Everything You've Ever Wanted To Know About Fish Oil, Omega 3 Fatty Acids, EPA, DHA & Much More!
Boundless Life21 Nov 2020

Everything You've Ever Wanted To Know About Fish Oil, Omega 3 Fatty Acids, EPA, DHA & Much More!

https://bengreenfieldfitness.com/fishoilpodcast

After publishing my recent giant fish oil article "A Deep "Dive" Into The Fascinating World Of Fish Oil, The Right Fat Ratios In Your Diet, Plant Vs. Animal Based Oils & The Exact Fish Oil Ben Greenfield Uses Every Day.", I've been getting plenty of questions about fish oil lately, including:

-Based on human clinical research, what are the actual proven benefits of fish oil?

-What kind of dosages/types of fish oil were used in studies?

-Are there concerns about rancidity/oxidation when taking fish oil?

-What kind of amount and EPA/DHA ratio is ideal?

-Are there people who shouldn't take fish oil?

-Are there certain nutrients or supplements that should be taken with fish oil?

-How can one test their omega fatty acid status?

And much more.

So I finally decided to get a couple of true, unbiased fish oil experts on my show.

Dr. William S. Harris is my first guest. He is an internationally recognized expert on omega-3 fatty acids and how they can benefit patients with heart disease. He obtained his Ph.D. in Human Nutrition from the University of Minnesota and did post-doctoral fellowships in Clinical Nutrition and Lipid Metabolism with Dr. Bill Connor at the Oregon Health Sciences University.

His interest in omega-3 fatty acids began with his postdoctoral work when he published his first study on the effects of salmon oil on serum lipids in humans (1980). Since that time he has been the recipient of five NIH grants for studies on the effects of omega-3 fatty acids (EPA and DHA) on human health. He has more than 300 publications relating to fatty acids, including omega-3s, in medical literature and was an author on two American Heart Association scientific statements on fatty acids: “Fish Consumption, Fish Oil, Omega-3 Fatty Acids and Cardiovascular Disease” (2002), and “Omega-6 Fatty Acids and Risk for Cardiovascular Disease” (2009) both published in the journal Circulation. Dr. Harris is a Professor in the Department of Medicine in the Sanford School of Medicine at the University of South Dakota and the President and CEO of OmegaQuant.

Dr. Harris's daughter, Dr. Kristina Harris Jackson, PhD, RD is my second guest. Kristina received her PhD in Nutritional Sciences from Pennsylvania State University in 2013 and completed her training to become a Registered Dietitian in 2014. As a graduate student, she studied under Dr. Penny Kris-Etherton, an internationally-recognized expert in fats and nutrition. She worked as a postdoctoral fellow at the University of Colorado-Denver under Dr. John Peters in the area of worksite wellness before returning to the omega-3 field. Kristina joined the family business OmegaQuant Analytics as a Research Associate in 2014, with a particular focus on omega-3s in maternal health, helping create the Prenatal DHA test and the Mother’s Milk DHA test. In 2020, she became Assistant Professor (non-tenure) in the Department of Internal Medicine at the University of South Dakota Sanford School of Medicine. (2020-2022). She lives in Sioux Falls, South Dakota with her husband, two kids, one old dog, and four grandparents.

During this discussion, you'll discover: -The 2 sources of Omega-3 fatty acids...8:35
  1. Plant derived fatty acid ALA, alpha linolenic acid( 18 carbons); an acid in the omega-3 family – not the same thing as the fish derived omega-3
  2. Fish derived EPA (20 carbons) and DHA (22 carbons)
  • Cannot get much of the good stuff from ALA (seeds and nuts)
  • Algal oil from micro algae (single cell organism, not kelp) that make EPA/DHA naturally; at the base of the marine food chain
    • Omega-3 fatty acids are made by plants, not fish
  • Some companies grow these algae in big ponds, harvest the omega-3 fatty acids and put in capsules
    • Vegan derived EPA/DHA products has exactly the same molecules as EPA/DHA derived from fish, but does not come from fish, it comes from algae
    • Process is expensive
  • Aquaculture industry is driving the demand for algal oil
    • 70~80% of fish oil produced is fed back to the fish
  • Other sources of fish oil are genetically modified land plants
    • Canela seed oil; Australia is at the forefront to put genes into oil producing land plants, like soy beans
-What makes essential fatty acids so essential...15:45
  • Cell membranes, made up of fatty acids, surround every cell in the body
    • For structural aspect of the cell
    • Provides starting products for different signaling pathways, affects how cells communicate internally and externally
    • Membrane fluidity; more carbon and double bonds makes cell membranes more flexible and fluid
  • Cell membranes are comprised of dietary fats
    • The body can’t make the essential omega-6 fatty acids (linoleic) and omega-3 fatty acids(ALA and EPA/DHA); these comes from the diet
    • Trans-fats are also dietary fats
  • Other fats, like saturated fats and monounsaturated fats, are affected by metabolism
-Omega-3 fatty acids being oxidized once it enters the body is a misconception...19:36 -Ratio of omega fatty-acids in the body and what the ratios should be...25:32
  • Good ratio of EPA to DHA is when eaten in fish
    • EPA taken alone increases EPA and decreases DHA a little bit; increased omega-3 index - the measure of EPA/DHA in red blood cells (RBC)
    • Pure DHA taken alone increases both EPA and DHA in RBC
    • DHA is the predominant omega-3 fatty acid in membranes
    • 85% DHA to 15% EPA in RBC
    • In fish oil, total dose (EPA+DHA) is the important thing
    • A study found the ideal optimum fatty acid levels (EPA+DHA) to be 8~12% index
  • Ratio of omega-6 to omega-3
-Ethyl Ester and Triglyceride forms of Omega-3 fatty acids...33:20
  • Different ways Omega-3 fatty acids are processed and concentrated
    • Ethyl ester is the first highly concentrated form; first to be concentrated into a capsule
    • Triglycerides form is the more natural form (how it would be present in the fish)
  • Most fish oil supplements in the U.S., if it does not say it is in triglyceride form, is an ethyl ester
  • No standardized way to know if it is triglycerides or ethyl ester
  • Biggest difference as far as bioavailability goes is if supplements are taken with meals
    • Ethyl esters, if taken without a meal might not be absorbed at all; absorbed well if taken with a meal, preferably a meal that contains fats
    • Triglycerides are not affected by that meal component as ethyl esters
  • All pharmaceutical brands of fish oil are ethyl esters
    • More EPA and DHA molecules in a 1 gram capsule if in ethyl ester form
  • Distinction only came up around 15 years ago when ethyl ester form of fatty acids was seen as not well absorbed by the body when taken on an empty stomach
    • Taking ethyl ester form supplements without food might not get the desired omega-3 index result
-What genes convert ALA or plant-based oil into EPA/DHA...45:15
  • Genetic conditions that affect omega-3 fatty acid levels
    • FADS genes produce the enzymes that convert ALA to EPA and DHA
    • Enzymes also convert linoleic acid to arachidonic acid (polyunsaturated omega-6 fatty acid)
  • Natural variations by populations in the kinds of mutations that are present in the FADS genes can affect levels, particularly of arachidonic acid
  • Omega-3 EPA/DHA are not much affected by the FADS genes
  • Major genetic effect driving omega-3 levels in the population is not known
  • Is there a genetic effect on the absorption of omega-3 in the population?
    • No study on why a certain population has a huge absorption response while in another population, there is hardly any response
  • Nomenclature:
    • Omega-3 ­– a fatty acid where the 1ˢᵗ double bond counting from the omega carbon is in the third position
    • Omega-6 – a fatty acid where the 1ˢᵗ double bond counting from the omega carbon is in the sixth position
  • Cannot be inter-converted
  • Plants can convert omega-6’s into omega-3’s, animals cannot
-Ratio of omega-6 to omega-3 fatty acids...52:17
  • “Ratio of omega-6 to omega-3” is imprecise – it’s not clear what type omega-6 or omega-3 is referred to; for example, there are 7 omega-6 fatty acids in the blood
    • It also presumes that ALA and EPA/DHA have the same biologic activity or they have the same value when they do not
    • The same is also true on the omega-6 side
  • To say “total omega-6 to total omega-3 ratio” would also be confusing; it does not say what type fatty acids are there; it does not tell anything about it's effect on health - some fatty acids are beneficial and some are not
  • You can have very high levels of omega-6 and omega-3 in your blood, or you can have very low levels, and yet have the same ratio
  • It also presumes that all omega-6’s are bad and all omega-3’s are good, which is not true
    • Omega-3 fatty acids being good is not questionable
    • What’s questionable is the goodness or badness of omega-6’s; linoleic acid is not made in the body and has to be eaten
    • Studies have shown that high levels of linoleic acid in the blood always predict lower incidence of heart disease and diabetes, and conversely
  • Focus on the omega-3 index is that EPA/DHA are what is missing in our diets; there are plenty of omega-6’s
-Link between Omega-6 and inflammation and chronic disease...1:00:18
  • High consumption of oxidized PUFAs , primarily found in vegetable oils which are high in omega-6 fatty acids
  • Omega-6 fatty acid that gives rise to eicosanoids in the inflammatory pathway is Arachidonic acid, a synthetic product of linoleic acid
  • Eicosanoids is associated with increased incidence of inflammation and chronic diseases like arthritis, cancer, etc.
  • Synthesis of arachidonic acid is very regulated; tissue levels remain the same regardless the amount of linoleic acid consumed, to a point (it eventually runs out if linoleic acid consumption is stopped)
  • Higher levels of linoleic acid in the blood means you are eating more of it, which comes from vegetable oil; the only way to get high levels in your blood is to eat more
  • For heart disease and diabetes, higher levels of linoleic acid is good for the heart and metabolism; less people develop these diseases if they have high levels of linoleic acid
  • The best way to decrease the ratio is to increase your omega-3 side; by increasing EPA/DHA, EPA replaces, to some extent, the arachidonic acid
    • Having more long-chain omega-3 in the membranes lowers omega-6, correcting the proportion
-Contaminants in fish oil, cleanliness, sourcing, concerns about packaging, shelf life, heat exposure during the manufacturing process...1:06:13 -And much more! Resources from this episode:

-OmegaQuant

-Kion Omega (use code BGF20 to save 20%)

-Articles:

Episode sponsors:

-Kion Omega: If you're ready to upgrade your fish oil, head over to getkion.com and grab Kion Omega. Use code BGF20 to save 20% off your first order.

-Organifi Red Juice: Enjoy all the benefits of the 11 superfoods and their micronutrients that help increase resting metabolism, support cardiovascular health, and remove toxins to turn back the hands of time! Receive a 20% discount on your entire order when you use discount code BENG20.

-Four Sigmatic: I’ve been using Four Sigmatic products for awhile now and I’m impressed by the efficacies of their mushroom products. I use them. I like them. I support the mission! Receive 15% off your Four Sigmatic purchase when you use discount code BENGREENFIELD.

-Thrive Market: Organic brands you love, for less. Your favorite organic food and products. Fast and free shipping to your doorstep. Receive a gift card worth up to $20 when you begin a new membership.

Do you have questions, thoughts or feedback for Dr. Harris or me? Leave your comments below and one of us will reply!

See omnystudio.com/listener for privacy information.

Avsnitt(1746)

Vaccines?! Between a Shot & a Hard Place: Are Childhood Vaccines SAFE, How Many Do Kids Really Need & What Parents Should Ask, with Dr. Joel Warsh

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Is This Like Drinking HUNDREDS of Bottles Of Hydrogen In A Single Sitting? The Massive Antioxidant Benefits of *Inhaling* Hydrogen, With Dr. Tyler LeBaron & Alex Tarnava.

Is This Like Drinking HUNDREDS of Bottles Of Hydrogen In A Single Sitting? The Massive Antioxidant Benefits of *Inhaling* Hydrogen, With Dr. Tyler LeBaron & Alex Tarnava.

Tyler W. LeBaron, MSc, Ph.D., is the founder and executive director of the nonprofit Molecular Hydrogen Institute. With a background in biochemistry, physiology, and exercise science, he teaches exercise physiology and chemistry labs at Southern Utah University as an adjunct instructor. He interned at Nagoya University in Japan's Department of Neurogenetics, researching the molecular mechanisms of hydrogen gas on cell-signaling pathways. Tyler is a director of both the International Hydrogen Standards Association (IHSA) and the International Molecular Hydrogen Association (IMHA). He speaks at medical and academic conferences worldwide, collaborates with researchers globally, and works to advance the education and awareness of hydrogen as a therapeutic medical gas. Outside the lab, he trains in running and competes in arm wrestling. Alex Tarnava is a self-taught scientist, inventor, and author whose work bridges biomedical innovation, sovereign health, and philosophical disruption. He invented the world’s only open-cup molecular hydrogen tablet—a patented delivery system that has become the most studied and widely adopted form of hydrogen therapy, featured in over 21 published clinical trials. Alex has co-authored 17 peer-reviewed papers, with more in press and under review. He is also the co-inventor—alongside Tyler—of Inhale H₂, the first safe and effective hydrogen inhalation system. His leadership in the field led the Molecular Hydrogen Institute (MHI) to appoint him as the first chairman of its Research Committee. Full show notes: bengreenfieldlife.com/inhalehydrogen Episode Sponsors: LeelaQ: Not only do LeelaQ’s products neutralize EMFs, increase ATP production, optimize HRV, and improve blood flow, but they've been third-party proven to do so in placebo-controlled double-blind studies. Visit leelaq.com and use code BEN10 for 10% off. Gameday Men’s Health: Gameday Men's Health offers science-backed, physician-led men's health optimization with personalized protocols for testosterone, peptide therapy, ED treatment, and more—helping you perform at your best whether you're training hard or keeping up with life. Visit gamedaymenshealth.com/bengreenfield for a free testosterone test and consultation at a clinic near you. BEAM Minerals: If you want to up your mineral game, give BEAM Minerals a try. Go to beamminerals.com and use code BEN at checkout for 20% off your order. Thrive Market: Discover how Thrive Market delivers premium, clean-label groceries from top brands like Simple Mills and Primal Kitchen at up to 30% off retail prices, making healthy eating accessible without compromising your budget or values. Skip the junk without overspending—visit thrivemarket.com/ben for 30% off your first order plus a FREE $60 gift. BiOptimizers MassZymes: MassZymes is a powerful best-in-class enzyme supplement that improves digestion, reduces gas and bloating, and provides relief from constipation. Go to bioptimizers.com/ben and use code ben10 for 10% off your order. BON CHARGE: BON CHARGE is a holistic wellness brand with a wide range of products that naturally address the issues of modern life. Their products can help you sleep better, perform better, recover faster, balance hormones, reduce inflammation, and so much more. Go to boncharge.com/GREENFIELD and use coupon code GREENFIELD to save 15%.See omnystudio.com/listener for privacy information.

13 Sep 20251h

Low-Carb Vs. High-Carb Battle — What's BETTER For Your Health & Metabolism: Fats or Sugar? with Dr. Eric Westman and Jay Feldman

Low-Carb Vs. High-Carb Battle — What's BETTER For Your Health & Metabolism: Fats or Sugar? with Dr. Eric Westman and Jay Feldman

Jay Feldman is a health coach, independent health researcher, and the host of The Energy Balance Podcast. With degrees in neuroscience and exercise physiology from the University of Miami, he chose not to pursue medical school after realizing conventional medicine often fails to address the root causes of common health issues. After exploring both conventional and alternative paradigms and experimenting with diets from vegetarian to keto, Jay discovered that cellular energy is the foundation of health. He now uses a bioenergetic approach to help people worldwide overcome symptoms of low energy, including chronic hunger, poor sleep, and stubborn weight gain. Dr. Eric Westman is an Associate Professor of Medicine at Duke University. He is board-certified in Obesity Medicine and Internal Medicine, and founded the Duke Keto Medicine Clinic with Dr. William S. Yancy Jr. in 2006 after 8 years of clinical research regarding low-carbohydrate ketogenic diets. A past president and master fellow of the Obesity Medicine Association and fellow of The Obesity Society, Dr. Westman co-authored The New Atkins for a New You, Cholesterol Clarity, and Keto Clarity, and co-founded Adapt Your Life, a low-carb education and product company. Full show notes: bengreenfieldlife.com/lowhighcarb Episode Sponsors: Hiya: Give your kids the full-body nourishment they need to grow into healthy adults. I’ve secured a special deal with Hiya on their best-selling children's vitamin—get 50% off your first order today! To claim this deal, you must go to hiyahealth.com/BEN (it is not available on their regular website). Health Lighting: If you want to see and feel the difference better light can make in your life, give Chromalux® full spectrum light bulbs a try. Go to healthlighting.com and use code Ben10 at checkout to save 10% off your order. Organifi: Get the restful sleep you need with the most soothing ingredients! Organifi is a delicious superfood tea with powerful superfoods and mushrooms to help you sleep and recover so you can wake up refreshed and energized. Go to Organifi.com/Ben for 20% off your order. Prolon: Prolon's 5-Day Fasting Nutrition Program is scientifically tested and patented to nourish your body while keeping it in a physiological fasted state. Right now, you can save 15% on your 5-day nutrition program when you go to prolonlife.com/GREENFIELD. Pique: Pique Teas is where plants and science intersect to produce teas and supplements of unrivaled efficacy, purity, and convenience. Go to Piquelife.com/Ben to get 20% off for life, plus a free starter kit with a rechargeable frother and glass beaker to elevate your ritual. Seatopia: Seatopia delivers lab-tested, sushi-grade seafood that’s verified to be mercury-safe and free from detectable microplastics. Frozen at peak freshness, you'll receive the benefits of super nutrients like EPA, DHA, selenium, zinc, and vitamin D. Right now, you can save 15% on your first box and get a FREE 1:1 chef-led cooking class to kick-start your journey to cooking gourmet seafood at home by going to seatopia.fish/ben or by using code BEN at checkout.See omnystudio.com/listener for privacy information.

11 Sep 20251h 6min

Could This “Bible Secret” Be The Cure For Cancer? The WISEST Meal In The World, Pork & Shellfish *Confusion* & Much More With Jordan Rubin

Could This “Bible Secret” Be The Cure For Cancer? The WISEST Meal In The World, Pork & Shellfish *Confusion* & Much More With Jordan Rubin

In this episode with repeat guest Jordan Rubin, you’ll uncover a holistic plan for building strength, health, and longevity from one of the world’s most recognized natural health experts. Jordan shares how his family tradition of reciting Psalm 91 and insights from his new book, The Biblio Diet, reveal timeless biblical wisdom for vibrant living. He also highlights his groundbreaking research on “healing leaves” from fruit trees—their potential to fight cancer, balance blood sugar, reduce inflammation, and support longevity—and how to turn them into a daily healing tea. Jordan Rubin is the founder of Garden of Life, Beyond Organic, and Ancient Nutrition, and the New York Times bestselling author of The Maker’s Diet and over 30 other titles, including The Biblio Diet. An eco-entrepreneur and global lecturer, he has shared his message of natural health worldwide, formulated nearly 1,000 bestselling supplements and functional foods, and operates Regenerative Organic Certified farms in Missouri and Tennessee. Full show notes: https://bengreenfieldlife.com/biblio Episode Sponsors: MASA Chips: Introducing the best guilt-free snack on the market: classic, seed oil free tortilla chips with only 3 natural ingredients. Go to masachips.com/greenfield and get 25% off your first order! Quantum Upgrade: Recent research has revealed that the Quantum Upgrade was able to increase ATP production by a jaw-dropping 20–25% in human cells. Unlock a 15-day free trial with the code BEN15 at quantumupgrade.io. Ketone-IQ: Ketone-IQ delivers science-backed performance fuel that increases power output by 19%, reduces fatigue by 10%, and naturally boosts EPO production for better oxygen delivery—trusted by elite athletes like Jon Jones and Olympic champions. Save 30% on your subscription plus get a free gift with your second shipment at Ketone.com/BENG. Fatty15: Fatty15 is on a mission to optimize your C15:0 levels and help you live healthier, longer. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/BEN and using code BEN at checkout. LVLUP Health: I trust and recommend LVLUP Health for your peptide needs as they third-party test every single batch of their peptides to ensure you’re getting exactly what you pay for and the results you’re after! Head over to lvluphealth.com/BGL and use code BEN15 for a special discount on their game-changing range of products. ZBiotics Pre-Alcohol Probiotic: The world's first genetically engineered probiotic that helps break down the toxic byproduct of alcohol, Zbiotics Pre-Alcohol allows you to enjoy your night out and feel great the next day. Order with the confidence of a 100% money-back guarantee and 15% off your first order at zbiotics.com/BEN15.See omnystudio.com/listener for privacy information.

6 Sep 20251h 6min

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