Reviving Retigabine for Tinnitus - Thanos Tzounopoulos, PhD
Tinnitus Talk24 Maj 2020

Reviving Retigabine for Tinnitus - Thanos Tzounopoulos, PhD

A drug to quieten your tinnitus. It’s what most people struggling with tinnitus desire. We had the pleasure of interviewing Thanos Tzounopoulos, PhD, director of the Pittsburgh Hearing Research Center, on his work to develop just such a drug.

His work builds on the previously somewhat successful off-label tinnitus drug Retigabine. That drug was taken off the market due to severe side effects. Thanos is now attempting to re-develop it, without the side effects, and better targeted at the source of the neural hyperactivity perceived as tinnitus.

In this episode, we speak extensively about Thanos’ theory of how tinnitus is generated in the brain and the role of (broken) potassium channels in this. He explains all the trial and error that went into re-developing the drug and speaks about the upcoming phases of research needed before the drug can come to market.

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Avsnitt(26)

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Tinnitus and Pain, One and the Same? - Prof. Peter McNaughton

Tinnitus and Pain, One and the Same? - Prof. Peter McNaughton

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We revisited with an old friend of the podcast: Dr. Josef Rauschecker. He was our first ever guest – go back and listen to that episode! – who came up with the famous 'gating' theory of tinnitus. Jose...

10 Jan 202434min

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Meet Brian Fargo, a successful video game developer who – when he developed tinnitus – tried every imaginable treatment to get rid of it, to no avail. Frustrated at the lack of effective treatment opt...

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It’s the Data, Stupid! - Christopher Cederroth and David Stockdale

It’s the Data, Stupid! - Christopher Cederroth and David Stockdale

We hear figures of up to 20-30% of the population supposedly having tinnitus, but is tinnitus really that prevalent? In this episode, we learn that such data is based on population studies where peopl...

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