Addiction Audio14 Aug 2022

Opioid agonist treatment, drug related deaths and dynamic models with Matt Hickman

In this episode, Professor Matt Hickman talks about using population modelling to identify the population implications of Opioid Agonist Treatment (OAT). He covers the impact that OAT has on drug-related deaths and other causes of mortality as well as how models can be used to explore what mortality rates would have been without OAT in New South Wales, Australia.

Professor Hickman talks about their findings that, without OAT, the number of overdose deaths would have been 50% higher.

“So, what we were trying to do in this study was to model the counter-factual of how many deaths there would be if there hadn’t been any opioid agonist treatment. In theory the ideal model would be a trial in which you have OAT versus no OAT in a population, now clearly that’s unethical and can’t be done.”

He also talks about how the research team set up a dynamic model that they used to explore the data, matching incarceration and OAT records. They then used those data alongside findings from systematic reviews to model the hypothetical impact of OAT on a real population.

“We’ve done models before, theoretical models which say ‘if we increase the opioid agonist treatment programme and we increase duration at a certain point what impact would that have?’ but that’s rarely based on actual real data. So …there’s modelling and there’s modelling, and this model is based on real empirical data and we think that gives it a bit more credence”.

Original paper here: Modeling the population-level impact of opioid agonist treatment on mortality among people accessing treatment between 2001 and 2020 in New South Wales, Australia by Antoine Chaillon and colleagues. Published in Addiction (2022)

Hosted on Acast. See acast.com/privacy for more information.

Det här avsnittet är hämtat från ett öppet RSS-flöde och publiceras inte av Podme. Det kan innehålla reklam.

Avsnitt(144)

Cannabis, cognition, and the role of nicotine with Emese Kroon

In this episode, Dr Tsen Vei Lim talks to Dr Emese Kroon. Emese is a postdoctoral researcher at the Center for Substance Use and Addiction Research at the Erasmus University Rotterdam in the Netherlan...

4 Sep 20min

What young people see online about illicit vaping with Eleanor Bray

In this episode, Dr Annika Theodoulou speaks to Eleanor Bray, a research associate at the University of East Anglia, UK. The interview covers Eleanor’s research article covering a content analysis of ...

28 Aug 18min

Redefining success in cannabis use disorder treatment with Toby Atkin

In this episode, Dr Elle Wadsworth talks to Dr Tobias (Toby) Atkin, psychiatrist and a research fellow in Addiction Psychiatry at Columbia University in the US. The interview covers Toby’s opinion and...

21 Aug 17min

What we know about alcohol risk in 2026 with Sinclair Carr and Jürgen Rehm

In this episode, Dr Tsen Vei Lim talks to Sinclair Carr and Dr Jürgen Rehm. Sinclair is a PhD candidate at the Harvard T.H. Chan School of Public Health in the US, and Jürgen is a Senior Scientist at ...

14 Aug 26min

School-aged outcomes after prenatal opioid exposure with Louise Marryat

In this episode, Dr Elle Wadsworth talks to Dr Louise Marryat, a senior research fellow at the University of Glasgow, Scotland. The interview covers Louise’s systematic review on prenatal opioid expos...

7 Aug 18min

Using brain stimulation to treat alcohol use disorder with Anastasia Demina

In this episode, Dr Tsen Vei Lim talks to Dr Anastasia Demina, an addiction physician and researcher at the Dijon Bourgogne University Hospital and Université Bourgogne Europe, France. The interview ...

31 Juli 20min

Tracking trends in new psychoactive substance poisonings with Annette Nugteren-van Lonkhuyzen

In this episode, Dr Elle Wadsworth talks to Annette Nugteren-van Lonkhuyzen, a PhD student and toxicologist at the Dutch National Poisons Information Centre in Utrecht, the Netherlands. The interview ...

24 Juli 18min

The next chapter of cannabis regulation in Thailand with Rasmon Kalayasiri

In this episode, Dr Elle Wadsworth talks to Professor Rasmon Kalayasiri, Head of the Department of Psychiatry at the Faculty of Medicine, Chulalongkorn University, Thailand. The interview covers Rasmo...

17 Juli 18min