The Chromodiversity™ Podcast12 Juli 2022

XXY HEART, BONE, IMMUNITY, FERTILITY & SEXUAL FUNCTION

🔴 Part V - “Klinefelter Syndrome: Integrating Genetics, Neuropsychology, and Endocrinology.”

Episodes 5 to 11 are dedicated to the most extensive review of research on XXY to date. Episode 9 (Part V) shows that XXY is associated to a more severe range of physical issues than previously thought, many of which can be avoided or reduced through preventive measures. For instance lifelong risk of Venous Thrombosis (VTE) is multiplied by 6 overall & by 12 in individuals under 30, increasing morbidity & mortality at a young age: low dose aspirin or statins are likely to be helpful. Early osteoporosis is far more common: a combination of vitamin B, calcium supplementation and testosterone may keep these issues at bay.

While used to be thought most XXY males could not have biological children, this is no longer the case. mTESE technology results in up to 50% success rates in retrieving viable sperm. KS can also affect sexual function: while testosterone therapy may help, metabolic & psychological issues also need to be addressed.

Authors: Claus H. Gravholt, Simon Chang, Mikkel Wallentin, Jens Fedder, Philip Moore and Anne Skakkebæk.

Publication: Endocrine Reviews, 2018. doi: 10.1210/er.2017-00212. Original Article (pdf download) available on chromodiversity.com.

Keywords: #XXY, #CardiovascularDisease #Vasculature #VenousThrombosis #CerebrovascularDisease #Osteoporosis #AutoimmuneDisease #AddisonDisease #Diabetes #MultipleSclerosis, #Hypothyroidism #RheumatoidArthritis, #SjogrenSyndrome, #LupusErythematosus #Fertility #mTESE #cryopreservation #SexualDysfunction

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