Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis

Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis

This week, I am joined by microbiologist Dr. Sarkis Mazmanian, the Luis B. and Nelly Soux Professor at Caltech, to discuss the microbiome's connection to human health—especially the gut-brain axis. Dr. Mazmanian discusses his research evolution from infectious diseases to the microbiome’s role in neurodevelopment and neurodegeneration, as well as how gut microbes influence neurological health, behavior, and conditions like Parkinson's, autism, and depression. He highlights the human gut microbe symbiosis, early-life microbial exposure's influence, and the adult microbiome's malleability. We explore microbiome-based therapeutics' potential, challenges in translating animal models to humans, personalized medicine's future, the microbiome's impact on drug efficacy, gut bacteria's influence on behaviors and cravings, and the importance of a healthy gut diet. Please enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: AG1: Get a FREE 1-year supply of Vitamin D3+K2 AND 5 free AG1 Travel Packs 👉drinkAG1.com/richroll InsideTracker: Use code RICHROLL at checkout and enjoy 10% OFF the InsideTracker Subscription and any plan 👉insidetracker.com/richroll On: 10% OFF your first order of high-performance shoes and apparel w/ code RICHROLL10👉on.com/richroll Roka: Unlock 20% OFF sunglasses & eyewear with code RICHROLL 👉roka.com/richroll Go Brewing: Use the code Rich Roll for 15% OFF my favorite non-alcoholic brews 👉gobrewing.com Squarespace: Use the offer code RichRoll to save 10% off your first purchase of a website or domain 👉Squarespace.com/RichRoll

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Jay Duplass & Michael Strassner On The Art of Creative Rebellion

Jay Duplass & Michael Strassner On The Art of Creative Rebellion

Jay Duplass is an award-winning filmmaker, actor, and co-architect of the mumblecore movement. Michael Strassner is a comedian, actor, and the protagonist of Jay's new film "The Baltimorons." This co...

1 Sep 20252h 31min

The Human Brain: Leading Experts On Preventing Cognitive Decline, Understanding Addiction, The Neurochemistry of Spirituality & The Mind-Body Connection

The Human Brain: Leading Experts On Preventing Cognitive Decline, Understanding Addiction, The Neurochemistry of Spirituality & The Mind-Body Connection

Dr. Andrew Huberman, Drs. Ayesha and Dean Sherzai, Dr. Anna Lembke, Dr. Lisa Miller, and Dr. David Spiegel are researchers exploring the mysteries of our most enigmatic organ. This compilation reveal...

28 Aug 20251h 16min

Me, But Better: Olga Khazan On The Science of Personality Change, Challenging Fixed Mindsets, & The Big Five Traits That Shape Your Life

Me, But Better: Olga Khazan On The Science of Personality Change, Challenging Fixed Mindsets, & The Big Five Traits That Shape Your Life

Olga Khazan is a staff writer for The Atlantic and author of "Me, But Better." This conversation explores personality mutability and Olga's experiment to transform from anxious introvert to someone f...

25 Aug 20252h 12min

Addiction, Celebrity, Public Shaming & Truth: The Performance Art of James Frey, Celebrated Writer of Ill-Repute

Addiction, Celebrity, Public Shaming & Truth: The Performance Art of James Frey, Celebrated Writer of Ill-Repute

James Frey is the author of "A Million Little Pieces," a book that spoke to the deepest, darkest parts of countless readers in early recovery. This conversation explores his journey to become literat...

18 Aug 20252h 34min

ROLL ON: The State of Podcasting In 2025

ROLL ON: The State of Podcasting In 2025

Roll On resurfaces from the chrysalis! Adam Skolnick and I unpack 90 days post-surgery, why the caterpillar needs a tortoise mind to become a butterfly, and the death of authentic podcasting. On tap...

14 Aug 20251h 35min

Inside Nutrition Misinformation: Nutrition Scientist Jessica Knurick Exposes What's Really Happening to Public Health in America

Inside Nutrition Misinformation: Nutrition Scientist Jessica Knurick Exposes What's Really Happening to Public Health in America

This conversation explores the war on science, the misdirection of the MAHA movement, and what's happening to public health while everyone argues about food dyes. We discuss how a $1.1 trillion health...

11 Aug 20252h

Inner Excellence: Jim Murphy On Overcoming Mental Blocks, Mastering The Ego, Success Through Selflessness & The Pillars of Extraordinary Performance

Inner Excellence: Jim Murphy On Overcoming Mental Blocks, Mastering The Ego, Success Through Selflessness & The Pillars of Extraordinary Performance

Jim Murphy is the author of "Inner Excellence," a book compelling enough that NFL players read it during playoff games. This conversation explores Jim's counterintuitive thesis that selflessness, not...

4 Aug 20252h 7min

Dr. Mindy Pelz On Women's Hormonal Health, Cyclical Fasting, Health As A Verb, Reclaiming Your Body's Intelligence & Transforming Menopause Into Empowerment

Dr. Mindy Pelz On Women's Hormonal Health, Cyclical Fasting, Health As A Verb, Reclaiming Your Body's Intelligence & Transforming Menopause Into Empowerment

Dr. Mindy Pelz is a functional medicine expert, bestselling author of "Fast Like a Girl," and a specialist in women's hormonal health. This conversation explores why modern life creates an evolutiona...

31 Juli 20252h 10min

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