Podcast #298: Seizures

Podcast #298: Seizures

Author: Sam Killian, M.D.

Educational Pearls

  • The availability of antiepileptic treatment has changed in the last 30 years.
  • A recent study in JAMA followed 18,000 pts with epilepsy for 30 years to assess the effectiveness of looked at seizure control.
  • The study found that although there have been new drugs introduced over the last 30 years, there has not been much of an improvement in seizure control.
  • Side effect profiles and medicine compliance may have improved in this time period, but the main goal of reducing seizure frequency has not been reached.

References: Chen Z, Brodie MJ, Liew D, Kwan P. Treatment Outcomes in Patients with Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic DrugsA 30-Year Longitudinal Cohort Study. JAMA Neurol. Published online December 26, 2017. doi:10.1001/jamaneurol.2017.3949

Avsnitt(1146)

Podcast # 359: Normal EKG

Podcast # 359: Normal EKG

Author: Sam Killian, MD. Educational Pearls: Computer interpretation has a very good negative predictive value of a normal EKG (99%). Of 222 interpreted as "normal," 13 were deemed to have some a...

31 Juli 20184min

Podcast # 358: Affordable ear drop alternatives

Podcast # 358: Affordable ear drop alternatives

Author: Erik Verzemnieks, MD Educational Pearls: Otic (ear) specific antibiotic drops can be expensive Opthalmic (eye) versions are basically identical and can be used as an affordable substitute...

27 Juli 20181min

Podcast #357: Local Anesthetic Toxicity

Podcast #357: Local Anesthetic Toxicity

Author: Michael Hunt, MD Educational Pearls: Toxicity happens from local anesthetics being given too fast, too much, or in the unintended spot Systemic toxicity manifests first with neurologic sy...

25 Juli 20184min

Podcast # 356: Babies can't be born addicted

Podcast # 356: Babies can't be born addicted

Author: Don Stader, MD. Educational Pearls: A baby can be born dependent on opioids but not addicted to them. Opioid addiction (Opioid Use Disorder) is a disease of mature brains and is character...

23 Juli 20184min

Podcast #355: Syphilis

Podcast #355: Syphilis

Author: Aaron Lessen, MD Educational Pearls: Re-emerging STI. Progresses through distinct phases if untreated: Primary syphilis: frequently overlooked because initial chancre is painless. Sec...

20 Juli 20183min

Podcast # 354: Hematometra

Podcast # 354: Hematometra

Author: Sam Killian, MD Educational Pearls: Hematometra: uterus filled with blood due to obstruction of outflow tract. Most commonly a result congenital abnormalities (imperforate hymen, transverse...

18 Juli 20184min

Podcast # 353: Xofluza

Podcast # 353: Xofluza

Author: Sam Killian, MD Educational Pearls: Japan recently approved baloxavir marboxil (Xofluza), which may potentially "kill" Flu A/B within 24 hours Recent RCT trial showed superiority over oselt...

16 Juli 20183min

Podcast #352: TXA for Epistaxis

Podcast #352: TXA for Epistaxis

Podcast #352: TXA for Epistaxis Author: Chris Holmes, M.D. Educational Pearls: TXA: tranexamic acid; used in control of bleeding in major trauma, postpartum hemorrhage, etc. In study of 216 pati...

13 Juli 20183min

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