Biohacking Alzheimers, Age Reversal, Young Blood, Stem Cells, Exosomes & More!
Boundless Life20 Sep 2018

Biohacking Alzheimers, Age Reversal, Young Blood, Stem Cells, Exosomes & More!

You've no doubt heard of it by now...

In an attempt to live longer, some anti-aging enthusiasts are getting themselves injected with the blood of young humans, via a process deemed: plasmaphoresis.

This podcast is about several age reversal therapies. It's also about biohacking Alzheimers. It's about all these therapies (senolytics, exosomes, gdf-11, etc) that scientists have been talking about for age reversal. The podcast is about biological aging clocks and biomarkers to measure them. You'll learn about ways that you can biohack Alzheimer's disease, how to measure your biological age, how to reverse aging, what the biggest obstacle to age reversal is, how to get more involved in the anti-aging community and more.

About the Guests

Mark Urdahl, is a technology entrepreneur from the Silicon Valley. He has numerous patents and has worked in big data. He began his career at IBM's medical instruments subsidiary that pioneered plasmaphoresis. Mark founded the Youngblood Institute to advance new uses for well established therapeutic plasma exchange therapies which have recently evidenced a previously undocumented potential to rejuvenate the body's own stem cells, restore aging immune systems, and prevent the onset of many age-related disease condition, so that we might live healthy as we age and ultimately live longer lives.

Tom Ingloglia first appeared on this podcast in the episode "The Next Big Anti-Aging Drug: Everything You Need To Know About “NAD”." As you learn in that episode, Tom is a private investor with a master’s degree in finance. In the midst of trading, investing in technology and developing real estate in Costa Rica, Tom became very sick. He was initially prescribed antibiotics, suffered from an adverse reaction and was told that he’d have stomach problems for the rest of his life. In the years that followed, Tom also developed severe food allergies. His symptoms worsened, and he next began dealing with insomnia, anxiety, muscle pain, tendinopathies, joint pain, chronic fatigue syndrome, altered and clouded cognition and headaches. He finally had a mental breakdown in 2008.

After a prolonged period of taking antibiotics, Tom began experiencing tendonitis throughout his fingers, hands, wrists and ankles and feet, so he started taking pain medications to relieve this pain. He had to give up his career in trading because his sole focus for the next eight years would be on finding a cure to his growing symptoms. His life consisted of working with physical therapists, going to the gym, going to new doctors, and trying new foods to see if it would help. Throughout Tom’s eight-year battle, he was prescribed consistently and persistently more medication.

For six years, he was taking excessive amounts of Hydrocodone and Tramadol every day. Tom became obsessed with researching symptoms and treatments, and learned about the NAD+ treatment. He visited a clinic, and on Day 7 of his treatment, “It hit me. I started feeling better. I felt amazing. There was a calm that came over me. I felt safe. I just had no cravings for drugs or pain meds. There was no need for them. I just didn’t have the excruciating pain that I had before. I felt eight years of pain melting away.” Tom has nearly fully recovered, using related treatments to NAD+, and has engaged two cofounders to assist him in building out a facility to help bring this treatment to others in similar situations.

In my conversation with Mark and Tom, you'll discover:

-The history of The Young Blood Institute and how "heterochronic plasma exchange" works...16:00

  • Heterochronic plasma means simply removing old plasma and replacing it with "young" plasma.
  • Others are experimenting with this concept.
  • What Mark does is different from a plasma "infusion."
  • Plasma is approximately half of our blood volume.
  • Mark began with IBM Biomedical Systems, who had invented what we now call the "blood cell processor."

-The intricate means of testing used on mice...22:15

  • Basically creating "siamese twins" with mice by stitching them together.
  • Similar procedures have been conducted on humans for over 50 years.
  • Mark wanted to recruit the best medical professionals to the Young Blood Institute. Many of them have been doing it for 30-40 years.

-What, if any, are the risks of these plasma exchanges...29:10

  • Roughly a 4% risk of a transfusion reaction, which is akin to what you might experience donating blood.
  • One of the safer procedures in the medical field today.
  • You go through 6 exchanges as part of a protocol.

-The network of doctors that Mark and Tom have built to do a plasma exchange...32:42

  • There are medical professionals all over the U.S. that can do the procedure.
  • Submit an inquiry on the Young Blood Institute website to find a doctor that is near you.

-What anti-aging biomarkers Mark is tracking at the Young Blood Institute...34:51

  • They have more technology testing capability than Stanford, Johns Hopkins and Harvard combined.
  • Key technology: time of flight mass cytometry. Single cell proteionomics.
  • They are trying to develop early detection biomarkers that enables them to prevent the onset of diseases before they become significant.

-The lowest hanging fruit for people to track...46:15

  • The YBI's concern is the function of the body, rather than the age.
  • Your cells are not aware of your "age".

-What a biological aging clock is...50:20

  • Zymo is a lab that has worked with Steven Horvath. Zymo DNA Methylation Aging Clock
  • Looked at DNA, and seen a pattern from methyl groups attached to certain parts of the genome.

-How can we track biological aging, or slow down our biological aging clock?...52:30

  • Inflammatory markers, heart age, brain age, lung age, skin elasticity.

-The anti-aging booth that Mark and Tom will be operating at a conference called RAAD Fest...54:45

  • Revolution Against Aging and Death
  • Want to have a contest where people calculate their age, and track their progress.
  • Mark and Tom have one of the largest booths at the conference.

-Whether NAD actually gets absorbed into a cell via injections or IV...1:00:30

  • How does Ben feel with an injection? Answer: Incredible.
  • Tom doesn't recommend the injection due to the level of discomfort.

-Why compounded formulas such as glutathione and Vitamin B could be taken off the market soon...1:07:30

  • There's a review similar to a court hearing, where people argue for and against glutathione.
  • Taken off the market for compounding pharmacies.
  • Tom "has his own reasons" for why this could be deemed unsafe.
  • Core problem: the vitamins don't have any intellectual property. Could affect the costs of healthcare.

-How to use technologies such as Vielight and exosomes to address Alzheimer's...1:14:30

  • Alzheimers is a $500 billion industry; the 6th leading cause of death.
  • A Vielight is basically a laser light for your nose and head; photobiomodulation on your skull.

-What GDF11 mRNA is and how it works to improve hearing, smell and sight...1:25:30

  • GDF11 is a DNA repair molecule; makes stem cells active again.
  • Patients see improvements in sex drive, vision, smell, hearing, etc.
  • Legal hurdles to being able to administer it.
  • "Unofficial" results are very positive.

-How senolytics works as a therapy for aging and Alzheimer's, and the importance of quercetin and tocotrienols...1:33:45

  • Describes small molecules that lead to the death of "zombie" cells that don't help the rest of your body.
  • Life Extension article "Natural Compounds that Remove Aging Cells"

-And much more...

Resources from this episode:

-The NAD Treatment Center -NAD conference -Brain Research Center -The Revolutionary RX Podcast -Beyond NAD Conference - Use discount code "BenlovesNAD" at check out

-Connexin 43 hemi channels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells

-3T3 L1 Cell Line from mouse

-PRESERVING PATIENT ACCESS TO COMPOUNDED MEDICATIONS H.R. 2871 -Bulk Drug Substances Nominated for Use in Compounding Under Section 503B of the Federal Food, Drug, and Cosmetic Act

-Forecasting the global burden of Alzheimer’s disease

-Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models

-Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss.

-Nicotinamide restores cognition in AD transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau

-Dr Nady Braidy

-Alzheimer’s Disease Statistics

-The Bredesen Protocol

-Book: The End of Alzheimer’s: The First Program to Prevent and Reverse Cognitive Decline by Dr. Dale Bredesen -The Vielight -Exosomes Podcast: The Single, Most Comprehensive Stem Cell Procedure Known To Humankind: How A "Full Body Stem Cell & Exosome Makeover" Works.

-Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases

-Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. -Steve Perry's GDF11 Presentation at RAADFest 2017

-Stressed, toxic, zombie cells seen for 1st time in Alzheimer's

-Tau protein aggregation is associated with cellular senescence in the brain

-Quercetin and Tocotrienols - 500-800mg Quercetin and 150mg tocotrienols per day for 3 months -New study on whether NAD is absorbed into cell via IV

Episode Sponsors:

-Kion Aminos Whether you’re looking to stimulate faster muscle growth, recover more rapidly from exercise, become more resistant to fatigue during a grueling workout, or just benefit from additional amino acids in their most absorbable form to support aging or a vegan, vegetarian, or ketosis diet, Kion Aminos essential amino acids has you covered.

-Gluten Guardian "How to eat gluten and get away with it..." Get 10% off the already discounted price when you use my link!

-Thrive Market Makes healthy living easy and affordable at 25-50% off traditional retail prices. Use my link and get an additional $60 off your order.

-Gainswave The revolutionary bedroom biohack for guys who want optimal sexual performance.

Do you have questions, thoughts or feedback for Tom, Mark or me? Leave your comments below and one of us will reply!

See omnystudio.com/listener for privacy information.

Avsnitt(1746)

How To Train Your Brain Like A Muscle: Mental Fitness SECRETS (& A Headband That Makes You Smarter!) with Ariel Garten of Muse

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Full Shownotes: https://bengreenfieldlife.com/podcast/athena/ My guest on this podcast is Ariel Garten, the founder of InteraXon, maker of Muse. Ariel studied neuroscience at the University of Toronto and worked in labs at Toronto’s Krembil Neuroscience Centre, researching Parkinson’s disease and hippocampal neurogenesis. No mere science nerd, Ariel is a fashion designer whose clothing opened Toronto Fashion Week in 2003 and has had her work displayed at the Art Gallery of Ontario. Ariel’s distinctive combination of science and art is integral to the design of Muse and to InteraXon’s unique approach to brain sensing technology. As a neuroscientist and former psychotherapist, Ariel Garten witnessed firsthand the struggles many face with mental health and the search for effective, accessible solutions. Inspired to make a real difference, she channeled her expertise into co-founding Muse, a healthtech startup aimed at revolutionizing brain health through technology. Use code BENGREENFIELD for a special discount on Muse's website. Episode Sponsors: Muse: Muse S Athena combines clinical-grade EEG and fNIRS technology to train your brain in real time while tracking sleep with 86% expert-level accuracy. Get 15% off at choosemuse.com/BENGREENFIELD or use code BENGREENFIELD at checkout. BiOptimizers Holiday Offer: Trust me when I say this – you won't find a better Black Friday deal anywhere else, not even on the mighty Amazon. The biggest discount you can get and amazing gifts with purchase are available only on my page bioptimizers.com/ben with code BEN15. BON CHARGE: BON CHARGE is a holistic wellness brand with a wide range of products that naturally address the issues of modern life. Their products can help you sleep better, perform better, recover faster, balance hormones, reduce inflammation, and so much more. Go to boncharge.com/GREENFIELD and use coupon code GREENFIELD to save 15%. Organifi Shilajit Gummies: Harness the ancient power of pure Himalayan Shilajit anytime you want with these convenient and tasty gummies. Get them now for 20% off at organifi.com/Ben. LMNT: Everyone needs electrolytes, especially those on low-carb diets, who practice intermittent or extended fasting, are physically active, or sweat a lot. Go to DrinkLMNT.com/BenGreenfield to get a free sample pack with your purchase! Quantum Upgrade: Recent research has revealed that the Quantum Upgrade was able to increase ATP production by a jaw-dropping 20–25% in human cells. Unlock a 15-day free trial with the code BEN15 at quantumupgrade.io. Troscriptions: Explore Troscriptions' revolutionary buccal troche delivery system that bypasses digestion to deliver pharmaceutical-grade, physician-formulated health optimization compounds directly through your cheek mucosa for faster onset and higher bioavailability than traditional supplements. Discover a completely new way to optimize your health at troscriptions.com/BEN or enter BEN at checkout for 10% off your first order.See omnystudio.com/listener for privacy information.

27 Nov 202540min

The TRUTH About What's *Really* Causing Your Fatigue & The "Root Cause" Protocol to Fix It, With Morley Robbins.

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22 Nov 20251h 6min

How Long Does It Take To Get "FAT ADAPTED", Is Insulin Good or Bad, How Many Carbs Do You *Really* Need & More With Dr. Andrew Koutnik.

How Long Does It Take To Get "FAT ADAPTED", Is Insulin Good or Bad, How Many Carbs Do You *Really* Need & More With Dr. Andrew Koutnik.

Full Show Notes: https://bengreenfieldlife.com/drandrew Dr. Andrew Koutnik is a research scientist whose career bridges cutting-edge science, elite performance, and personal experience living with type 1 diabetes for over 17 years. His work focuses on how nutrition, metabolism, and lifestyle can be leveraged to maximize human health, performance, and resilience across diverse conditions—from chronic disease to extreme environments. Dr. Andrew Koutnik earned his Ph.D. in Medical Sciences (Molecular Pharmacology and Physiology) from the University of South Florida Morsani College of Medicine. Prior to joining FSU, Dr. Andrew Koutnik served as a Faculty/Principal Investigator at Sansum Diabetes Research Institute and Florida Institute for Human and Machine Cognition. His research has spanned over $70,000,000 in research funding, including NASA missions, U.S. Special Operations Command, Defense Advanced Research Projects, Office of Naval Research, Department of Defense, and NIH-funded clinical trials Episode Sponsors: LVLUP Health: I trust and recommend LVLUP Health for your peptide needs as they third-party test every single batch of their peptides to ensure you’re getting exactly what you pay for and the results you’re after! Head over to lvluphealth.com/BGL and use code BEN15 for a special discount on their game-changing range of products. Ketone-IQ: Ketones are a uniquely powerful macronutrient that can cross the blood-brain barrier and increase brain energy and efficiency. With a daily dose of Ketone-IQ, you'll notice a radical boost in focus, endurance, and performance. Save 30% off your first subscription order of Ketone-IQ at Ketone.com/BENG. CAROL Bike: The science is clear—CAROL Bike is your ticket to a healthier, more vibrant life. And for a limited time, you can get $100 off yours with the code BEN. Don't wait any longer, join over 25,000 riders and visit carolbike.com/ben today. Sunlighten: Sunlighten's patented infrared sauna technology delivers the highest quality near, mid, and far infrared wavelengths to reduce inflammation, boost mitochondrial function, enhance detox pathways, and optimize recovery—backed by 25+ years of clinically proven, non-toxic innovation. Save up to $1,400 at Sunlighten.com/BEN with code BEN. Gameday Men’s Health: Gameday Men's Health offers science-backed, physician-led men's health optimization with personalized protocols for testosterone, peptide therapy, ED treatment, and more—helping you perform at your best whether you're training hard or keeping up with life. Visit gamedaymenshealth.com/bengreenfield for a free testosterone test and consultation at a clinic near you. Boundless Bar: If you’re ready to fuel workouts, sharpen your focus, and support whole-body vitality, grab your Boundless Bars now at boundlessbar.com —and save 10% when you sign up for a Boundless Bar subscription.See omnystudio.com/listener for privacy information.

20 Nov 20251h 12min

Everything You Need To Know About Sleeping Better, Hacking Sleep, Sleep Cycles, Insomnia, Sleep Apnea & More With Dr. Daniel Gartenberg (Best of LIFE Network's Experts!)

Everything You Need To Know About Sleeping Better, Hacking Sleep, Sleep Cycles, Insomnia, Sleep Apnea & More With Dr. Daniel Gartenberg (Best of LIFE Network's Experts!)

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15 Nov 20251h 26min

Are YOU Taking Too Many Supplements, Doing Too Much Ice Bathing Or Eating the Wrong Diet? (Here's How To Know!) With MeScreen's Sean Fetcho & Dr. Luis Fandos

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Full Show Notes: https://bengreenfieldlife.com/versea/ Several months ago, I released the episode “A Brand New, At-Home Way To Accurately Test Your *Mitochondrial* Health & Efficiency (Your Doctor Probably HASN’T Heard Of This!) With Dr. Hemal Patel”. Since then, I have received many questions about the MeScreen test by Versea Health that Dr Patel and I discussed in that episode. During this podcast, I’ll be taking a deep dive into how to test your mitochondria and optimize cellular function based on what you find. My first guest on this show, Sean Fetcho, is the co-founder and CEO of Verséa Health, the parent company of Verséa Discovery, the creators of MeScreen™. Sean Fetcho leads with a clear vision: to revolutionize health optimization by putting mitochondrial health testing at the forefront of preventative care. By fostering a dynamic culture of collaboration and forward-thinking, he ensures MeScreen stays ahead in delivering groundbreaking health solutions, redefining the landscape of personalized healthcare. My other guest on this show is Dr. Luis Fandos, MD, ABAPM, who is a highly respected interventional pain management specialist and the founder of Alluring Age. Dr. Fandos is a pioneer in integrating functional and cellular medicine into traditional pain management. His practice includes advanced therapies such as genetic testing, peptide protocols, hormone optimization, and vagus nerve stimulation—backed by certification from the Vagus Nerve Society. https://bengreenfieldlife.com/mescreen - link will automatically apply $150 off Click here to view a sample MeScreen report Episode Sponsors: BEAM Minerals: If you want to up your mineral game, give BEAM Minerals a try. Go to beamminerals.com and use code BEN at checkout for 20% off your order. Quantum Upgrade: Recent research has revealed that the Quantum Upgrade was able to increase ATP production by a jaw-dropping 20–25% in human cells. Unlock a 15-day free trial with the code BEN15 at quantumupgrade.io. RA Optics: Give the gift of better sleep, sharper focus, and vibrant energy this holiday season with Ra Optics. Go to raoptics.com/BEN10 and use code BEN10 for 10% Off. Just Thrive: For a limited time, you can save 20% off a 90 day bottle of Just Thrive Probiotic and Just Calm at justthrivehealth.com/ben with promo code: BEN. That’s like getting a month for FREE! Take control today with Just Thrive! Ultimate Longevity: Struggling with chronic pain and inflammation? Try out Ultimate Longevity's Ground Therapy Sleep Mat and Pillowcase to experience improved sleep, cellular function, HRV, and dramatic pain and inflammation reduction. Go to bengreenfieldlife.com/ultimate-longevity to save up to 15% on Sleep Mat & Pillowcase Combo Packs + Get a FREE copy of the paperback book "Earthing" with every Combo Pack. Boundless Bar: Fuel your body and brain with Boundless Bar—the world’s first goBHB®-powered protein bar designed for sustained energy, mental focus, and metabolic health. Made with collagen protein, nut butters, and clean ketones, it supports performance, recovery, and all-day vitality. Grab yours now at boundlessbar.com—and enjoy 10% off when you subscribe.See omnystudio.com/listener for privacy information.

13 Nov 20251h 3min

Practical Hacks For Making New Habits, Waging The War Against Alcohol, The Best Morning Routine Ever, Upgraded Overnight Oatmeal & Much More With Michael Chernow (Best of LIFE Network's Experts!)

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8 Nov 20251h 47min

Stem Cells For Longevity & Performance: The Untold Truth About Domestic vs. International Treatments! with Dr Harry Adelson and Dr Amy Killen

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6 Nov 202552min

Exercising One Specific (Often Forgotten) Body Part Can Relieve Aching Tightness, Head-Splitting Migraines, Breathing Issues, and Poor Sleep Quality With Dr. Neel Bulchandani  (Best of LIFE Network's Experts!)

Exercising One Specific (Often Forgotten) Body Part Can Relieve Aching Tightness, Head-Splitting Migraines, Breathing Issues, and Poor Sleep Quality With Dr. Neel Bulchandani (Best of LIFE Network's Experts!)

Full Show Notes: https://bengreenfieldlife.com/lnneel/ Aching tightness, head-splitting migraines, breathing issues, and poor sleep quality — these are all signs of trapped tension in your body. The good news is that exercising one specific (and often forgotten) body part can help restore your well-being… I'm talking about your tongue… I first discovered how to unlock the power of whole-body tension relief when Dr. Neel Bulchandani visited my house and did some very unique body therapy on me (including putting his fingers into my mouth and my nasal cavity to 'adjust' those sections)! I later released an Instagram post about his groundbreaking Tongue Press program — a video series and guide designed to optimize tongue mobility. Dr. Bulchandani is a holistic chiropractor and bodywork educator who has poured over 15 years of chiropractic expertise and five years of training fellow bodyworkers into creating not just Tongue Press, but his other unique methods as well. *If you want to try his Tongue Press program, you'll receive a masterclass packed with videos, audio, and a detailed PDF guide. Plus, you get months of Dr. Bulchandani ‘s exclusive newsletter, all with a special 30% discount, by using code BenAirway here. Episode Sponsors: Timeline Nutrition: Give your cells new life with high-performance products powered by Mitopure, Timeline's powerful ingredient that unlocks a precise dose of the rare Urolithin A molecule and promotes healthy aging. Go to shop.timeline.com/BEN and use code BEN to get 20% off your order. BiOptimizers Holiday Offer: Trust me when I say this – you won't find a better Black Friday deal anywhere else, not even on the mighty Amazon. The biggest discount you can get and amazing gifts with purchase are available only on my page bioptimizers.com/ben with code BEN15. Quantum Upgrade: Recent research has revealed that the Quantum Upgrade was able to increase ATP production by a jaw-dropping 20–25% in human cells. Unlock a 15-day free trial with the code BEN15 at quantumupgrade.io. Organifi Shilajit Gummies: Harness the ancient power of pure Himalayan Shilajit anytime you want with these convenient and tasty gummies. Get them now for 20% off at organifi.com/Ben. BlockBlueLight: BlockBlueLight BioLights are the only lights extensively tested and recommended by building biologist Brian Hoyer as truly flicker-free, ultra-low EMF, and circadian-friendly, with three modes (day, evening, night) that support natural rhythms and optimize sleep quality. Get 10% off your first order at blockbluelight.com/Ben(discount autoapplied at checkout). Boundless Bar: Fuel your body and brain with Boundless Bar—the world’s first goBHB®-powered protein bar designed for sustained energy, mental focus, and metabolic health. Grab yours now at boundlessbar.com—and enjoy 10% off when you subscribe. 🎧 Want to Hear More from Dr Neel Bulchandani? Click Here to Join LIFE Network for FreeSee omnystudio.com/listener for privacy information.

1 Nov 20251h 6min

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