The Role of PHF13 in Chromatin and Transcription (Sarah Kinkley)

The Role of PHF13 in Chromatin and Transcription (Sarah Kinkley)

In this episode of the Epigenetics Podcast, we caught up with Sarah Kinkley from the Max Planck Institute of Molecular Genetics to talk about her work on PHF13 and its role in chromatin and transcription.

The Kinkley laboratory focuses mainly on unraveling the mechanism of action of the transcription factor PHF13 (PHC Finger Protein 13). PHF13 is a reader of the epigenetic mark H3K4 trimethylation which influences higher chromatin order, transcriptional regulation, and differentiation. The lab has shown that PHF13 plays a crucial role in phase separation and mitotic chromatin compaction.

References

  • Kinkley, S., Staege, H., Mohrmann, G., Rohaly, G., Schaub, T., Kremmer, E., Winterpacht, A., & Will, H. (2009). SPOC1: a novel PHD-containing protein modulating chromatin structure and mitotic chromosome condensation. Journal of cell science, 122(Pt 16), 2946–2956. https://doi.org/10.1242/jcs.047365

  • Chung, H. R., Xu, C., Fuchs, A., Mund, A., Lange, M., Staege, H., Schubert, T., Bian, C., Dunkel, I., Eberharter, A., Regnard, C., Klinker, H., Meierhofer, D., Cozzuto, L., Winterpacht, A., Di Croce, L., Min, J., Will, H., & Kinkley, S. (2016). PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3. eLife, 5, e10607. https://doi.org/10.7554/eLife.10607

  • Connecting the Dots: PHF13 and cohesin promote polymer-polymer phase separation of chromatin into chromosomes. Francesca Rossi, Rene Buschow, Laura V. Glaser, Tobias Schubert, Hannah Staege, Astrid Grimme, Hans Will, Thorsten Milke, Martin Vingron, Andrea M. Chiariello, Sarah Kinkley. bioRxiv 2022.03.04.482956; doi: https://doi.org/10.1101/2022.03.04.482956

Related Episodes

Avsnitt(168)

Multimodal Characterization of Cellular Identity | CITE-Seq and Beyond (Peter Smibert, VP of 10X Genomics)

Multimodal Characterization of Cellular Identity | CITE-Seq and Beyond (Peter Smibert, VP of 10X Genomics)

In this episode of the Epigenetics Podcast, we speak with Peter Smibert, Vice President of Biology at 10X Genomics to talk about an exciting new method in Multimodal Characterization of Cellular Ident...

14 Apr 202248min

The Effect of Mechanotransduction on Chromatin Structure and Transcription in Stem Cells (Sara Wickström)

The Effect of Mechanotransduction on Chromatin Structure and Transcription in Stem Cells (Sara Wickström)

In this episode of the Epigenetics Podcast, we caught up with Sara Wickström, Director at the Max Planck Institute for Molecular Biomedicine in Münster, to talk about her work on the effect of mechano...

31 Mars 202230min

Single-Cell Technologies using Microfluidics (Ben Hindson, CSO of 10x Genomics)

Single-Cell Technologies using Microfluidics (Ben Hindson, CSO of 10x Genomics)

In this episode of the Epigenetics Podcast, we caught up with Ben Hindson, Chief Scientific Officer at 10X Genomics, to talk about single-cell technologies using microfluidics. Epigenetics has moved ...

16 Mars 202238min

Epigenome-based Precision Medicine (Eleni Tomazou)

Epigenome-based Precision Medicine (Eleni Tomazou)

In this episode of the Epigenetics Podcast, we caught up with Eleni Tomazou from St. Anna Children's Cancer Research Institute in Vienna to talk about her work on Epigenome-based precision medicine. T...

10 Mars 202240min

Epigenetics and Epitranscriptomics in Cancer (Manel Esteller)

Epigenetics and Epitranscriptomics in Cancer (Manel Esteller)

In this episode of the Epigenetics Podcast, we caught up with Manel Esteller, Director of the Josep Carreras Leukemia Research Institute to talk about his work on Epigenetics and Epitranscriptomics in...

24 Feb 202234min

Enhancer-Promoter Interactions During Development (Yad Ghavi-Helm)

Enhancer-Promoter Interactions During Development (Yad Ghavi-Helm)

In this episode of the Epigenetics Podcast, we caught up with Yad Ghavi-Helm from the Institut de Génomique Functionnelle de Lyon to talk about her work on enhancer-promoter interactions during develo...

10 Feb 202228min

The Effect of Vitamin D on the Epigenome (Folami Ideraabdullah)

The Effect of Vitamin D on the Epigenome (Folami Ideraabdullah)

In this episode of the Epigenetics Podcast, we caught up with Folami Ideraabdullah from the University of Chapel Hill to talk about her work on the environmental modulation of the epigenome during dev...

27 Jan 202236min

H3K4me3, Set-Proteins, Isw1 and their Role in Transcription (Jane Mellor)

H3K4me3, Set-Proteins, Isw1 and their Role in Transcription (Jane Mellor)

In this episode of the Epigenetics Podcast, we caught up with Jane Mellor from the University of Oxford to talk about her work on H3K4me3, SET proteins, Isw1 and their role in transcription. Since the...

13 Jan 202242min

Populärt inom Vetenskap

p3-dystopia
svd-nyhetsartiklar
pojkmottagningen
dumma-manniskor
allt-du-velat-veta
kapitalet-en-podd-om-ekonomi
det-morka-psyket
rss-vetenskapsradion
rss-ufo-bortom-rimligt-tvivel
rss-experimentet
paranormalt-med-caroline-giertz
medicinvetarna
bildningspodden
halsorevolutionen
rss-vetenskapsradion-2
4health-med-anna-sparre
rss-spraket
hacka-livet
rss-broccolipodden-en-podcast-som-inte-handlar-om-broccoli
sexet