Podcast #307: Guillain-Barre Syndrome

Podcast #307: Guillain-Barre Syndrome

Author: Peter Bakes, M.D.

Educational Pearls:

  • Rare disease with 1-2 patients out of 100,000. About 60% of patients report a preceding diarrheal illness and classically presents with an ascending motor weakness.
  • Pathophysiology is likely due to molecular mimicry where the immune system creates antibodies against a pathogen (C. jejuni ) which appears similar to the myelin of peripheral nerves resulting in autoimmune demyelination.
  • Diagnosis is made by clinical presentation +/- a spinal tap with a characteristic high protein count but without cells.
  • Treatment is IVIG or plasmapharesis. It is important to monitor respiratory function because about 15% of patients progress to respiratory failure.

References:

Sejvar, James J.; Baughman, Andrew L.; Wise, Matthew; Morgan, Oliver W. (2011). "Population incidence of Guillain–Barré syndrome: a systematic review and meta-analysis"

van den Berg, Bianca; Walgaard, Christa; Drenthen, Judith; Fokke, Christiaan; Jacobs, Bart C.; van Doorn, Pieter A. (15 July 2014). "Guillain–Barré syndrome: pathogenesis, diagnosis, treatment and prognosis". Nature Reviews Neurology. 10 (8): 469–482.

Yuki, Nobuhiro; Hartung, Hans-Peter (14 June 2012). "Guillain–Barré Syndrome". New England Journal of Medicine. 366 (24): 2294–2304.

Avsnitt(1147)

Podcast 611: Flu Season in the time of COVID

Podcast 611: Flu Season in the time of COVID

Contributor: Chris Holmes, MD Educational Pearls: During a typical flu season positive rates of flu tests run around ~20% Surveillance data from Australia, South Africa, and Chile showed remarkably l...

9 Nov 20203min

Podcast 610: Swimmers Itch

Podcast 610: Swimmers Itch

Contributor: John Winkler, MD Educational Pearls: Swimmers itch is due to a flatworm parasitic infection that causes an itchy rash after the worm burrows into the skin The flatworm is passed between ...

3 Nov 20203min

Podcast 609: Kratom

Podcast 609: Kratom

Contributor: Nick Hatch, MD Educational Pearls: Kratom is derived from the evergreen tree sharing the same name, found in Southeast Asia Kratom is legal is most regions Adverse effects of this substa...

2 Nov 20204min

Podcast 608: Another Elevated Lactate?

Podcast 608: Another Elevated Lactate?

Contributor: Jared Scott, MD Educational Pearls: Lactate is a byproduct of anaerobic metabolism or tissue hypoperfusion Though typically associated with severe sepsis, hyperlactatemia can be caused b...

27 Okt 20205min

Podcast 607: Is Pain the Enemy?

Podcast 607: Is Pain the Enemy?

Contributor: Don Stader, MD Educational Pearls: Pain is ubiquitous in the emergency department but it is not the enemy - suffering is Nociception is the ability to feel noxious stimuli which usually ...

26 Okt 20205min

Pediatric Emergencies Brewcast: Common Respiratory Conditions in Pediatric Patients

Pediatric Emergencies Brewcast: Common Respiratory Conditions in Pediatric Patients

Emergency Medical Minute collaborated with CarePoint Health in early March for a night of education on Pediatric Emergencies geared towards mid-level providers at a local Denver brewery for our latest...

21 Okt 202019min

Podcast 606: The Oxygen Wars

Podcast 606: The Oxygen Wars

Contributor: Aaron Lessen, MD Educational Pearls: The use of oxygen is controversial when treating patients with certain conditions, like MI's, stokes, or ARDS because adverse outcomes have been demo...

20 Okt 20203min

Podcast 605: Acute Limb Ischemia

Podcast 605: Acute Limb Ischemia

Contributor: Peter Bakes, MD Educational Pearls: Classically presents with the 6Ps: Pain, pallor, paresthesia, pulseless, poikilothermia (cold), and paralysis Acute limb ischemia occurs by embolic or...

19 Okt 20205min

Populärt inom Vetenskap

p3-dystopia
dumma-manniskor
svd-nyhetsartiklar
allt-du-velat-veta
medicinvetarna
rss-ufo-bortom-rimligt-tvivel
kapitalet-en-podd-om-ekonomi
rss-experimentet
rss-vetenskapsradion-2
sexet
rss-vetenskapsradion
hacka-livet
det-morka-psyket
dumforklarat
rss-spraket
pojkmottagningen
rss-arkeologi-historia-podden-som-graver-i-vart-kulturlandskap
4health-med-anna-sparre
halsorevolutionen
rss-personlighetspodden