Podcast # 470: Zofran and Pregnancy

Podcast # 470: Zofran and Pregnancy

Author: Jared Scott, MD

Educational Pearls:

  • Ondansetron (Zofran) is one of the latest drugs that has had concerns raised about side effects, particularly in pregnancy
  • 2018 study probed two birth defect databases to assess increases in 51 major birth defects with increased exposure to ondansetron
  • Only two of the 51 had even a modest increase, which is unclear in causation (cleft palate and renal agenesis)
  • When administering ondansetron (or any drug) to pregnant women, be able to discuss any potential risks for an informed decision by the patient

Editor's note: in this study, adjusted odds ratios for risk of birth defects from exposure to ondansetron were: cleft palate 1.6 (95% CI 1.1-2.3) and renal agenesis 1.8 (95% CI 1.1-3.0)

References

Parker SE, Van Bennekom C, Anderka M, Mitchell AA. Ondansetron for Treatment of Nausea and Vomiting of Pregnancy and the Risk of Specific Birth Defects. Obstet Gynecol. 2018 Aug;132(2):385-394. doi: 10.1097/AOG.0000000000002679. PubMed PMID: 29995744.

Summarized by Will Dewispelaere, MS3 | Edited by Erik Verzemnieks, MD



Avsnitt(1146)

Podcast #303: Lazarus Effect

Podcast #303: Lazarus Effect

Author: Dylan Luyten, M.D. Educational Pearls The Lazarus phenomenon is the delayed return of spontaneous circulation after cessation of CPR. A prospective study in Finland found 5 out of 840 patient...

9 Mars 20183min

Podcast #302: Flu

Podcast #302: Flu

Author: Jared Scott, M.D. Educational Pearls Flu is widespread throughout the US (through Jan 20th 2018). All age groups have seen surge in hospitalizations, but 65 + age group has seen the largest s...

7 Mars 20183min

Podcast #301: Biliary Pathology

Podcast #301: Biliary Pathology

Author: Don Stader, M.D. Educational Pearls Common pathologies include cholecystitis, choledocholithiasis, and in concerningly ascending cholangitis. Cholecystitis is obstruction at the cystic duct l...

5 Mars 20183min

Opioid Safety Summit: Admiral Winnefeld's Strategy to Wage War on the Opioid Epidemic

Opioid Safety Summit: Admiral Winnefeld's Strategy to Wage War on the Opioid Epidemic

Since the tragic overdose of his son, Admiral Winnefeld has developed an intriguing strategy on how to combat the Opioid Epidemic.

27 Feb 20180s

Dreamland in Denver Part VI: "Dreamland"

Dreamland in Denver Part VI: "Dreamland"

Sam Quinones, American journalist and author of the critically acclaimed book, Dreamland: The True Tale of America's Opiate Epidemic, shares the story of how he discovered the truth about the Opiate E...

16 Feb 201843min

Dreamland in Denver Part V: "Tales from a Harm Reductionist"

Dreamland in Denver Part V: "Tales from a Harm Reductionist"

Lisa Raville, executive director of The Harm Reduction Action Center in Denver, shares tales from her perspective as a Harm Reductionist.

16 Feb 201810min

Dreamland in Denver Part IV: "Doing Harm: Medicine's Role in Creating the Opioid Crisis."

Dreamland in Denver Part IV: "Doing Harm: Medicine's Role in Creating the Opioid Crisis."

Emergency Medical Minute's very own Donald Stader, MD explains Medicine's contribution to the catastrophe that is the Opioid Epidemic.

16 Feb 201819min

Dreamland in Denver Part III:  "Opioid Mythbusters: 10 Fallacies that Fueled the Opiate Crisis"

Dreamland in Denver Part III: "Opioid Mythbusters: 10 Fallacies that Fueled the Opiate Crisis"

Dr. Robert Valuck, director of the Colorado Consortium, presents 10 fallacies that have fueled the Opioid Epidemic.

16 Feb 201819min

Populärt inom Vetenskap

dumma-manniskor
svd-nyhetsartiklar
p3-dystopia
kapitalet-en-podd-om-ekonomi
allt-du-velat-veta
rss-ufo-bortom-rimligt-tvivel
det-morka-psyket
rss-vetenskapsradion
sexet
medicinvetarna
rss-vetenskapsradion-2
rss-experimentet
pojkmottagningen
dumforklarat
hacka-livet
rss-spraket
bildningspodden
rss-broccolipodden-en-podcast-som-inte-handlar-om-broccoli
rss-lara-fran-larda-en-fackbok-och-en-forfattare
intergalaktiskt