Alzheimer’s Can Be Prevented & Reversed: Drs. Dean & Ayesha Sherzai On Optimizing Brain Health

Alzheimer’s Can Be Prevented & Reversed: Drs. Dean & Ayesha Sherzai On Optimizing Brain Health

While other major diseases are in decline, deaths from Alzheimer's have increased dramatically in recent decades. In fact, Alzheimer's is currently the 6th (and due to massive under-reporting may be as high as the 3rd ) leading cause of death in the United States. Right now, over 47 million people worldwide currently live with Alzheimer's. By 2050, it's predicted this form of dementia will plague 135.5 million people across the globe. This disease has become so pervasive, chances are you have been directly or indirectly impacted through an afflicted loved one. If so, then you know first hand the devastation it creates. You've seen it's ravaging effects. Perhaps you've even shouldered the immense emotional, financial and social burden it produces — and the hopelessness it provokes. The sad truth is that Alzheimer's is a condition that Western medicine has utterly failed to combat, let alone cure. Simply put, there is no pharmaceutical or surgical treatment to effectively prevent or reverse this savage and cataclysmic condition. But there is hope. Alzheimer's isn't a genetic inevitability. A diagnosis doesn't have to come with a death sentence. In fact, according to this week's guests, 90% of all Alzheimer's cases can be prevented. And for the 10% with a strong genetic risk for cognitive decline, the disease can be delayed for ten to fifteen years. These are not estimates. Nor are they wishful thinking. They are conclusions based on rigorous science performed by neurologists Drs. Dean and Ayesha Sherzai. Co-directors of the Brain Health and Alzheimer's Prevention Program at Loma Linda University Medical Center, Team Sherzai is the dynamic husband and wife duo behind the largest clinical and observational study on Alzheimer's to date as well as the co-authors of The Alzheimer's Solution*, a must-read primer that details their extensive research, chronicles the remarkable results they have experienced working with patients first-hand, and sets forth the first ever comprehensive program to prevent Alzheimer's disease, improve cognitive function, and ultimately optimize long-term brain health. The solution might surprise you. It's not due to a breakthrough in surgical procedures. It's not the result of new pharmaceutical trials. Instead, as far fetched as it may sound, the answer is rooted in fundamental, simple changes in nutrition and lifestyle. Dr. Dean Sherzai, M.D., PhD., completed his medical and neurology residencies at Georgetown University with a subsequent fellowship in neurodegenerative diseases at the National Institutes of Health, followed by a second fellowship in Dementia and Geriatrics at the University of California, San Diego. He also holds two Masters Degrees; in advanced sciences at UCSD and a Masters in public health from Loma Linda University. Finally, he has received a Ph.D. in Healthcare leadership at Loma Linda/Andrews University. Dr. Ayesha Sherzai, M.D., completed her medical residency at Loma Linda University. She subsequently completed a residency in preventive medicine and neurology and thereafter received a fellowship in vascular neurology from Columbia University, and is currently finalizing her PhD in Epidemiology at Loma Linda University. Ayesha also has a culinary degree, giving her a unique understanding of nutrition as a powerful tool for disease prevention. Peace + Plants, Rich

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Rhett & Link On Building A (Mythical) Media Empire, The Price of Public Friendship, & Leaving The Evangelical Church

Rhett & Link On Building A (Mythical) Media Empire, The Price of Public Friendship, & Leaving The Evangelical Church

Rhett McLaughlin and Link Neal are the creators of Good Mythical Morning, one of YouTube's most-watched daily shows with over 19 million subscribers and 8 billion views. This conversation explores their 40-year friendship, spiritual deconstruction from evangelical Christianity, the soul cost of YouTube's algorithm, their self-funded series Wonderhole, and what happens when your best friend is also your business partner. We talk faith, the strain on family life, and the challenge of building an empire without losing your humanity. Along the way, they reveal how their deconstruction ultimately saved their friendship. Rhett and Link have built something incredibly inspiring.  And their story is still unfolding. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up   Today’s Sponsors: On: High-performance shoes & apparel crafted for comfort and style 👉https://www.on.com/richroll                                                                    Squarespace: Use code RichRoll to save 10% off your first order of a website or domain 👉https://www.squarespace.com/RichRoll     AG1: Get a FREE bottle of D3K2, Welcome Kit, and 5 travel packs with your first order 👉https://www.drinkAG1.com/richroll                                             BetterHelp: Get 10% OFF the first month👉 https://www.betterhelp.com/richroll           Rivian: Electric vehicles that keep the world adventurous forever👉https://www.rivian.com Momentous: High-caliber human performance products for sleep, focus, longevity, and more. For listeners of the show, Momentous is offering up to 35% off your first order made through👉 https://www.LiveMomentous.com/richroll Check out all of the amazing discounts from our Sponsors 👉 https://www.richroll.com/sponsors   Find out more about Voicing Change Media at https://www.voicingchange.media  and follow us@voicingchange

8 Sep 2h 11min

Jay Duplass & Michael Strassner On The Art of Creative Rebellion

Jay Duplass & Michael Strassner On The Art of Creative Rebellion

Jay Duplass is an award-winning filmmaker, actor, and co-architect of the mumblecore movement. Michael Strassner is a comedian, actor, and the protagonist of Jay's new film "The Baltimorons." This conversation explores Jay's first solo directing effort in 14 years, Michael's journey from rock bottom to seven years of sobriety, and how they created a transcendent film for less than the cost of an LA permit. We discuss creative authenticity versus Hollywood cynicism, why early sobriety rarely gets screen time, and how serving someone else's story might save your own. In the process, we dissect how cultural mythology is built through storytelling and why flawed humans make better protagonists than superheroes. These two are creating equipment for living. What unfolds is a love letter to persistence. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up   Today’s Sponsors: Seed: Use code RICHROLL25 for 25% OFF your first order 👉https://www.seed.com/RichRoll25                           Squarespace: Use code RichRoll to save 10% off your first order of a website or domain 👉https://www.squarespace.com/RichRoll     Bon Charge Get 15% OFF all my favorite wellness products w/ code RICHROLL 👉https://www.boncharge.com                                                           Roka: Unlock 20% OFF your order with code RICHROLL 👉https://www.ROKA.com/RICHROLL            The Sprouting Company: Get 10% off and a free copy of "The Sprout Book" with code RICHROLL 👉https://www.thesproutingcompany.com/pages/richroll On: High-performance shoes & apparel crafted for comfort and style 👉https://www.on.com/richroll               Check out all of the amazing discounts from our Sponsors 👉 https://www.richroll.com/sponsors   Find out more about Voicing Change Media at https://www.voicingchange.media  and follow us@voicingchange

1 Sep 2h 31min

The Human Brain: Leading Experts On Preventing Cognitive Decline, Understanding Addiction, The Neurochemistry of Spirituality & The Mind-Body Connection

The Human Brain: Leading Experts On Preventing Cognitive Decline, Understanding Addiction, The Neurochemistry of Spirituality & The Mind-Body Connection

Dr. Andrew Huberman, Drs. Ayesha and Dean Sherzai, Dr. Anna Lembke, Dr. Lisa Miller, and Dr. David Spiegel are researchers exploring the mysteries of our most enigmatic organ. This compilation reveals how three pounds of tissue controls everything—from the vascular networks that determine cognitive destiny to the neurochemistry that drives addiction. Why 97% of Alzheimer's cases aren't inevitable, how dopamine traps us, what happens during spiritual experiences, and why hypnosis works. These insights offer understanding of the neural mechanisms that shape every moment of your existence. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up   Today’s Sponsors: On: High-performance shoes & apparel crafted for comfort and style 👉https://www.on.com/richroll                                Roka: Unlock 20% OFF your order with code RICHROLL 👉https://www.ROKA.com/RICHROLL Mint Mobile: Get your 3-month Unlimited plan for just $15/month 👉 https://www.mintmobile.com/richroll AG1: Get a FREE bottle of D3K2, Welcome Kit, and 5 travel packs with your first order 👉https://www.drinkAG1.com/richroll Rivian: Electric vehicles that keep the world adventurous forever👉https://www.rivian.com Check out all of the amazing discounts from our Sponsors 👉 https://www.richroll.com/sponsors Find out more about Voicing Change Media at https://www.voicingchange.media  and follow us@voicingchange

28 Aug 1h 16min

Me, But Better: Olga Khazan On The Science of Personality Change, Challenging Fixed Mindsets, & The Big Five Traits That Shape Your Life

Me, But Better: Olga Khazan On The Science of Personality Change, Challenging Fixed Mindsets, & The Big Five Traits That Shape Your Life

Olga Khazan is a staff writer for The Atlantic and author of "Me, But Better." This conversation explores personality mutability and Olga's experiment to transform from anxious introvert to someone freed from her own patterns. We discuss the Big Five traits, her Miami breakdown that sparked everything, and why anxiety isn't actually your superpower. Along the way, we examine the paradox of self-acceptance. This exchange is about agency, transformation, and why we amplify our suffering. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up   Today’s Sponsors: Lincoln Financial: Check out the NEW 4-part series "The Action Plan"👉https://www.lincolnfinancial.com/richroll                                                    On: High-performance shoes & apparel crafted for comfort and style 👉https://www.on.com/richroll              AG1: Get a FREE bottle of D3K2, Welcome Kit, and 5 travel packs with your first order 👉https://www.drinkAG1.com/richroll Birch Living:  Sustainable mattresses with a 100-night risk-free trial. For 20% off site-wide visit BirchLiving.com/richroll. BetterHelp: Get 10% OFF the first month 👉 https://www.betterhelp.com/richroll WHOOP: The all-new WHOOP 5.0 is here! Get your first month FREE👉https://www.join.whoop.com/Roll   Check out all of the amazing discounts from our Sponsors 👉 https://www.richroll.com/sponsors   Find out more about Voicing Change Media at https://www.voicingchange.media  and follow us@voicingchange

25 Aug 2h 12min

Addiction, Celebrity, Public Shaming & Truth: The Performance Art of James Frey, Celebrated Writer of Ill-Repute

Addiction, Celebrity, Public Shaming & Truth: The Performance Art of James Frey, Celebrated Writer of Ill-Repute

James Frey is the author of "A Million Little Pieces," a book that spoke to the deepest, darkest parts of countless readers in early recovery. This conversation explores his journey to become literature's bad boy, his heroes like Baudelaire and Henry Miller, and his philosophy of "prowling with the panther." We discuss the intersection of creativity and the Tao, where inspiration comes from, and his unique approach to capturing vitality on the page. Along the way, James recounts a few things he's never shared publicly. This is a manifesto on the importance of muscular books written by authors with courage. Buckle up. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up   Today’s Sponsors: Go Brewing: Use the code Rich Roll for 15% OFF 👉https://www.gobrewing.com On: High-performance shoes & apparel crafted for comfort and style 👉https://www.on.com/richroll              Momentous: Save 35% OFF your first subscription order 👉https://www.livemomentous.com/richroll                              Roka: Unlock 20% OFF your order with code RICHROLL 👉https://www.ROKA.com/RICHROLL            BetterHelp: Get 10% OFF the first month👉 https://www.betterhelp.com/richroll Rivian: Electric vehicles that keep the world adventurous forever👉https://www.rivian.com Check out all of the amazing discounts from our Sponsors 👉 https://www.richroll.com/sponsors   Find out more about Voicing Change Media at https://www.voicingchange.media  and follow us@voicingchange

18 Aug 2h 34min

ROLL ON: The State of Podcasting In 2025

ROLL ON: The State of Podcasting In 2025

Roll On resurfaces from the chrysalis! Adam Skolnick and I unpack 90 days post-surgery, why the caterpillar needs a tortoise mind to become a butterfly, and the death of authentic podcasting. On tap: The state of Podcastistan, why I'm breaking up with viral culture, and the unexpected joy of moving at glacier pace. We explore Phil Stutz's three truths, Alaska's last frontier vibes, and why Deadwood still hits different. Plus: Movies are officially back, friends of the pod crushing impossible distances—because regular suffering is passé—and why community beats audience every damn time. Enjoy! Show notes + MOREWatch on YouTubeNewsletter Sign-Up   Today’s Sponsors: LMNT: Get a free LMNT Sample Pack with any purchase 👉 https://www.drinklmnt.com/richroll                                                                                  Seed: Use code RICHROLL25 for 25% OFF your first order 👉https://www.seed.com/RichRoll25 Pique: Get up to 20% OFF plus a FREE rechargeable frother and glass beaker with your first subscription 👉https://www.piquelife.com/richroll Momentous: Save 35% OFF your first subscription order 👉https://www.livemomentous.com/richroll   Calm: Get 40% off a Calm Premium subscription 👉 https://www.calm.com/richroll Prolon: Get 15% OFF plus a FREE bonus gift 👉 https://www.prolonlife.com/richroll Mint Mobile: Get your 3-month Unlimited plan for just $15/month 👉 https://www.mintmobile.com/richroll Check out all of the amazing discounts from our Sponsors 👉 https://www.richroll.com/sponsors   Find out more about Voicing Change Media at https://www.voicingchange.media  and follow us@voicingchange

14 Aug 1h 35min

Inside Nutrition Misinformation: Nutrition Scientist Jessica Knurick Exposes What's Really Happening to Public Health in America

Inside Nutrition Misinformation: Nutrition Scientist Jessica Knurick Exposes What's Really Happening to Public Health in America

This conversation explores the war on science, the misdirection of the MAHA movement, and what's happening to public health while everyone argues about food dyes. We discuss how a $1.1 trillion healthcare cut happened under the radar, why "seed oils" didn't exist until TikTok invented them, and Jessica's systemic solutions for actually making America healthy. Additionally, she explains how health misinformation has become a profitable fear machine. Jessica brings compassionate clarity to the current health policy landscape. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up   Today’s Sponsors:  Go Brewing: Use the code Rich Roll for 15% OFF 👉https://www.gobrewing.com Squarespace: Use code RichRoll to save 10% off your first order of a website or domain 👉https://www.squarespace.com/RichRoll     Lincoln Financial: Check out the NEW 4-part series "The Action Plan"👉https://www.lincolnfinancial.com/richroll                                                             AG1: Get a FREE bottle of D3K2, Welcome Kit, and 5 travel packs with your first order 👉https://www.drinkAG1.com/richroll                                             Roka: Unlock 20% OFF your order with code RICHROLL 👉https://www.ROKA.com/RICHROLL            On: High-performance shoes & apparel crafted for comfort and style 👉https://www.on.com/richroll              WHOOP: The all-new WHOOP 5.0 is here! Get your first month FREE👉https://www.join.whoop.com/Roll                        Check out all of the amazing discounts from our Sponsors 👉 https://www.richroll.com/sponsors   Find out more about Voicing Change Media at https://www.voicingchange.media  and follow us@voicingchange

11 Aug 2h

Inner Excellence: Jim Murphy On Overcoming Mental Blocks, Mastering The Ego, Success Through Selflessness & The Pillars of Extraordinary Performance

Inner Excellence: Jim Murphy On Overcoming Mental Blocks, Mastering The Ego, Success Through Selflessness & The Pillars of Extraordinary Performance

Jim Murphy is the author of "Inner Excellence," a book compelling enough that NFL players read it during playoff games. This conversation explores Jim's counterintuitive thesis that selflessness, not ego, is the foundation of fearless performance. We discuss his journey from mental breakdown to spiritual awakening, his five years of solitude in the desert, and why self-centeredness is our greatest obstacle to both peak performance and fulfillment. Along the way, Jim reveals my own attachment to outcomes and the transactional relationship I have with love. Jim's wisdom is hard-won. This conversation is powerful. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up   Today’s Sponsors: Bon Charge Get 15% OFF all my favorite wellness products w/ code RICHROLL 👉https://www.boncharge.com                                         Squarespace: Use code RichRoll to save 10% off your first order of a website or domain 👉https://www.squarespace.com/RichRoll     BetterHelp: Get 10% OFF the first month👉 https://www.betterhelp.com/richroll           On: High-performance shoes & apparel crafted for comfort and style 👉https://www.on.com/richroll              Seed: Use code RICHROLL25 for 25% OFF your first order👉https://www.seed.com/RichRoll Rivian: Electric vehicles that keep the world adventurous forever👉https://www.rivian.com   Check out all of the amazing discounts from our Sponsors 👉 https://www.richroll.com/sponsors   Find out more about Voicing Change Media at https://www.voicingchange.media  and follow us@voicingchange

4 Aug 2h 7min

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