Structural Analysis of Nucleosomes During Transcription (Lucas Farnung)

Structural Analysis of Nucleosomes During Transcription (Lucas Farnung)

In this episode of the Epigenetics Podcast, we caught up with Lucas Farnung from Harvard Medical School to talk about his work on the structural analysis of nucleosomes during transcription.

Lucas Farnung started his scientific career in Patrick Cramer's lab, trying to solve the cryo-EM structure of RNA polymerase II transcribing through a nucleosome. This project spanned some time before being published in 2018, during which time Dr. Farnung accomplished several other goals. The team solved the cryo-electron microscopy structure of Chd1 from the yeast Saccharomyces cerevisiae bound to a nucleosome at a resolution of 4.8 Å, solved the structure of the nucleosome-CHD4 chromatin remodeler, and investigated the structural basis of nucleosome transcription mediated by Chd1 and FACT. In 2021, he started his own lab and is now working on structural analysis of nucleosomes during transcription and how chromatin remodelers work on the chromatin template.

References

  • Farnung, L., Vos, S. M., Wigge, C., & Cramer, P. (2017). Nucleosome-Chd1 structure and implications for chromatin remodelling. Nature, 550(7677), 539–542. https://doi.org/10.1038/nature24046

  • Farnung, L., Vos, S. M., & Cramer, P. (2018). Structure of transcribing RNA polymerase II-nucleosome complex. Nature communications, 9(1), 5432. https://doi.org/10.1038/s41467-018-07870-y

  • Filipovski, M., Soffers, J. H. M., Vos, S. M., & Farnung, L. (2022). Structural basis of nucleosome retention during transcription elongation. Science (New York, N.Y.), 376(6599), 1313–1316. https://doi.org/10.1126/science.abo3851

Related Episodes

Avsnitt(171)

The Role of SMCHD1 in Development and Disease (Marnie Blewitt)

The Role of SMCHD1 in Development and Disease (Marnie Blewitt)

In this episode of the Epigenetics Podcast, we caught up with Marnie Blewitt from the Walter and Eliza Hall Institute of Medical Research to talk about her work on the role of SMCHD1 in Development an...

14 Okt 202130min

Single-Molecule Imaging of the Epigenome (Efrat Shema)

Single-Molecule Imaging of the Epigenome (Efrat Shema)

In this episode of the Epigenetics Podcast, we caught up with Efrat Shema from the Weizmann Institute of Science to talk about her work on Single Molecule Imaging of chromatin, and the analysis of nuc...

30 Sep 202139min

Heterochromatin Protein 1 and its Influence on the Structure of Chromatin (Serena Sanulli)

Heterochromatin Protein 1 and its Influence on the Structure of Chromatin (Serena Sanulli)

In this episode of the Epigenetics Podcast, we caught up with Serena Sanulli from Stanford University to talk about her work on Heterochromatin Protein 1 (HP1), the structure of chromatin on the atomi...

16 Sep 202131min

The Effects of Early Life Stress on Mammalian Development (Catherine J. Peña)

The Effects of Early Life Stress on Mammalian Development (Catherine J. Peña)

In this episode of the Epigenetics Podcast, we caught up with Catherine Jensen Peña from Princeton University to talk about her work on early life stress and its effects on behavior. The Laboratory o...

2 Sep 202136min

Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard)

Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard)

In this episode of the Epigenetics Podcast, we caught up with Ali Shilatifard from Northwestern University to talk about his work on targeting COMPASS to cure childhood leukemia. The Shilatifard Lab ...

19 Aug 202141min

Effects of Non-Enzymatic Covalent Histone Modifications on Chromatin (Yael David)

Effects of Non-Enzymatic Covalent Histone Modifications on Chromatin (Yael David)

In this episode of the Epigenetics Podcast, we caught up with Yael David from Memorial Sloan Kettering Cancer Center in New York to talk about her work on Effects of Non-Enzymatic Covalent Histone Mod...

5 Aug 202134min

ATAC-Seq, scATAC-Seq and Chromatin Dynamics in Single-Cells (Jason Buenrostro)

ATAC-Seq, scATAC-Seq and Chromatin Dynamics in Single-Cells (Jason Buenrostro)

In this episode of the Epigenetics Podcast, we caught up with Jason Buenrostro from Harvard University to talk about his work on developing biological tools to measure chromatin dynamics in single-cel...

22 Juli 202147min

Synthetic Chromatin Epigenetics (Karmella Haynes)

Synthetic Chromatin Epigenetics (Karmella Haynes)

In this episode of the Epigenetics Podcast, we caught up with Karmella Haynes from Emory University to talk about her work on synthetic chromatin epigenetics. The Haynes lab focuses on the design of ...

8 Juli 202144min

Populärt inom Vetenskap

svd-nyhetsartiklar
dumma-manniskor
p3-dystopia
kapitalet-en-podd-om-ekonomi
allt-du-velat-veta
doden-hjarnan-kemisten
rss-ufo-bortom-rimligt-tvivel-2
rss-vetenskapsradion-2
rss-vetenskapsradion
det-morka-psyket
sexet
bildningspodden
medicinvetarna
paranormalt-med-caroline-giertz
rss-spraket
rss-experimentet
har-vi-akt-till-mars-an
dumforklarat
rss-odla
rss-tidsmaskinen