#223 Anti-Aging Gene Therapy - Liz Parish

#223 Anti-Aging Gene Therapy - Liz Parish

Welcome to the Siim Land Podcast I’m your host Siim Land and our guest today is Liz Parish. Liz is the founder and CEO of BioViva. Which is a company committed to extending human lifespan using techniques such as gene and cell technologies. Liz Parrish became the first person worldwide to take dual gene therapies for treating aging. This episode is brought to you by BiOptimizers Magnesium Breakthrough. Magnesium is one of the most important minerals in your body and it’s involved in hundreds of processes, starting with energy production and ending with cognition. Magnesium deficiency increases the risk of insulin resistance and cardiovascular disease. What’s worse, up to 70-80% of people are not getting enough magnesium because our food contains about 25% magnesium than a few decades ago. I think magnesium is one of the few nutrients almost everyone would need more of. That’s why I use Magnesium Breakthrough that contains 7 of the main magnesium types. It’s the most full spectrum magnesium supplement out there. Head over to the show notes of this episode at siimland.com/223 to get a link for a 10% discount off Magnesium Breakthrough. That’s siimland.com/223 Timestamps: 02:00 What Is Gene Therapy 06:20 Gene Based Technologies 07:50 How Does Gene Therapy Work 10:50 Chronic Diseases and Aging 14:25 Hallmarks of Aging 18:00 Current Advances in Gene Therapy 20:44 Who Would Get Access to Anti-Aging Technologies 26:10 When Will Humans Live Longer 27:55 Can You Still Live an Unhealthy Lifestyle After Gene Editing 32:25 Myostatin Genes and Muscle Growth 35:38 Cognition and Your Genes 39:22 What Gene Therapies Has Liz Taken And much more Here are the links to the podcast on all platforms Link to the Audio Podcast on iTunes and Stitcher Link to the podcast on Spotify Link to the podcast on CastBox Watch the Biohacking Bootcamp Videos on Patreon This episode is sponsored by BiOptimizers. They're giving the listeners of this podcast an exclusive offer on one of their best-selling products. It's called Magnesium Breakthrough and is the most full-spectrum magnesium supplement out there. Most supplements contain only 1 or 2 forms of magnesium... when in reality there are at least 7 that your body needs and benefits from. Magnesium is the master mineral that governs virtually all physiological processes in the body. With volume discounts combined with our custom 10% coupon code, SIIM10, you can save up to 40% off select packages of Magnesium Breakthrough! That’s an AMAZING value. And I promise that deal is ONLY available on this specific website, Click Here to Support the Show on Patreon! Show Notes BioViva Website BioViva Instagram Stronger by Stress on Amazon Stronger by Stress Audiobook The Immunity Fix on Amazon Get Magnesium Breakthrough for a 10% Discount! Use Code SIIM for 10% Off Self Decode Use Code SIIM for a 10% Discount on the KAATSU Bands Get Your Biomarkers Tested with Lets Get Checked At-Home Tests! Use Code SIIMLAND for a 20% Discount (sponsored)! My New Book Stronger by Stress My NEW BOOK Metabolic Autophagy Metabolic Autophagy Audiobook Metabolic Autophagy Master Class Total Sleep Optimization Video Course Get the FULL GUIDE to INTERMITTENT FASTING FREE BOOK Get the Metabolic Autophagy Program Keto Adaptation Manual Book Watch the Biohacking Bootcamp Videos on Patreon Body Mind Empowerment Handbook Keto Fit Program Keto // IF Program Stay Empowered Siim

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#423 Top Longevity Scientist Predicts Dramatic Life Extension by 2035 - Aubrey de Grey

#423 Top Longevity Scientist Predicts Dramatic Life Extension by 2035 - Aubrey de Grey

Order my new book: https://www.amazon.com/dp/B0CW1B2XM1 Timestamps: 00:00 Introduction 00:37 Twenty since Aubrey coined the Longevity Escape Velocity 11:13 When will we reach Longevity Escape Velocity 16:45 Slowing down aging vs regeneration 19:44 What breakthroughs we need for longevity escape velocity 24:00 Seven types of aging damage that needs to be repaired 24:37 Loss of cells and stem cells 33:57 Regenerating limbs and organs 36:10 Mitochondrial free radical theory of aging 41:15 Intracellular and Extracellular waste products 47:15 How far is gene therapy now? 49:15 Death resistant cells 53:52 Do you need long telomeres 57:15 Extracellular matrix stiffening and glycation 01:00:48 Biggest breakthroughs in the next 5 years 01:04:30 What to do to live until the longevity escape velocity The Longevity Escape Velocity Foundation: https://www.levf.org/ Aubrey de Grey Twitter: https://x.com/aubreydegrey

17 Okt 20241h 8min

#422 Cancer Biologist Shares the Science of Cancer Prevention - Dr Joe Zundell PhD

#422 Cancer Biologist Shares the Science of Cancer Prevention - Dr Joe Zundell PhD

Order my new book: https://www.amazon.com/dp/B0CW1B2XM1 Timestamps: 00:30 Introduction 00:50 What is cancer 04:30 Does everyone have cancer all the time? 06:30 When does cancer become lethal 11:30 Hallmarks of cancer 21:20 Senescent cells vs cancer cells 25:00 Evolutionary purpose of cancer 27:30 Cancer prevention 30:10 Ultra processed food and cancer risk 35:35 Organic vs non-organic food 38:40 What are carcinogens 45:10 Immune function and cancer 48:15 Meat and cancer 51:20 mTOR and cancer 01:02:20 Glucose, Warburg Effect and cancer 01:07:00 Ketones and cancer 01:11:00 Artificial sweeteners 01:16:40 Environmental toxins Dr Joe Zundell YouTube channel: https://www.youtube.com/@dr.joezundell Dr Joe Zundell Instagram: https://www.instagram.com/dr.joezundell/

13 Okt 20241h 26min

#421 Supplements That HARM Your Heart - Q&A

#421 Supplements That HARM Your Heart - Q&A

Use code SIIM for a 15% discount off Bon Charge: https://boncharge.com/pages/siimland Timestamps: 00:01 Supplements that are bad for the heart 08:45 Will we see someone live to 125 11:56 Bon Charge sponsorship 12:46 Maltodextrin in protein powder 13:59 Hyaluronic acid supplementation and cancer 15:32 Creatine reduces VO2 max 17:55 Limiting factor in losing visceral fat 20:45 Which disease am I most afraid of 25:13 Weighted stretching for muscle growth 28:00 Protein restriction and lifespan 32:22 How to train with joint pain 35:39 How much NAC for 60+ 37:23 How to stimulate appetite 40:47 What's a good VO2 max for women Order my new book: https://www.amazon.com/dp/B0CW1B2XM1 Get The Longevity Leap Worksheet: https://www.siimland.co/offers/gX7pV7RF

5 Okt 202443min

#420 The Weird Connection Between Omega 3 and Your Heart Health - Dr William Harris, PhD

#420 The Weird Connection Between Omega 3 and Your Heart Health - Dr William Harris, PhD

Order my new book: https://www.amazon.com/dp/B0CW1B2XM1 Timestamps: 00:37 Omega 3 Health Benefits as of 2024 03:50 Why Are Omega 3 Fats Beneficial 08:57 My New Book The Longevity Leap 09:15 Why Aren't Omega 3s Essential 09:57 What Is the Omega 3 Index 14:45 Is There Risk of Healthy User Bias 17:50 How High Omega 3 Index Is Optimal 26:28 How to Increase Omega 3 Index 29:38 Different Types of Omega 3 Supplements 32:40 Are Omega 3 Supplements Oxidized and Rancid 35:15 How to Choose an Omega 3 Supplement 40:15 Heart Disease and Omega 3s 46:25 Neurodegeneration and Omega 3s 48:00 Omega 6 Fats and Mortality 55:00 How Much Omega 6 Is Too Much 59:48 Omega 9 Fats 01:02:15 How to Store Omega 3 Supplements

28 Sep 20241h 5min

#419 Dave Pascoe and Julie Gibson Clark Discuss Their Diet, Supplements and Exercise Routines

#419 Dave Pascoe and Julie Gibson Clark Discuss Their Diet, Supplements and Exercise Routines

Order my new book: https://www.amazon.com/dp/B0CW1B2XM1 Timestamps: 00:29 Introduction 02:43 Question 1: Death and longevity 11:23 Julie’s advice to Siim 12:58 Meeting likeminded people interested in longevity 17:33 Dave getting stem cells 19:33 Rejuvenation Olympics 22:18 How I share evidence 28:53 Longevity as a sport 40:58 How the Rejuvenation Olympics works 48:28 What’s the best biological age clock 53:58 Telomere length 58:31 How long can we make humans live 01:12:52 Panel about exercise routines 01:19:38 Panel about sleep 01:25:52 Panel about nutrition 01:36:44 Panel about supplements 01:46:44 Best low-hanging fruits Adam the host's channel: https://youtube.com/@nopara73?si=7z6gKAq6s5vZTT_T

22 Sep 20241h 51min

#418 Stem Cell Doctor Shares the Truth About Stem Cell Therapy for Anti-Aging

#418 Stem Cell Doctor Shares the Truth About Stem Cell Therapy for Anti-Aging

Use code SIIM for a 15% discount off Bon Charge: https://boncharge.com/pages/siimland Timestamps: 00:30 Misconceptions about stem cell therapy 04:20 Different types of stem cells 07:10 Bon Charge sponsorship 07:55 Stem cells and aging 09:00 Studies about stem cell anti-aging effects 13:32 FDA regulations regarding stem cells 25:19 How Joy got into stem cells 36:39 Cost of stem cell therapy 43:40 Process of getting umbilical cord stem cells 49:45 Stem cell procedures 57:55 Finding reliable stem cell clinics 01:02:48 Joy Kong's clinic and content Dr Joy Kong YouTube channel: https://www.youtube.com/@JoyKongMD/featured Order my new book: https://www.amazon.com/dp/B0CW1B2XM1

14 Sep 20241h 7min

#417 The Surprising Benefits of Nasal Breathing Nobody Tells You - Leigh Ewin

#417 The Surprising Benefits of Nasal Breathing Nobody Tells You - Leigh Ewin

Code LEAP for 15% off the Longevity Leap Bundle: https://donotage.org/longevity-leap-bundle Timestamps: 00:29 Leigh’s background 06:44 Health benefits of cold exposure and breathwork 09:44 Mammalian dive reflex 11:45 DoNotAge Longevity Leap supplement bundle 13:20 Benefits of breath holds 16:55 How long can you hold your breath for 20:30 Are there benefits to being able to hold your breath for long 25:56 Hyperventilation vs breath holds 34:46 Breathwork exercises for beginners 40:27 How to breathe correctly 45:00 Nasal breathing vs mouth breathing 52:00 How to breathe during exercise 54:45 Leigh’s new book Leigh Ewin's new book: https://www.leighewin.com/leigh-events/p/re-spiritual-awakening-audiobook-pre-order

7 Sep 20241h 1min

#416 Supplements That Damage Kidneys and Liver, mTOR and Longevity, How to Improve Skin Elasticity - Q&A

#416 Supplements That Damage Kidneys and Liver, mTOR and Longevity, How to Improve Skin Elasticity - Q&A

Use code SIIM for a 15% discount off Bon Charge: https://boncharge.com/pages/siimland Timestamps: 00:01 Are Too Many Supplements Bad for Organs 03:46 How to Clear Caffeine From the Body 07:00 When Do I Think Longevity Escape Velocity Will Begin 11:05 Bon Charge Sponsorship 11:49 How to Improve Sleep 14:45 What Biomarker I Want to Improve 19:04 mTOR and Longevity 24:05 How to Increase HRV Besides Exercise 26:25 Do I Have Cheat Meals 27:46 Astaxanthin and Testosterone 29:02 Taking 35 Grams of Glycine Per Day 31:09 Thoughts on Pterostilbene for Longevity 32:25 Essential Supplements for Vegans 34:20 Cancer Prevention 35:42 How to Improve Skin Elasticity 36:43 Does Calorie Restriction Decrease Performance Order my new book: https://www.amazon.com/dp/B0CW1B2XM1 Get The Longevity Leap Worksheet: https://www.siimland.co/offers/gX7pV7RF Join my next retreat at a longevity clinic: https://www.siimland.co/retreat

1 Sep 202440min

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