The Truth About Ketamine: Depression Cure, Health Fad, or Placebo?

The Truth About Ketamine: Depression Cure, Health Fad, or Placebo?

One week ago, Matthew Perry’s autopsy report came back, finding that the ‘Friends’ actor died from the acute effects of ketamine overdose. His death has sharpened focus on the popular and controversial drug. Ketamine has been hailed as a miracle cure for depression and anxiety, criticized as a VC-fueled fad, and investigated as a placebo. But what is ketamine, what is its history, what do we know about how and why it works, and how could it help hundreds of millions of people with depression and anxiety? Today’s guest is Boris Heifets. He is an assistant professor of anesthesiology at Stanford University and the author of a much talked about and utterly fascinating study on ketamine that came up with a brilliant way to test the effects of ketamine. The study's surprising results raise big questions about not only ketamine, but the curative power of belief. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Boris Heifets Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

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How America Became a Nation of "Free Speech Hypocrites"

How America Became a Nation of "Free Speech Hypocrites"

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30 Sep 202552min

What’s the Matter With America’s Food?

What’s the Matter With America’s Food?

In the past few weeks, we’ve done several episodes on obesity, GLP-1 drugs, and nutrition science. What we haven’t talked about as much is the politics of food. And today’s guests say: If you really ...

26 Sep 202552min

This Is How the AI Bubble Could Burst

This Is How the AI Bubble Could Burst

This year, American tech companies will spend $300 billion to $400 billion on artificial intelligence, which is in nominal dollars more than any group of companies have ever spent to do anything. Nota...

23 Sep 202559min

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Matt Belloni, the host of the Town podcast and the author of Puck’s 'What I’m Hearing' newsletter, joins the show to talk about Jimmy Kimmel's punishment, what happened behind the scenes at ABC and Di...

19 Sep 202540min

If GLP-1 Drugs Are Good for Everything, Should We All Be on Them?

If GLP-1 Drugs Are Good for Everything, Should We All Be on Them?

To read more of Derek's reporting on GLP-1 drugs, you can subscribe to his Substack here. GLP-1 drugs like Ozempic and Zepbound don't just help with Type 2 diabetes and weight loss. They seem to curb...

16 Sep 202554min

Charlie Kirk's Killing and America's Age of "Salad-Bar Extremism"

Charlie Kirk's Killing and America's Age of "Salad-Bar Extremism"

In the past few years, we have witnessed a frightening spiral of political violence. We’ve seen the killing of Charlie Kirk; the killing of Brian Thompson, the health insurance executive; the assassin...

12 Sep 202552min

America in the Age of Diagnosis

America in the Age of Diagnosis

America is sicker than ever. That’s what the data says, anyway. Psychological and psychiatric diagnoses have soared. Between the 1990s and the mid-2000s, bipolar disorder among American youth grew by...

9 Sep 202557min

Trumponomics Explained, Part 2: The Enshittification of American Power

Trumponomics Explained, Part 2: The Enshittification of American Power

In the second of our two-episode series on Donald Trump, economics, and power, we talk to Henry Farrell, a professor of political science at Johns Hopkins. Farrell has written extensively on how the U...

5 Sep 202552min

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