Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis

Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis

This week, I am joined by microbiologist Dr. Sarkis Mazmanian, the Luis B. and Nelly Soux Professor at Caltech, to discuss the microbiome's connection to human health—especially the gut-brain axis. Dr. Mazmanian discusses his research evolution from infectious diseases to the microbiome’s role in neurodevelopment and neurodegeneration, as well as how gut microbes influence neurological health, behavior, and conditions like Parkinson's, autism, and depression. He highlights the human gut microbe symbiosis, early-life microbial exposure's influence, and the adult microbiome's malleability. We explore microbiome-based therapeutics' potential, challenges in translating animal models to humans, personalized medicine's future, the microbiome's impact on drug efficacy, gut bacteria's influence on behaviors and cravings, and the importance of a healthy gut diet. Please enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: AG1: Get a FREE 1-year supply of Vitamin D3+K2 AND 5 free AG1 Travel Packs 👉drinkAG1.com/richroll InsideTracker: Use code RICHROLL at checkout and enjoy 10% OFF the InsideTracker Subscription and any plan 👉insidetracker.com/richroll On: 10% OFF your first order of high-performance shoes and apparel w/ code RICHROLL10👉on.com/richroll Roka: Unlock 20% OFF sunglasses & eyewear with code RICHROLL 👉roka.com/richroll Go Brewing: Use the code Rich Roll for 15% OFF my favorite non-alcoholic brews 👉gobrewing.com Squarespace: Use the offer code RichRoll to save 10% off your first purchase of a website or domain 👉Squarespace.com/RichRoll

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Make Change That Lasts: Break Free From Bad Habits & Transform Your Life For Good With Dr. Rangan Chatterjee

Make Change That Lasts: Break Free From Bad Habits & Transform Your Life For Good With Dr. Rangan Chatterjee

Dr. Rangan Chatterjee is a renowned physician, one of Britain’s most influential medical voices, and author of the new book, “Make Change That Lasts.” This conversation explores the intersection of n...

23 Dec 20242h 14min

Entrepreneurship Is A Mindset: Shopify President Harley Finkelstein On Why Failure Is The Path To Success

Entrepreneurship Is A Mindset: Shopify President Harley Finkelstein On Why Failure Is The Path To Success

Harley Finkelstein is Shopify’s President and an entrepreneur who started his first company at 13. This conversation explores the intersection of commerce and personal growth through Harley’s iconocl...

16 Dec 20242h 9min

An Uncomfortable Conversation With Josh Szeps: Media Silos, Disagreeing With Grace, Protecting Liberal Democracy, & What The 2024 Election Was Really About

An Uncomfortable Conversation With Josh Szeps: Media Silos, Disagreeing With Grace, Protecting Liberal Democracy, & What The 2024 Election Was Really About

Josh Szeps is a renowned broadcaster, host of Uncomfortable Conversations, and a former voice of Australia’s public radio who brings discernment to our most difficult dialogues. This conversation exp...

12 Dec 20242h 19min

The Neuroscience Of Memory: Deja Vu, Photographic Memory, Improving Cognition & Why We Remember With Charan Ranganath, PhD

The Neuroscience Of Memory: Deja Vu, Photographic Memory, Improving Cognition & Why We Remember With Charan Ranganath, PhD

Dr. Charan Ranganath is a prominent neuroscientist, a professor at UC Davis, and the author of the influential book “Why We Remember.”  This conversation explores the profound intersection of neurosc...

9 Dec 20242h 30min

The Mad Scientist Of Ultra-Endurance: David Roche’s Hyper-Precise Experiment That Broke The Leadville 100 Record

The Mad Scientist Of Ultra-Endurance: David Roche’s Hyper-Precise Experiment That Broke The Leadville 100 Record

David Roche is an iconoclastic ultrarunner who broke one of running’s most hallowed records at the Leadville 100—in his first attempt at the distance. This conversation explores his audacious and cou...

2 Dec 20242h 32min

The Norwegian Train Gets Back On Track: Kristian Blummenfelt Unpacks Kona, The Olympics, Training, & Lessons On Resilience After Failure

The Norwegian Train Gets Back On Track: Kristian Blummenfelt Unpacks Kona, The Olympics, Training, & Lessons On Resilience After Failure

Kristian Blummenfelt is an Olympic champion, sub-7-hour Ironman record holder, and master practitioner of the Norwegian Method—a revolutionary, science-driven approach to endurance training. This con...

28 Nov 20241h 12min

Root Cause Health: Robin Berzin, MD On Functional Medicine, Longevity For Women, GLP-1s, Hormone Therapy, & Utilizing Lifestyle For Long-Term Well-Being

Root Cause Health: Robin Berzin, MD On Functional Medicine, Longevity For Women, GLP-1s, Hormone Therapy, & Utilizing Lifestyle For Long-Term Well-Being

Dr. Robin Berzin is the Founder and CEO of Parsley Health, and a paradigm-shifting force in primary care who’s made functional medicine accessible to millions. This conversation explores the interpla...

25 Nov 20242h 12min

Reignite Your Relationship: Esther Perel On Desire, Intimacy, Sex, & Long-Term Love

Reignite Your Relationship: Esther Perel On Desire, Intimacy, Sex, & Long-Term Love

Esther Perel is a renowned psychotherapist, bestselling author, and host of the groundbreaking podcast “Where Should We Begin?” This conversation explores the vicissitudes of modern love and Esther’s...

18 Nov 20242h 2min

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