Podcast #296: Synthetic Cannabinoids

Podcast #296: Synthetic Cannabinoids

Author: Rachael Duncan, PharmD

Educational Pearls

  • A NEJM study report in July 2016 discussed a situation in New York during which 30 people became "zombie-like" after ingesting synthetic cannabinoids (aka "Spice).
  • The ER managed to coordinate with the CDC to evaluate blood samples from 18 patients who were transported to the hospital.
  • Of those who went to the ER, the mean age was 36.8, many of them were homeless, all of them were male. Mass spectrometry was used to confirm the presence of synthetic cannabinoid in their blood.
  • Compared to normal THC, synthetic cannabinoids have a much lower EC50 and LD50.
  • Spice intoxication presents in a variety of ways -patients may be hyperthermic, combative, delirious and/or seizing.
  • Treatment is supportive, including fluids, cooling, electrolyte management, and sedatives.

References: Adams, A. J., Banister, S. D., Irizarry, L., Trecki, J., Schwartz, M., & Gerona, R. (2017). "Zombie" Outbreak Caused by the Synthetic Cannabinoid AMB-FUBINACA in New York. New England Journal of Medicine, 376(3), 235-242. doi:10.1056/nejmoa1610300

Avsnitt(1145)

Podcast # 390: Haloperidol for Pain

Podcast # 390: Haloperidol for Pain

Author: Gretchen Hinson, MD Educational Pearls: Reasonable approach of haloperidol 10 mg IM (or 5 mg IV) for pain relief in opioid-dependent patients; can repeat once Chronic opioid use results in ...

10 Okt 20185min

Podcast #389: BRUE

Podcast #389: BRUE

Educational Pearls: BRUE (Brief Resolved Unexplained Event) replaces what was previously called ALTE BRUE describes an event in a child less than one year of age with one or more of the following...

8 Okt 20184min

Podcast #388: Antibiotics for Appendicitis

Podcast #388: Antibiotics for Appendicitis

Author: Aaron Lessen, MD Educational Pearls: 5-year follow up study on antibiotic treatment for uncomplicated appendicitis showed 39.1% recurrence rate requiring appendectomy by 5 years Nearly 6...

5 Okt 20182min

Podcast #387: Fluoroquinolones are Perfectly Safe?

Podcast #387: Fluoroquinolones are Perfectly Safe?

Author: Don Stader, MD Educational Pearls: Fluoroquinolones can cause connective tissue disruption leading not only to tendon rupture but also aortic dissection Retrospective study from Taiwan s...

3 Okt 20183min

Podcast #386: Respecting Transgender Patients

Podcast #386: Respecting Transgender Patients

Author: Kasey Champion, MD Educational Pearls: Transgender populations are frequent victims of discrimination in healthcare Ask transgender patients what their preferred pronoun is It is somet...

1 Okt 20183min

Podcast #385: Probiotics

Podcast #385: Probiotics

Author: John Winkler, MD Educational Pearls: Probiotics are bacteria that are ingested to promote gut health but recent research casts doubt on their effectiveness. Recent study suggests that most...

28 Sep 20182min

Podcast #384: Don't stab a PTA?

Podcast #384: Don't stab a PTA?

Author: Don Stader, MD Educational Pearls: Recent study suggests we may not need to drain uncomplicated peritonsillar abscesses Patients who received medical therapy alone had no difference in c...

26 Sep 20183min

Podcast #383: Prehospital Tubes

Podcast #383: Prehospital Tubes

Author: Sam Killian, MD Educational Pearls: Two high quality randomized control trials published in 2018 demonstrated no difference in mortality or neurologic outcomes when using a supraglottic ai...

24 Sep 20184min

Populärt inom Vetenskap

p3-dystopia
dumma-manniskor
svd-nyhetsartiklar
allt-du-velat-veta
det-morka-psyket
kapitalet-en-podd-om-ekonomi
pojkmottagningen
sexet
rss-ufo-bortom-rimligt-tvivel
rss-vetenskapsradion-2
rss-vetenskapsradion
dumforklarat
halsorevolutionen
rss-broccolipodden-en-podcast-som-inte-handlar-om-broccoli
medicinvetarna
rss-experimentet
bildningspodden
vetenskapsradion
hacka-livet
intergalaktiskt