Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Aging

Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Aging

Aging is inevitable. Everybody grows old. Everyone dies. We accept these statements as fact. But what if they're just stories based on history and our current understanding of biology? What if everything we think we know about aging is about to change? Across the globe, scientists are working on treatments and therapies that are designed to extend healthy human lifespans well beyond what we know today. At the bleeding edge of such breakthroughs you will find David Sinclair, PhD, one of the world’s leading scientific authorities on longevity, aging and how to slow its effects. Returning for his second appearance on the podcast, David is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995 and worked as a postdoctoral researcher at M.I.T. where, among other things, he co-discovered the cause of aging for yeast. The co-founder of several biotechnology companies, David is also co-founder and co-chief editor of the journal Aging. His work has been featured in a variety of books, documentaries, and media, including 60 Minutes, Nightline and NOVA. He is an inventor on 35 patents, has been lauded as one of the Top 100 Australian Innovators, and made TIME magazine’s list of the 100 most influential people in the world. In addition, David is the author of Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't Have To -- a New York Times bestseller that proposes a radical new theory of aging. As he writes: “Aging is a disease, and that disease is treatable.” Last year I convened my first conversation with David (RRP #436), a scintillating and science-heavy primer on all things human lifespan, aging and longevity. It was a runaway hit with the listeners -- and left me wanting to know more. So today we pick up where we last left off, diving deeper into the physiological mechanisms that contribute to biological degeneration. And we go further into the current state of research to better understand what contributes to aging and what can be done to counteract it. Call him a dreamer, but David believes living to 200+ is a plausible reality. If you could double your lifespan, how would this impact how you choose to live? What would it mean for the future of humanity? And for the ecological stability of the planet? The implications are profound. Equal parts philosophic and scientific, this conversation will forever change the way you think about why you age and what you can do about it. And it will leave you armed simple lifestyle practices you can deploy -- intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat -- that will help you live younger and healthier for longer. Brilliant and lovely, it’s an honor to once again share this man's wisdom with you today. So break out that pen and paper, because you're going to want to take notes on this one. The visually inclined can watch it all go down on YouTube. And as always, the audio version streams wild and free on Apple Podcasts and Spotify. I sincerely hope you enjoy the episode. Peace + Plants, Rich

Avsnitt(958)

The Man Who (Literally) Owns Nothing: Radical Minimalist Robin Greenfield On Barefoot Walking 1,600 Miles, Living In Harmony With Earth, & Finding Freedom Through Simplicity

The Man Who (Literally) Owns Nothing: Radical Minimalist Robin Greenfield On Barefoot Walking 1,600 Miles, Living In Harmony With Earth, & Finding Freedom Through Simplicity

Robin Greenfield is a transcendental environmental activist who has taken the concept of simplicity to its existential extreme. This conversation explores how Robin's radical approach to consumption challenges our assumptions about possession, examining his 1,600-mile journey down the Pacific coast, his current experiment living in Griffith Park with absolutely nothing, the nature of contentment, our interdependence with Earth, and the liberation found in surrendering attachment. At one point, he fashions a toothbrush from a California bay branch right before our eyes. Robin is minimalism personified. This conversation will recalibrate your material perspective. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: 1.  On: High-performance shoes & apparel crafted for comfort and style 👉on.com/richroll 2.  Momentous: 20% OFF all of my favorite products  👉livemomentous.com/richroll 3.  BetterHelp: Get 10% OFF the first month👉BetterHelp.com/richroll. 4.  LMNT: Get a FREE LMNT sample pack for just $5 shipping 👉 drinkLMNT.com/RICHROLL. 5. IQBAR: Get 20% OFF all IQBAR products plus FREE shipping. Just text RICHROLL to sixty-four thousand. Message and data rates may apply. Check out all of the amazing discounts from our Sponsors 👉 richroll.com/sponsors   Find out more about Voicing Change Media at voicingchange.media and follow us @voicingchange

13 Mars 2h 31min

Annaka Harris On Why Consciousness Just Might Be Fundamental To Reality

Annaka Harris On Why Consciousness Just Might Be Fundamental To Reality

Annaka Harris is a New York Times bestselling author and creator of the groundbreaking audio documentary series “Lights On.”   This conversation explores the profound question of whether consciousness is fundamental to the universe rather than merely an emergent property of complex matter. We discuss the ineffable nature of felt experience, the illusion of self, and how our perceptual limitations restrict our understanding of the world around us.   Also, I share a very personal and meaningful experience that changed how I think about the nature of reality.   Annaka is an insightful guide whose perspectives may shift your thinking about the substrate of existence. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: iFit: Use the code RICHROLL to get 10% off any purchase of $999+ 👉 nordictrack.com/RICHROLL Squarespace: Use the offer code RichRoll to save 10% off your first purchase  👉Squarespace.com/RichRoll AG1: Get a FREE bottle of Vitamin D3+K2 AND 5 free AG1 Travel Packs 👉drinkAG1.com/richroll Calm: Get 40% off a Calm Premium subscription 👉 calm.com/richroll On Running: High-performance shoes & apparel crafted for comfort and style 👉on.com/richroll OneSkin: Get 15% off with the code RICHROLL👉 oneskin.co Check out all of the amazing discounts from our Sponsors 👉 richroll.com/sponsors   Find out more about Voicing Change Media at voicingchange.media and follow us @voicingchange

10 Mars 1h 38min

Emotional Fitness: Dr. Ethan Kross On Dealing With Difficult Feelings, Controlling Your Inner Voice & The Science of Emotional Regulation

Emotional Fitness: Dr. Ethan Kross On Dealing With Difficult Feelings, Controlling Your Inner Voice & The Science of Emotional Regulation

Dr. Ethan Kross is a renowned psychologist, bestselling author, and expert on controlling the conscious mind.   This conversation explores his innovative approach to mental fitness and how our emotions function as an operating system. We examine why difficult emotions serve a purpose, how our inner dialogue shapes our reality, and why we have more control over our responses than we realize.   Along the way, he helps me analyze my own patterns of thought spirals and disaster-casting.   Ethan’s work offers a pattern interrupt for those caught in mental turbulence and a roadmap to greater agency. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up  Today’s Sponsors:    Momentous: 20% OFF all of my favorite products👉livemomentous.com/richroll Bon Charge: Get 15% OFF all my favorite wellness products w/ code RICHROLL👉 boncharge.com Squarespace: Use the code RichRoll to save 10% off your first purchase of a website or domain 👉Squarespace.com/RichRoll Check out all of the amazing discounts from our Sponsors 👉 richroll.com/sponsors   Find out more about Voicing Change Media at voicingchange.media and follow us @voicingchange

3 Mars 2h 18min

SOFI TUKKER On Unlikely EDM Superstardom, The Hard Business of Music, And The Athletic Art of Performance

SOFI TUKKER On Unlikely EDM Superstardom, The Hard Business of Music, And The Athletic Art of Performance

Sophie Hawley-Weld and Tucker Halpern, together known as SOFI TUKKER, defy every convention of electronic dance music.   This conversation explores their unlikely origin story—from D1 basketball captain and aspiring diplomat to electronic music revolutionaries who’ve achieved stratospheric success by approaching their craft with athletic discipline and meditative mindfulness. Through an alchemy of Portuguese poetry and pulsing beats, they’ve amassed over 3 billion streams, scored multiple Grammy nominations, and landed high-profile Apple campaigns while sustaining well-being amidst non-stop touring.   These two transformed my understanding of what electronic artists can be.   SOFI TUKKER is a revelation—and a testament to the power of authentic self-expression. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: Momentous: 20% OFF all of my favorite products👉livemomentous.com/richroll BetterHelp: Use the code RICHROLL to get 10% off your first month👉BetterHelp.com/richroll Calm: Get get 40% off a Calm Premium subscription👉calm.com/richroll RocketMoney: Cancel your unwanted subscriptions and reach your financial goals faster with Rocket Money 👉 RocketMoney.com/RICHROLL                                                 Check out all of the amazing discounts from our Sponsors 👉 richroll.com/sponsors   Find out more about Voicing Change Media at voicingchange.media and follow us @voicingchange

27 Feb 2h 1min

The Mindful Body: Harvard’s Dr. Ellen Langer On The Power Of Mindfulness, How Thoughts Can Control Health, & Using Perspective To Lower Stress

The Mindful Body: Harvard’s Dr. Ellen Langer On The Power Of Mindfulness, How Thoughts Can Control Health, & Using Perspective To Lower Stress

Dr. Ellen Langer is Harvard’s first tenured female psychology professor, a pioneering researcher on the mind-body connection, and author of “The Mindful Body.”     This conversation explores the radical impact of certainty on well-being and Ellen’s perspective that redefines traditional notions of mindfulness through the simple act of noticing new things.   In her return, we discuss why uncertainty brings freedom, how thoughts influence health outcomes, the kaleidoscopic nature of consciousness, and why everything we think we know deserves to be questioned.   Ellen is brilliant, irreverent, and wise. Her insights may transform how you think about thinking. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: Roka: Unlock 20% OFF your order with code RICHROLL 👉ROKA.com/RICHROLL    AG1: Get a FREE bottle of Vitamin D3+K2 AND 5 free AG1 Travel Packs 👉drinkAG1.com/richroll Go Brewing: Use the code Rich Roll for 15% OFF 👉gobrewing.com Check out all of the amazing discounts from our Sponsors 👉 richroll.com/sponsors Dr. Ellen Langer will be hosting a private, intimate Couples Retreat in Puerto Vallarta Mexico March 9-14, 2026.  For information please email Randy Lennon at randy@lennon.media.  Find out more about Voicing Change Media at voicingchange.media and follow us @voicingchange

24 Feb 2h 23min

Happiness Is A Direction: Harvard Professor Arthur Brooks On Navigating Crisis, Building Better Relationships, Finding Meaning, & What Actually Makes Us Happy

Happiness Is A Direction: Harvard Professor Arthur Brooks On Navigating Crisis, Building Better Relationships, Finding Meaning, & What Actually Makes Us Happy

Arthur Brooks is a Harvard professor, behavioral scientist, and the world’s leading researcher on happiness.   This conversation explores the ineffable nature of happiness and meaning, explores why success addiction plagues high achievers, and discusses how science can open a portal to deeper truths. We investigate the dualistic tension between striving and surrender, as Arthur reveals how our fixation on striving often obscures the true source of happiness.   Through a captivating shift in perspective, he sheds light on a new understanding of love, purpose, and fulfillment.   The intersection of science and happiness begins here. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: Seed: Use code RICHROLL25 for 25% OFF your first order 👉seed.com/RichRoll       On Running: High-performance shoes & apparel crafted for comfort and style 👉on.com/richroll Birch: For 27% off ALL mattresses 👉BirchLiving.com/richroll Pique: Get up to 20% OFF plus a FREE rechargeable frother and glass beaker with your first purchase 👉piquelife.com/richroll Calm: Get 40% off a Calm Premium subscription 👉 calm.com/richroll Prolon: Get 15% OFF plus a FREE bonus gift 👉 prolonlife.com/richroll   Check out all of the amazing discounts from our Sponsors 👉 richroll.com/sponsors   Find out more about Voicing Change Media at voicingchange.media and follow us @voicingchange

17 Feb 2h 16min

Rivian Founder RJ Scaringe Is Building The Future: Leadership, Mindset, Innovation, & His Mission To Decarbonize Transportation

Rivian Founder RJ Scaringe Is Building The Future: Leadership, Mindset, Innovation, & His Mission To Decarbonize Transportation

RJ Scaringe is the visionary founder of Rivian, who turned his childhood obsession with engines into one of automotive history’s most audacious ventures.   This conversation explores the intractable challenges of starting a car company from scratch, balancing “extreme optimism” with “robust realism,” and why this moment represents a once-in-a-planet opportunity to reinvent transportation.    RJ shares intimate details of Rivian’s journey toward a carbon-neutral future, from nearly running out of payroll to leading a publicly traded company.   This is a masterclass in playing the long game. Enjoy!   Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: Momentous: 20% OFF all of my favorite products  👉livemomentous.com/richroll On: High-performance shoes & apparel crafted for comfort and style 👉on.com/richroll Roka: Unlock 20% OFF your order with code RICHROLL  👉ROKA.com/RICHROLL One Skin: Get 15% OFF with the code RICHROLL 👉 oneskin.co                             Check out all of the amazing discounts from our Sponsors 👉 richroll.com/sponsors   Find out more about Voicing Change Media at voicingchange.media and follow us @voicingchange

13 Feb 1h 23min

Fasting For Longevity: Valter Longo, PhD Shares Cutting-Edge Fasting Science & Optimal Nutrition Protocols For Lifespan Extension & Disease Prevention

Fasting For Longevity: Valter Longo, PhD Shares Cutting-Edge Fasting Science & Optimal Nutrition Protocols For Lifespan Extension & Disease Prevention

Dr. Valter Longo is a pioneering longevity researcher, Director of the USC Longevity Institute, and one of TIME’s 50 most influential people in healthcare. This conversation explores his groundbreaking Fasting Mimicking Diet and its profound implications for aging, disease treatment, and longevity. From cancer therapy to diabetes reversal, Valter reveals how therapeutic fasting could transform modern medicine. Along the way, Valter challenges my long-held assumptions about protein intake and sleep. His research offers hope for extending human healthspan, and this conversation is illuminating at every turn. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors:  Seed: Use code RICHROLL25 to get 25% off your first month 👉https://bit.ly/seedxrrp2025 Squarespace: Use code RichRoll to save 10% off 👉https://bit.ly/squarespace2025 Go Brewing: Use the code Rich Roll for 15% OFF  👉gobrewing.com  iFit: Use the code RICHROLL to get 10% off any purchase of $999+ 👉 nordictrack.com/RICHROLL LMNT: Get a FREE LMNT sample pack for just $5 shipping 👉 drinkLMNT.com/RICHROLL BetterHelp: Use the code RICHROLL to get 10% off your first month 👉BetterHelp.com/richroll Check out all of the amazing discounts from our Sponsors 👉 richroll.com/sponsors Find out more about Voicing Change Media at voicingchange.media and follow us @voicingchange

10 Feb 1h 59min

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