Influence of Histone Variants on Chromatin Structure and Metabolism (Markus Buschbeck)

Influence of Histone Variants on Chromatin Structure and Metabolism (Markus Buschbeck)

In this episode of the Epigenetics Podcast, we sat down with Marcus Buschbeck, Group Leader at the Josep Carreras Leukaemia Research Institute in Barcelona, to talk about his work on the histone variant macroH2A, its role in metabolism and how it contributes to the regulation of chromatin structure.

Histone variants equip chromatin with unique properties and show a specific genomic distribution. The histone variant macroH2A is unique in having a tripartite structure consisting of a N-terminal histone-fold, an intrinsically unstructured linker domain and a C-terminal macro domain. Recent discoveries show that macroH2A proteins have a major role in the nuclear organization which has the potential to explain how these proteins can act as tumor suppressors, promoters of differentiation and barriers to somatic cell reprogramming.

We discuss these topics, the mission of the Josep Carreras Leukaemia Research Institute, and much more in this episode.

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The Human Cell Atlas (Sarah Teichmann)

The Human Cell Atlas (Sarah Teichmann)

In this episode of the Epigenetics Podcast, we talked with Sarah Teichmann from the University of Cambridge about the Human Cell Atlas. In the Interview we explore Sarah Teichmann's impressive career ...

10 Juli 202546min

The Discovery of Genomic Imprinting (Azim Surani)

The Discovery of Genomic Imprinting (Azim Surani)

In this episode, Professor Asim Surani, shares how his extensive research has significantly advanced the understanding of how the mammalian germline is specified, the mechanisms governing epigenetic r...

19 Juni 202556min

Exploring DNA Methylation and TET Enzymes in Early Development (Petra Hajkova)

Exploring DNA Methylation and TET Enzymes in Early Development (Petra Hajkova)

In this episode of the Epigenetics Podcast, we talked with Petra Hajkova from the MRC Laboratory of Medical Sciences about her work on epigenetics research on mammalian development, highlighting DNA m...

5 Juni 202539min

Epigenetic Regulation and Small Molecule Innovation in AML: Advances in Translational Leukemia Research (Ani Deshpande)

Epigenetic Regulation and Small Molecule Innovation in AML: Advances in Translational Leukemia Research (Ani Deshpande)

In this episode of the Epigenetics Podcast, we talked with Ani Deshpande from Sanford Burnham Prebys about his work on epigenetic regulation and developing small molecules through high throughput scre...

22 Maj 20251h

Beyond Mom: Rethinking Paternal Influence in Epigenetic Inheritance (Raffaele Teperino)

Beyond Mom: Rethinking Paternal Influence in Epigenetic Inheritance (Raffaele Teperino)

In this episode Dr. Raffaele Teperino shares insights from his ongoing research focused on developmental programming, particularly how paternal health before conception influences not only offspring h...

8 Maj 202559min

Evolutionary Epigenetic Clocks and Epigenetic Inheritance in Plants (Frank Johannes)

Evolutionary Epigenetic Clocks and Epigenetic Inheritance in Plants (Frank Johannes)

In this episode of the Epigenetics Podcast, we talked with Dr. Frank Johannes from the Technical University of Munich in Freising about his work on evolutionary clocks and epigenetic inheritance in pl...

24 Apr 202539min

Neuroepigenetic Mechanisms and Primate Epigenome Evolution (Boyan Bonev)

Neuroepigenetic Mechanisms and Primate Epigenome Evolution (Boyan Bonev)

In this episode of the Epigenetics Podcast, we talked with Boyan Bonev from the HelmholtzZetrum in Munich about his work on neuroepigenetics, focusing on gene regulation, chromatin architecture, and p...

10 Apr 202545min

The Role of H3K4me3 in Embryonic Development (Eva Hörmanseder)

The Role of H3K4me3 in Embryonic Development (Eva Hörmanseder)

In this episode of the Epigenetics Podcast, we talked with Dr. Eva Hörmanseder from the HelmholtzZentrum in Munich about her work on epigenetic mechanisms in cellular memory and gene regulation. In th...

27 Mars 202537min

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