Semaglutide for the People

Semaglutide for the People

Ozempic has been hailed as a miracle drug. It is the most well known of the GLP-1 medications, a class of drugs that can help regulate appetite, digestion, and blood sugar—and help those suffering from obesity or diabetes lose weight. Naturally, these drugs are very much in demand. But now there is a shortage of Ozempic and other GLP-1s, which has led to a swell of clones that purport to offer the same benefits and the same key ingredient, semaglutide, at lower prices. These clone drugs are easy to procure from telehealth providers, even if a buyer needs to lie about themselves a little bit to buy them.

In this brave new weight-loss world, we're still coming to grips with how these drugs fit into our society. Part of that journey is the continued study about how GLP-1 drugs work—much of how they affect us is still unknown—and the continued debate about how much we should regulate and control their use.

This week on Gadget Lab, we talk with WIRED writers Kate Knibbs and Emily Mullin about how GLP-1 medications like Ozempic work and what happens when they don’t. We also talk about the current drug shortage and how that may get resolved.

Show Notes:

Read Kate’s story about buying cloned Ozempic online. Read Emily’s story about how Ozempic doesn’t work for everyone. Read all the stories in WIRED’s The Age of Ozempic series.

Recommendations:

Emily recommends staying cool this summer however you can. Kate recommends the HBO series John Adams, starring Paul Giamatti. Mike recommends buying a used 35-mm film camera and shooting some rolls to flex your creativity.


Kate Knibbs can be found on social media @Knibbs. Emily Mullin is @emilylmullin. Michael Calore is @snackfight. Lauren Goode is @LaurenGoode. Bling the main hotline at @GadgetLab. The show is produced by Boone Ashworth (@booneashworth). Our theme music is by Solar Keys.

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Meta’s Sound and Vision

Meta’s Sound and Vision

Undeterred by its many detractors, Meta is still trying to make the metaverse happen. This week, the company held its annual Connect developer conference at its headquarters in Menlo Park, California. Meta CEO Mark Zuckerberg took to the stage to announce a new mixed reality headset, the Meta Quest 3, as well as new smart glasses made by Ray-Ban that let the wearer livestream videos and interact with an AI-powered voice chatbot. Meta also showed off an array of celebrity-infused AI chatbots that can mimic big-name folks like Snoop Dogg and Kendall Jenner. You'd be forgiven for thinking all this feels a little bit like an episode of Black Mirror.This week on Gadget Lab, we talk with WIRED senior AI writer Khari Johnson about the mixed reality hardware Meta announced this week, its voice-controlled smart glasses, its weird new AI chatbots, and where the company sits in the great AI arms race.Show Notes:Read Khari’s story about Meta’s many AI chatbots. Read Lauren’s story about the upcoming Meta Quest 3 headset and chatbot-enabled Ray-Ban Meta smart glasses.Recommendations:Khari recommends the new movie The Creator. Lauren recommends the ‘90s movie Sliding Doors. Mike also recommends a ‘90s movie, Dazed and Confused.Khari Johnson can be found on social media @kharijohnson. Lauren Goode is @LaurenGoode. Michael Calore is @snackfight. Bling the main hotline at @GadgetLab. The show is produced by Boone Ashworth (@booneashworth). Our theme music is by Solar Keys. Learn about your ad choices: dovetail.prx.org/ad-choices

28 Sep 202336min

Alexa Gets an AI Makeover

Alexa Gets an AI Makeover

Alexa was due for an upgrade, and now it has gotten one. This week, Amazon held its annual media event where it debuted a slate of new hardware, software, and services. The company reserved the spot at center stage for Alexa, the voice assistant powering all of Amazon’s smart home ambitions. Researchers at the company have given Alexa a technological upgrade that enables it to be more competitive in the ChatGPT era. Alexa can now speak more naturally, hold a conversation without as many awkward interactions, and even make its responses sound more emotionally nuanced.This week on Gadget Lab, WIRED senior writer Will Knight joins us to talk about how Alexa is becoming more agile as a conversationalist. Will spoke to Amazon executives about their machine intelligence work, their training models, and how the company is riding the wave of excitement around generative artificial intelligence.Show Notes:Read Will’s report on Alexa’s latest upgrade. Read our roundup of everything Amazon announced at Wednesday’s media event.Recommendations:Will recommends Auto-GPT, a tool that turns ChatGPT an autonomous agent that manages all the boring parts of your life. Mike recommends the book No Meat Required: The Cultural History and Culinary Future of Plant-Based Eating by Alicia Kennedy. Lauren recommends the episode of WIRED’s Have a Nice Future Podcast where journalist Paul Tough talks about college in the US and the future of higher education.Will Knight can be found on Twitter @willknight. Lauren Goode is @LaurenGoode. Michael Calore is @snackfight. Bling the main hotline at @GadgetLab. The show is produced by Boone Ashworth (@booneashworth). Our theme music is by Solar Keys. Learn about your ad choices: dovetail.prx.org/ad-choices

21 Sep 202330min

Your Life, Your iPhone

Your Life, Your iPhone

It's September, which means Apple has announced yet another round of new iPhones. During a typically bombastic media event at the company’s headquarters on Tuesday, Apple showed off regular and Pro versions of the iPhone 15, as well as a couple of new Apple Watch models and a smattering of software enhancements that aim to make moving around with your devices easier. The big news—though something Apple quickly glossed over in its presentation—is that the company has finally eschewed its proprietary Lightning connector in favor of the ubiquitous (and European-Union-mandated) USB-C standard. It's a big change, but one that Apple doesn't exactly seem happy to have been forced into making.This week on Gadget Lab, we dive into all the details about everything Apple announced this week, from the hardware to the software to the services.Show Notes:Dig into everything Apple announced at its September event. Read Adrienne’s story about the new Apple Watch models. Read Julian’s stories about the new iPhones 15 and why it matters that Apple has made the switch to USB-C. Also, check out Lauren’s story about Apple’s new expensive but massive iCloud+ plans. Recommendations:Adrienne recommends Ripton hiker jeans. (Read her story about these technical jorts.) Julian recommends the AnkerWork M650 wireless microphone system. Lauren recommends the latest episode of SmartLess with guest Kara Swisher. Mike recommends shatta, a fermented chile pepper sauce you can find at your local Middle Eastern grocer.Adrienne is on social media as @adriennemso. Julian is @JulianChokkattu. Lauren Goode is @LaurenGoode. Michael Calore is @snackfight. Bling the main hotline at @GadgetLab. The show is produced by Boone Ashworth (@booneashworth). Our theme music is by Solar Keys. Learn about your ad choices: dovetail.prx.org/ad-choices

14 Sep 202338min

We Robloxed So You Don’t Have To

We Robloxed So You Don’t Have To

If you want to see what the future of the internet looks like, peek over your kid’s shoulder while they’re using Roblox. The online platform is filled with free games, experiences, and social hangouts that are designed and built by its users. Curiously, those users are often children; Roblox has 65 million daily active users, and around half of them are under 17.But as Roblox grows, its users are growing up, and the company is making moves to appeal to the changing interests of its aging audience. This week, the company announced it’s bringing animated video chat to its virtual world. The new feature aims to combine the interactions of apps like Zoom and FaceTime with the creative energy of a video game environment. The addition of video chat could also convince older users to buy a premium Roblox subscription or invest in Robux, the platform’s digital currency.This week on Gadget Lab, we dive into the virtual world of Roblox and how the company's offerings are expanding to attract older users, evolve its culture, and create its own version of the metaverse.Show Notes:Read Lauren’s story about Roblox introducing animated video chats to its platform. WIRED’s Will Knight has more about how Roblox is using generative AI. Follow all of WIRED’s coverage of Roblox and other video games.Recommendations:Lauren recommends getting rid of all your extra cables and watching the show Jury Duty on Amazon Prime. Mike recommends Andrew Hickey’s podcast A History of Rock Music in 500 Songs, and ordering bitters and soda at a bar when you don’t want an alcoholic drink.Lauren Goode is @LaurenGoode. Michael Calore is @snackfight. Bling the main hotline at @GadgetLab. The show is produced by Boone Ashworth (@booneashworth). Our theme music is by Solar Keys. Learn about your ad choices: dovetail.prx.org/ad-choices

8 Sep 202337min

I Love You, I Hate You, Don’t Call Me

I Love You, I Hate You, Don’t Call Me

Our smartphones rule our lives. We love them, we hate them. Somewhere deep down inside, we hope they never go away. But, if recent sales data is to be believed, we are also incredibly bored with smartphones—so bored in fact that we’re buying far fewer of them than we used to.This week, we talk about what the future looks like for smartphones. They’ll likely get more foldable, their voice features could grow chattier, and they might even come with a chip to recognize AI-generated nonsense and block it like spam. WIRED senior editor and noted techno-grouser Jason Kehe joins our conversation about the future of the phone and the future of our souls.Note: This episode originally aired March 16, 2023. Read the full transcript.Show NotesRead Lauren’s interviews with five prominent technologists as they predict the phone’s future. The story is part of our WIRED 30 package celebrating our 30th anniversary as a publication.RecommendationsJason recommends Anaximander and the Birth of Science by Carlo Rovelli. Lauren recommends swimming and not podcasting. Mike recommends Why Buddhism Is True by Robert Wright.Jason Kehe can be found on Twitter @jkehe. Lauren Goode is @LaurenGoode. Michael Calore is @snackfight. Bling the main hotline at @GadgetLab. The show is produced by Boone Ashworth (@booneashworth). Our theme music is by Solar Keys. Learn about your ad choices: dovetail.prx.org/ad-choices

31 Aug 202346min

The Case of the Not-Stolen AirPods

The Case of the Not-Stolen AirPods

Most of us who went to school in the United States have been threatened with detention for minor infractions like uttering a curse word or showing up to class five minutes late. But in Illinois, such behavior was landing students in more serious trouble. Since a recent state law prohibited school administrators in Illinois from fining students for infractions, those same administrators turned to the police to handle disciplinary actions. A recent investigation by ProPublica found that local police in Illinois were issuing ticketed citations to thousands of middle school and high school students each year. Kids caught fighting, vaping, skipping class, or even “causing a disturbance”—a sketchily defined catch-all—were facing tickets with fines of up to $500, putting financial strain on the their families, causing them to miss school to attend hearings, and adding to the normal stresses of school life. One case, involving a student who was accused of stealing a pair of AirPods, recently went to a jury trial as the student tried to clear her name.This week on Gadget Lab, ProPublica reporters Jodi S. Cohen and Jennifer Smith Richards join the show to talk about their in-depth reporting of the case of the missing AirPods and how police overreach has affected students in Illinois.Show Notes:Read Jodi and Jennifer’s ProPublica story about the missing AirPods and follow all of their reporting about how police cite students in Illinois.Recommendations:Jennifer recommends putting up a hammock in your backyard. Jodi recommends the Scrub Daddy sponge. Mike recommends the Longreads Top 5 newsletter. Lauren recommends donating to ProPublica.Jodi S. Cohen can be found on Twitter @jodiscohen. Jennifer Smith Richards is @jsmithrichards Lauren Goode is @LaurenGoode. Michael Calore is @snackfight. Bling the main hotline at @GadgetLab. The show is produced by Boone Ashworth (@booneashworth). Our theme music is by Solar Keys. Learn about your ad choices: dovetail.prx.org/ad-choices

24 Aug 202331min

The Cruelest Summer

The Cruelest Summer

Summer isn’t even over here in the Northern Hemisphere, but it’s already been a brutal few months. This year’s summer heat waves have been more frequent, more intense, and longer than any we’ve seen before. We’ve suffered through extreme weather events caused by those heat waves. We’ve seen wildfires that have been made more intense by climate change. We’ve had failures in infrastructure, industry, and the food supply. And of course, these problems are only getting worse. We’re looking at a future where extreme heat is just the new normal.This week, we bring WIRED senior science writer Matt Simon onto the show to talk about where all the heat is coming from and what it’s doing to the environment. We also talk about how quickly the problem of excessive heat is accelerating, and what—if anything—humans can do to slow it down, or at least lessen the damage it causes.Show Notes:Read Matt’s stories about heat waves, the wildfires in Lahaina, Maui, and how the heat is affecting the ocean’s food chains. You can find all of Matt’s WIRED stories in one place. Also, listen to Matt’s appearances on two previous episodes referenced in this week’s talk, when we spoke about microplastics and the Inflation Reduction Act of 2022. Recommendations:Matt recommends the 24 Hours book series that looks at different ancient societies. Lauren recommends the short film “How to Catch a TikTok Thief” from The New Yorker. Mike recommends Connections, the new daily game from The New York Times.Matt Simon can be found on X, the website formerly known as Twitter, @mrMattSimon. Lauren Goode is @LaurenGoode. Michael Calore is @snackfight. Bling the main hotline at @GadgetLab. The show is produced by Boone Ashworth (@booneashworth). Our theme music is by Solar Keys. Learn about your ad choices: dovetail.prx.org/ad-choices

17 Aug 202340min

Nobody’s Driving That Car!

Nobody’s Driving That Car!

Tech companies have been touting self-driving cars as the future of transportation for over a decade now. Companies like Cruise, Waymo, and Zoox all have active programs testing their autonomous vehicles in US cities like San Francisco, Phoenix, and Austin. Their cars have run endless loops around town to train their algorithms, zipping along city streets—and occasionally blocking them. While the tech has clearly gotten better and Waymo and Cruise now have permission to operate fully autonomously in California, the computer-powered taxis have also driven up some controversy with local governments, safety officials, city residents, and drivers.This week on Gadget Lab, WIRED transportation writer Aarian Marshall joins us to talk about how a vote this week in California will affect robotaxi adoption in cities across the country, and what happens when our roadways are inundated with robots.Show Notes:Read Aarian’s story about how ride-hailing service drivers are responding to self-driving taxis. Read all of WIRED’s coverage of autonomous vehicles.Recommendations:Aarian recommends calling company customer support and trying to talk to a human sometimes. Mike recommends listening to comedy albums on streaming services. Lauren recommends her other podcast Have a Nice Future, particularly the episode with the artist Grimes.Aarian Marshall can be found on Twitter @AarianMarshall. Lauren Goode is @LaurenGoode. Michael Calore is @snackfight. Bling the main hotline at @GadgetLab. The show is produced by Boone Ashworth (@booneashworth). Our theme music is by Solar Keys. Learn about your ad choices: dovetail.prx.org/ad-choices

10 Aug 202334min

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