"Exercise May Be the Single Most Potent Medical Intervention Ever Known"

"Exercise May Be the Single Most Potent Medical Intervention Ever Known"

Exercise is a conundrum. On the one hand, physical activity is clearly one of the best interventions for preventing physical disease and mental suffering. On the other hand, scientists don't really understand how it works inside the body or what exactly running, jumping, lifting, and squatting do to our tissues and organs. That's finally changing. Euan Ashley, a professor of genomics and cardiovascular medicine and the chair of the Stanford Department of Medicine, is a member of a new research consortium that studies rats and humans to understand the molecular changes induced by exercise. Today we talk about the earliest findings from this new consortium, how exercise might have disparate effects in men versus women, why nature’s most effective cardiovascular intervention also seems to be nature’s most effective mental health intervention, as well as whether it will one day be possible to identify the molecular basis of exercise precisely enough to develop exercise pills that give us the benefits of working out without the sweat. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Euan Ashley Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

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America's Tax System Is Broken

America's Tax System Is Broken

If you're a typical worker with a salary, you have almost no control over how much tax you owe. But if you own a company worth billions of dollars, the income tax is, in the words of my guest today, "...

24 Mars 1h 4min

The Casino-ification of America

The Casino-ification of America

In 2017, Americans legally bet about $5 billion on sports. Last year, that number rose to $160 billion. Gambling hasn’t just taken over sports. It’s invaded culture, politics, and even international w...

20 Mars 1h 11min

"Yes, AI Is a Bubble. There Is No Question."

"Yes, AI Is a Bubble. There Is No Question."

The AI buildout continues to break records, as the hyperscalers pour hundreds of billions of dollars into chips and data centers, even as investors punish their stock prices. But the revenue side of t...

17 Mars 1h 9min

The Pill That Works Even When You Know It's Fake

The Pill That Works Even When You Know It's Fake

Why do placebo effects work, even when patients know that they're taking a sugar pill? How do "nocebo" effects work, and why do some people hold onto beliefs that they suspect might bring them pain an...

13 Mars 1h 11min

The Economic Crisis of the Iran War Goes Far Beyond Oil

The Economic Crisis of the Iran War Goes Far Beyond Oil

The Strait of Hormuz is the tiny bottleneck that could destabilize the global economy. As a critical passageway for crude oil, natural gas, and critical inputs for fertilizer, computer chips, and plas...

10 Mars 55min

"American Democracy as We Know It Might Not Survive This Technology"

"American Democracy as We Know It Might Not Survive This Technology"

What happens when the two biggest stories in the world—the Trump White House and the development of advanced artificial intelligence—collide? Well, nothing good, apparently. When contract negotiations...

9 Mars 1h 4min

Trump Is Doubling Down on Iran. How Should Democrats Respond?

Trump Is Doubling Down on Iran. How Should Democrats Respond?

Donald Trump’s polling has continued to edge down week after week. And yet approval of the Democratic Party is still stuck near its all-time low, according to Gallup and other surveys. One interpreta...

6 Mars 42min

The Four Ways That the Iran War Could End

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Dramatic regime change. Moderate regime evolution. A calamitous regional conflict. Or … no change at all. Today we consider how the Iran conflict might evolve following the killing of Supreme Leader K...

3 Mars 55min

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