Podcast # 341: Tenecteplase vs. Alteplase

Podcast # 341: Tenecteplase vs. Alteplase

Author: Rachel Beham, PharmD

Educational Pearls:

  • Tenecteplase is more specific for fibrin and has a longer half-life than alteplase.
  • In setting of ischemic stroke, tenecteplase before thrombectomy was associated with a statistically higher incidence of reperfusion and better functional outcome than alteplase.

References

Bruce C.V. Campbell B et al (2018). Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke. New England Journal of Medicine. 378:1573-1582

Avsnitt(1147)

Podcast #272: More on Temperature in Sepsis

Podcast #272: More on Temperature in Sepsis

Author: David Rosenberg, M.D. Educational Pearls A study of 20,000 subjects found that reducing fever in sepsis did not improve outcomes such as morbidity, mortality, or length of stay. However, corr...

16 Nov 20172min

Podcast #271: Nexus Chest CT Scan Guidelines

Podcast #271: Nexus Chest CT Scan Guidelines

Author: Chris Holmes, M.D. Educational Pearls The nexus chest CT scan rule is based on an 11,000 subject, multicenter study that looked for signs following a trauma that predicted significant finding...

13 Nov 20173min

Podcast #270: Wound Botulism

Podcast #270: Wound Botulism

Author: Don Stader, M.D. Educational Pearls Wound botulism should be considered in patients with cutaneous lesions and neuromuscular weakness. The toxin produced by clostridium botulinum is the c...

10 Nov 20173min

Podcast #269: Tattoo Ink Complications

Podcast #269: Tattoo Ink Complications

Author: Michael Hunt, M.D. Educational Pearls Tattoo ink is applied below the skin, and because of this, they can lead to keloids, granulomas, tetanus, hepatitis B and C, and skin infections. Tattoo...

8 Nov 20174min

Podcast #268: Poiseuille's Law

Podcast #268: Poiseuille's Law

Author: Dave Rosenberg, M.D. Educational Pearls Poiseuille's Law addresses the flow of a fluid through a tube. Many common ED presentations involve alterations in flow: asthma, MI, ischemic stroke, ...

6 Nov 20176min

Podcast #267: Causes of Very High Lactate

Podcast #267: Causes of Very High Lactate

Author: Dylan Luyten, M.D. Educational Pearls Lactate is a byproduct of anaerobic metabolism, a sign of dying tissue. Dangerous causes of high lactates will not normalize with repeat labs. Crush inju...

3 Nov 20173min

Podcast #266: MI in Young Patients

Podcast #266: MI in Young Patients

Author: John Winkler, M.D. Educational Pearls Some risk factors for MI in the young are history of CAD, stimulant drug use, coronary spasm and diabetes. In those with diffuse ST elevations on EKG, th...

1 Nov 20171min

Podcast #265: The 2017 Flu Vaccine

Podcast #265: The 2017 Flu Vaccine

Author: Rachel Beham, PharmD, Advanced Clinical Pharmacist - Emergency Medicine Educational Pearls CDC recommends using the inactivated, injectable flu vaccine in those 6 months and older. The live a...

30 Okt 20174min

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