#478 Mitochondria Scientist: The Only Proven Way to Extend Human Lifespan - Dr Mark Tarnopolsky
Dr. Mark Tarnopolsky is a Professor and Division Head of Neuromuscular and Neurometabolic Disorders in the Department of Pediatrics at McMaster University. He completed a PhD in Cell Biology and Metabolism in 2001.Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:25 What are mitochondria03:55 Mitochondria in aging and longevity06:00 Oxidative stress, inflammation, and longevity09:30 Antioxidants and benefits of exercise12:40 Bon Charge sponsorship13:30 Who should take antioxidants21:30 Mark’s antioxidant cocktail study24:30 Why is exercise the best thing for your mitochondria30:35 How endurance training shapes the mitochondria35:10 High intensity interval training36:50 Role of mitochondria in muscle loss42:00 Nutrition for mitochondrial health46:50 Supplements for mitochondrial health53:35 Stimulating mitophagy Dr Mark Tarnopolsky research page: https://scholar.google.com/citations?user=4jhi_KkAAAAJ&hl=en
8 Nov 202559min
#477 The Science of Longevity Genes: What We’ve Learned from Centenarians - Dr Tyler Panzner
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:48 The genetics of a 117-year-old woman08:16 Resilience, immunity and longevity14:33 Muscle building genetics19:33 FOXO3 and stress resilience24:53 FOXO3 gene editing32:08 Can telomere lengthening be harmful to some individuals38:58 IGF-1 and growth hormone and longevity50:08 Genetically short sleepers54:38 What you should know about your longevity genesFirst podcast with Tyler about genetics and supplements: https://youtu.be/9GLbTEYewUsTyler Panzner channel: https://www.youtube.com/@drtylerpanzner
31 Okt 20251h
#476 Siim Land on Human Immortality, Gene Editing, Biomarkers - The Beyond Tomorrow Podcast
Timestamps0:00 – Introduction4:12 – Humans adapt, and that changes the rules9:58 – Diet diversity, sensitivities, and n of 116:51 – Assess first: biomarkers that predict disease risk18:27 – Fixing sleep, movement, diet, environment22:47 – Caution on rapamycin, metformin, methylene blue25:54 – FOXO3 stem-cell study and what it means37:15 – Mindset and willpower as real enhancers41:44 – TMG, astaxanthin, melatonin, creatine47:09 – VO2 max priorities and performance trade-offs48:51 – Balancing fitness with joy and purpose53:18 – Biomarkers mediate risk more than labels1:01:00 – 2030–2040: what is realistic1:04:02 – Immortality probabilities and living well nowJulian Issa video podcast: https://youtu.be/vV8yMVGLG6Y?si=XiLxOx0bSSM-xT-v
24 Okt 20251h 6min
#475 Q&A: Biggest things that contribute to my health, does caffeine age the brain, can you make up for lost sleep and more
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Does exercise increase inflammation03:03 Melatonin megadosing research04:23 NOVOS vs Blueprint VS DoNotAge07:44 Hidden things that contribute to my health12:14 Bon Charge sponsorship13:05 How to improve night shift work15:40 Supplements to take before the sauna17:15 Does caffeine age the brain19:34 Can you make up for lost sleep20:40 Thoughts on Urolithin A23:14 Doing too much for longevity27:59 How to stop waking up at 3AM30:57 How much sodium do I consume33:20 Do sleep supplements blunt natural sleep37:07 Inflammation in longevity41:23 Importance of good relationship with food
18 Okt 202547min
#474 Longevity Supplements Ranked From Best to Worst
Get my 2025 supplement guide: https://www.siimland.co/supplement-list-2025Timestamps:00:00 Intro00:14 Taurine01:19 Apigenin01:55 Resveratrol03:20 Rapamycin04:55 Metformin06:11 Calcium AKG07:30 Melatonin08:16 SIRT609:05 NAC09:43 NMN, NR, Niacinamide11:10 Niacin13:58 Glycine15:16 Spermidine16:44 Omega-3s17:40 Creatine18:48 Pterostilbene19:19 Magnesium20:16 Vitamin K220:45 Sulforaphane21:34 Curcumin22:08 Methylated B vitamins22:33 Glutathione24:08 Lithium24:55 Lutein & Zeaxanthin25:30 Vitamin C26:29 Ergothioneine27:23 Methylene blue28:46 Multivitamin29:37 Aged garlic extract30:22 Astaxanthin31:06 TMG31:50 Ginger32:15 CoQ1032:53 PQQ33:24 Chondroitin33:45 MSM32:25 Glucosamine34:54 Conclusion100 supplements ranked worst to best: https://youtu.be/W8DZbYyuDmAJoin our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/
10 Okt 202537min
#473 Tech Expert: Why Life Speeds Up As You Age (And How To Slow It Down!)
Chris Dancy is called 'the most connected man on Earth' because of his pioneering use of technology in everyday life and health optimization.Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:23 Why Chris is the most connected man on earth03:38 How Chris used technology to lose weight and get healthy08:43 How technology changes the human experience in the future10:43 Best tools 16:28 The technology Renaissance period20:43 Bon Charge sponsorship21:38 Implants24:18 Hacking time33:28 Meditation and mindfulness36:48 Does time go by faster if you’re stuck in daily routines47:38 How Chris’ perception of time has changed as he got older52:43 Will virtual reality extend perception of lifespan59:03 How to make technology better for your healthChris Dancy website: https://www.chrisdancy.com/
4 Okt 20251h 2min
#472 Scientist Reveals the Hidden Program of Aging and How to Control It - Josh Mitteldorf PhD
Josh Witteldorf is a PhD in physics who pivoted to researching aging and investigated the evolutionary reasons for aging and human lifespan. He's written the book Cracking the Aging Code.Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:30 How Josh, as a physicist, got into aging research04:35 Why aging is an evolutionary program13:50 Why humans die and age20:45 Bon Charge sponsorship21:35 Why did aging evolve as an adaptation24:40 Species that are biologically immortal30:25 Shocking way group selection selects for aging and death33:55 How predator-prey relations select for aging43:15 Can humans control our own evolution48:15 A long-term human calorie restriction experiment in Biosphere 252:50 Insulin’s effects on aging 55:20 mTOR and aging57:15 Can you deprogram aging and extend lifespan01:10:00 Gene editing01:15:15 Josh’s predictions for the futureJosh Mitteldorf blog: https://scienceblog.com/joshmitteldorf/ Josh's book Cracking the Aging Code: https://amzn.to/4mFmC6mStart rewinding your biological clock: https://www.siimland.co/course
26 Sep 20251h 20min
#471 Ranking 100 Health Biomarkers (Most to Least Important)
Get my free bloodwork cheat sheet: https://www.siimland.co/bloodwork-cheat-sheetTimestamps:00:00 Intro00:32 Resting heart rate02:27 hsCRP03:32 VLDL03:52 LDL particle count04:31 Homocysteine 05:26 Respiratory rate06:30 VO2 max07:36 Body fat percentage09:18 BMI11:57 HRV14:14 Waist circumference and waist to hip ratio16:00 Visceral fat mass and liver fat18:42 White blood cells20:35 Albumin21:11 Muscle mass22:40 Grip strength24:15 Appendicular lean mass index25:31 Creatinine27:55 eGFR29:20 Cystatin C29:32 Biological age tests31:45 Speed of aging test32:45 Phenoage34:25 Bone density36:00 Lung force36:59 Lp(a)38:15 Oxidized LDL39:00 Testosterone43:40 SHBG45:22 Estradiol (E2)46:42 Resting metabolic rate49:00 Body temperature51:48 Liver enzymes (ALT, AST, GGT, ALP)53:14 ApoB55:10 IGF-157:30 ApoA59:30 Calcium score in the arteries (CAC)01:00:46 Carotid intima media thickness (CIMT)01:03:18 Iodine01:05:09 Thyroid hormones (T3 and T4)01:08:00 Progesterone and pregnenolone01:08:51 Thyroid-stimulating hormone (TSH)01:09:47 BNP (cardiac stress)01:10:22 Hemoglobin01:11:22 Iron and ferritin01:12:56 Uric acid01:13:49 HDL cholesterol01:14:53 HbA1c01:15:39 Fasting insulin01:15:58 Fasting glucose01:17:23 Fructosamine01:18:11 Triglycerides01:19:07 Omega-3 index01:20:26 Omega-6-to-3 ratio01:21:01 Red cell distribution width (RDW)01:21:22 Platelets01:22:22 Mean corpuscular volume (MCV)01:22:39 LDL cholesterol01:23:18 Mean corpuscular hemoglobin (MCH)01:23:33 Blood urea nitrogen (BUN)01:23:57 DHEA-S01:24:52 Vitamin D01:26:07 HOMA-IR01:26:26 Red blood cells01:26:38 Hematocrit01:27:01 Erythrocyte sedimentation rate (ESR)01:27:38 LP-PLA201:28:15 Electrolytes01:29:09 Total cholesterol01:29:23 B vitamins01:30:29 Total iron binding capacity (TIBC) and transferrin saturation01:31:00 Heavy metals01:32:48 Microplastics01:34:54 Cortisol01:36:10 TNF-alpha01:36:50 How much can you lift?01:39:22 Cooper test01:40:25 Microbiome diversity01:42:08 Conclusion100 supplements ranked worst to best: https://youtu.be/W8DZbYyuDmA
20 Sep 20251h 43min
