ALLG AMLM16: Does sorafenib plus intensive chemotherapy improve outcome in FLT3-ITD AML?
AML Hub2 Feb 2021

ALLG AMLM16: Does sorafenib plus intensive chemotherapy improve outcome in FLT3-ITD AML?

During the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, the AML Hub spoke to Andrew Wei, The Alfred Hospital, Melbourne, AU, and Natasha S. Anstee, The Alfred Hospital & Monash University, Melbourne, AU. We asked, Does sorafenib plus intensive chemotherapy improve outcome in FLT3-internal tandem duplication (FLT3-ITD) AML?


Wei starts by introducing the clinical study data from AMLM16, a randomized, placebo-controlled trial evaluating sorafenib versus placebo in combination with intensive chemotherapy for previously untreated adult patients with FLT3-ITD AML. In this study, sorafenib did not improve event-free survival when combined with intensive chemotherapy; Wei discusses the possible causes of this result and the subgroups that did better in the sorafenib arm. Anstee then reports the results from the correlative studies evaluating the impact of sorafenib on phospho-FLT3 inhibition and the presence of FLT3-ITD measurable residual disease after chemotherapy.

Hosted on Acast. See acast.com/privacy for more information.

Det här avsnittet är hämtat från ett öppet RSS-flöde och publiceras inte av Podme. Det kan innehålla reklam.

Avsnitt(43)

 FLT3 inhibitors in AML: Current clinical landscape and key insights from trials

FLT3 inhibitors in AML: Current clinical landscape and key insights from trials

The AML Hub was pleased to speak with Mark J. Levis, Johns Hopkins University, Baltimore, US. We asked, What is the current clinical landscape of FLT3 inhibitors in the treatment of AML, and what insi...

1 Juli 4min

Future directions for FLT3 inhibitors in AML treatment

Future directions for FLT3 inhibitors in AML treatment

The AML Hub was pleased to speak with Eytan Stein, Memorial Sloan Kettering Cancer Center, New York, US. We asked, What might the future hold for the evolution of FLT3 inhibitors in the treatment of A...

30 Juni 4min

Key questions in FLT3-mutated AML, and ongoing research to address these

Key questions in FLT3-mutated AML, and ongoing research to address these

The AML Hub was pleased to speak with Charles Craddock, Queen Elizabeth Hospital Birmingham, Birmingham, UK. We asked, What are the key ongoing questions in FLT3-mutated AML, and how are ongoing trial...

26 Juni 5min

Menin inhibitors in AML: Where are we now, and where are we going?

Menin inhibitors in AML: Where are we now, and where are we going?

During a meeting of the AML Hub Steering Committee, held on February 19, 2026, Jorge Cortes chaired a discussion on the topic, Menin inhibitors in AML: Where are we now, and where are we going? The di...

22 Maj 30min

Managing side effects of menin inhibitors in clinical practice

Managing side effects of menin inhibitors in clinical practice

The AML Hub was pleased to speak with Gail Roboz, Weill Cornell Medicine, New York, US. We asked, What side effects are typically observed with menin inhibitor-based regimens, and how do you approach ...

21 Maj 7min

 Mechanisms and rationale for menin inhibitor combination strategies in AML

Mechanisms and rationale for menin inhibitor combination strategies in AML

The AML Hub was pleased to speak with Eunice Wang from Roswell Park Comprehensive Cancer Center, Buffalo, US. We asked, What are the mechanisms and rationale for menin inhibitor combination strategies...

20 Maj 4min

Treatment decisions in AML: Personalizing care with FLT3 inhibitor therapy

Treatment decisions in AML: Personalizing care with FLT3 inhibitor therapy

During a meeting of the AML Hub Steering Committee, held on February 19, 2026, Jorge Sierra chaired a discussion on the topic, Treatment decisions in acute myeloid leukemia (AML): Personalizing care w...

19 Maj 32min

What key insights are emerging from ongoing trials of menin inhibitor combination strategies in AML?

What key insights are emerging from ongoing trials of menin inhibitor combination strategies in AML?

The AML Hub was pleased to speak with Joshua Zeidner, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, US. We asked, What key insights are emerging from ongoing trials...

15 Maj 5min

Populärt inom Utbildning

historiepodden-se
det-skaver
rss-bara-en-till-om-missbruk-medberoende-2
harrisons-dramatiska-historia
nu-blir-det-historia
rss-viktmedicinpodden
allt-du-velat-veta
johannes-hansen-podcast
not-fanny-anymore
rss-traningsklubben
rss-max-tant-med-max-villman
rss-basta-livet
i-vantan-pa-katastrofen
sektledare
sa-in-i-sjalen
rikatillsammans-om-privatekonomi-rikedom-i-livet
sex-pa-riktigt-med-marika-smith
rss-sjalsligt-avkladd
vi-gar-till-historien
rss-okrystat