Influence of Histone Variants on Chromatin Structure and Metabolism (Markus Buschbeck)

Influence of Histone Variants on Chromatin Structure and Metabolism (Markus Buschbeck)

In this episode of the Epigenetics Podcast, we sat down with Marcus Buschbeck, Group Leader at the Josep Carreras Leukaemia Research Institute in Barcelona, to talk about his work on the histone variant macroH2A, its role in metabolism and how it contributes to the regulation of chromatin structure.

Histone variants equip chromatin with unique properties and show a specific genomic distribution. The histone variant macroH2A is unique in having a tripartite structure consisting of a N-terminal histone-fold, an intrinsically unstructured linker domain and a C-terminal macro domain. Recent discoveries show that macroH2A proteins have a major role in the nuclear organization which has the potential to explain how these proteins can act as tumor suppressors, promoters of differentiation and barriers to somatic cell reprogramming.

We discuss these topics, the mission of the Josep Carreras Leukaemia Research Institute, and much more in this episode.

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Nucleosome Positioning in Cancer Diagnostics (Vladimir Teif)

Nucleosome Positioning in Cancer Diagnostics (Vladimir Teif)

In this episode of the Epigenetics Podcast, we caught up with Vladimir Teif from the University of Essex to talk about his work on nucleosome positioning in development and disease. Vladimir's researc...

5 Sep 202440min

The Effect of Histone Demethylases on Gene Expression and Cancer Cell Stability (Johnathan Whetstine)

The Effect of Histone Demethylases on Gene Expression and Cancer Cell Stability (Johnathan Whetstine)

In this episode of the Epigenetics Podcast, we talked with Johnathan Whetstine from Fox Chase Cancer Center about his work on how histone demethylases affect gene expression and cancer cell stability....

29 Aug 202439min

Stem Cell Transcriptional Regulation in Naive vs. Primed Pluripotency (Christa Buecker)

Stem Cell Transcriptional Regulation in Naive vs. Primed Pluripotency (Christa Buecker)

In this episode of the Epigenetics Podcast, we talked with Christa Buecker from the Max Perutz Laboratories in Vienna about her work on transcriptional regulation during early embryonic development. D...

8 Aug 202436min

Gene Expression Control and Intricacies of X-chromosome Inactivation (Claire Rougeulle)

Gene Expression Control and Intricacies of X-chromosome Inactivation (Claire Rougeulle)

In this episode of the Epigenetics Podcast, we talked with Claire Rougeulle from the Epigenetics and Cell Fate Center at Université Paris City about her work on gene expression control, the intricacie...

25 Juli 202438min

Epigenetic Mechanisms in Genome Regulation and Developmental Programming (James Hackett)

Epigenetic Mechanisms in Genome Regulation and Developmental Programming (James Hackett)

In this episode of the Epigenetics Podcast, we talked with James Hackett from the EMBL in Rome about his work on epigenetic mechanisms in genome regulation and developmental programming. One of James ...

11 Juli 202437min

Advanced Optical Imaging in 3D Nuclear Organisation (Lothar Schermelleh)

Advanced Optical Imaging in 3D Nuclear Organisation (Lothar Schermelleh)

In this episode of the Epigenetics Podcast, we talked with Lothar Schermelleh from the University of Oxford about his work on advanced optical imaging in 3D nuclear organisation.  The interview start...

27 Juni 202446min

DNA Replication, Transcription and R-loops (Stephan Hamperl)

DNA Replication, Transcription and R-loops (Stephan Hamperl)

In this episode of the Epigenetics Podcast, we talked with Dr. Stephan Hamperl from the Helmholtz Zentrum Munich about his work on how conflicts between transcription, replication, and R-loop formatio...

13 Juni 202434min

Mutations of Gene Regulatory Elements in Human Disease (Nadav Ahituv)

Mutations of Gene Regulatory Elements in Human Disease (Nadav Ahituv)

In this episode of the Epigenetics Podcast, we talked with Nadav Ahituv from University of California, San Francisco about his work on mutations of gene regulatory elements in human disease. Using mas...

30 Maj 202449min

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