael Jordan and Kobe Bryant at the top of their game. He's also an author, and his latest book is Winning: The Unforgiving Race to Greatness. What We Discuss with Tim Grover: Putting aside inspirational Internet meme bromides, what does it really mean to be relentless? Why you can't even access the upper limits of the physical without putting the mental blocks in place first. Why the intangibles -- like commitment and resilience -- are more important than the measurable -- like strength and speed. The paradigm-shifting thought patterns that go into becoming a world-class champion. Why top performers aren't looking for motivation -- they're looking for elevation. And much more... Full show notes and resources can be found here: jordanharbinger.com/506 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Maj 20211h 20min

Your adult son has Asperger Syndrome, which has contributed to his naïveté in social situations and led to others taking advantage of him. Now he's married to a woman who has served time in prison for smothering her own mother with a pillow and attempted to do the same to her ex-husband. On top of this concerning history, she also falsely accused your son of rape and assault when he tried to leave her. What can you do for your special needs son who's been seduced by this psycho siren? We'll try to find answers to this and more here on Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/505 On This Week's Feedback Friday, We Discuss: Your adult son with special needs has been tricked into marriage with a legitimate psycho killer and accused by her of rape and assault when he tried to end it. How can you help him pry free from this murderous harpy before it's too late? [Thanks to attorney Corbin Payne, Surrounded by Psychopaths author Thomas Erikson, and clinical psychologist Dr. Erin Margolis for helping us field this one!] How do you politely decline an offer to "catch up" with an old co-worker who doesn't seem to understand that you never particularly cared for them? After doing a payscale salary comparison, you estimate that you make $15-20k less than the median salary for your qualifications. Would it be best for you to attempt to negotiate a raise at your current job, or bite the bullet and try to find a new job with better pay? Your usually non-dramatic wife has taken to breaking into tears for seemingly no reason at least once a week or so (that you know of). Could it be due to her obsession with picture-perfect Instagram influencers making her feel bad about herself? Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Maj 202152min

Lt. Col. Oliver North (@OliverLNorth) is a political commentator, military historian, and retired United States Marine Corps lieutenant colonel. He is the author of many leather-bound books, and the host of Oliver North's America and Oliver North's Real American Heroes. What We Discuss with Oliver North: An Oliver North's-eye view of the Iran–Contra affair after 30+ years in the rearview mirror. Using SMEAC (Situation, Mission, Execution, Admin and Logistics, and Command and Signal) for making decisions in high-pressure situations. Why Oliver still recalls one day as a Marine machine-gunner during the Vietnam conflict as the worst in his life. What it's like to survive an assassination attempt (and outlive its bumbling perpetrators). Why Oliver considers "servant leaders" to be the best leaders. And much more... Full show notes and resources can be found here: jordanharbinger.com/504 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Maj 20211h 11min

Cal Newport researches cutting-edge technology and writes about the impact of these innovations on society. He is the New York Times bestselling author of Deep Work, So Good They Can’t Ignore You, Digital Minimalism, and his latest, A World without Email: Reimagining Work in an Age of Communication Overload. What We Discuss with Cal Newport: What is the hyperactive hive mind, and how did the collaborative nature of email communication give rise to it? Why checking our email an average of every six minutes is, as Cal puts it, "a terrible way to extract value from human neurons." How so-called multitasking takes its toll not only on our individual capacity to focus, but on the prosperity of society as a whole. Why debuzzing the hyperactive hive mind can't be done from the inbox, but by replacing the rules for how we collaborate. How we can set the rules, guidelines, and systems by which we agree to communicate without succumbing to the collective pull of the hyperactive hive mind. And much more... Full show notes and resources can be found here: jordanharbinger.com/503 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Maj 20211h 15min

The father of your eight-year-old daughter has been given six months to live. How much do you tell your daughter -- and how soon? We'll try to find answers to this and more here on Feedback Friday. And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/502 On This Week's Feedback Friday, We Discuss: The father of your eight-year-old daughter has been given six months to live. How much do you tell your daughter -- and how soon? [Thanks to clinical psychologist and friend Erin Margolis for helping us with this one!] Career circumstances drove you and your ex-girlfriend apart a few years ago. And while she thinks you and her new fiance would be fast friends, you don't need a constant reminder of what might have been. How do you get her to respect your boundaries on this matter? A recruiter told you that a misdemeanor DUI from 2013 makes your chance of becoming an Air Force officer "nearly zero," but it's a dream you've had since you were seven. You couldn't forgive yourself for not giving it a shot anyway, but are you just wasting your time? [Thanks to Evil Genius Jason LeDuc for helping us field this one!] You've been on a revolving door basis with college admissions for years, never really nailing down a course plan that suits you before you drop out and try something else. You've spent countless hours and dollars without credentials to begin a professional career, much to your parents' shame as well as your own. How can you just choose a path and stick to it? Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please...See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Apr 202148min

Ed Calderon (@eds_manifesto) is a non-permissive environment specialist and combatives instructor with over 10 years of experience in counter-narcotics, organized crime investigation, and public safety in the northern border region of Mexico. [This is part two of a two-part episode. Find part one here!] What We Discuss with Ed Calderon: Three things that kept Ed from choosing the cartel life over law enforcement when it became a very real option. Why there’s an eerie devotion to blasphemous, Church-condemned figures like death icon La Santa Muerte by the dispossessed and the deadly on both sides of the law. What happens when different factions of law enforcement in the same area work for different cartels. How occult practices that combine Catholic symbology with Aztec beliefs adapt to changing times and desperate characters. Is Ed worried for his life after crossing some of the world’s most dangerous and vindictive people? And much more… Full show notes and resources can be found here: jordanharbinger.com/501 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Apr 202147min

Ed Calderon (@eds_manifesto) is a non-permissive environment specialist and combatives instructor with over 10 years of experience in counter-narcotics, organized crime investigation, and public safety in the northern border region of Mexico. [This is part one of a two-part episode. Stick around for part two later this week!] What We Discuss with Ed Calderon: How drug cartels infiltrate and take over towns, cities, and entire regions without fearing local law enforcement or even the military. How US taxpayers fund limitless government corruption south of the border without any real accountability. 2020 has been the most deadly year in Mexico for cartel-related violence, and it's getting worse. Not all mass graves found in Mexico are the result of cartel atrocities. The reality could be even more sinister. Why cracking down on cartel crime is such a difficult (and life-threatening) proposition for would-be crusaders. And much more... Full show notes and resources can be found here: jordanharbinger.com/500 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Apr 202143min

You're in a relationship with someone who's in an open marriage and all parties consent -- for now. But you want to be sure you don't get stuck with your state's tricky alien of affection law that could ruin your life if someone changes their mind. Aside from documenting all communication, how can you best prepare a polyamorous protection plan should your love triangle get bent out of shape and leave you and your property legally in peril? We'll tackle this and more here on Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/499 On This Week's Feedback Friday, We Discuss: How can you best prepare a polyamorous protection plan should your love triangle get bent out of shape and leave you and your property legally in peril? [Thanks again to attorney and friend Corbin Payne for helping us with this one!] Your intense, old-fashioned dad doesn't approve of your brother's girlfriend, which makes the arrival of their first child (and his first grandchild) somewhat bittersweet. On top of all this, he's hurt he was the last to find out. What can you do to facilitate communication between your dad and brother so this doesn't sour what should really be a happy occasion for the family? How do you remain professional and open to networking when you've got annoying, creepy, and clueless clients abusing your business relationship as an unwelcome excuse to pursue something more intimate? With some of our episodes including less-than-complimentary critiques about the governments of North Korea and China, are we ever worried about being targeted by their agents, and would we ever travel to either country again? Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Apr 202147min