Podcast # 470: Zofran and Pregnancy

Podcast # 470: Zofran and Pregnancy

Author: Jared Scott, MD

Educational Pearls:

  • Ondansetron (Zofran) is one of the latest drugs that has had concerns raised about side effects, particularly in pregnancy
  • 2018 study probed two birth defect databases to assess increases in 51 major birth defects with increased exposure to ondansetron
  • Only two of the 51 had even a modest increase, which is unclear in causation (cleft palate and renal agenesis)
  • When administering ondansetron (or any drug) to pregnant women, be able to discuss any potential risks for an informed decision by the patient

Editor's note: in this study, adjusted odds ratios for risk of birth defects from exposure to ondansetron were: cleft palate 1.6 (95% CI 1.1-2.3) and renal agenesis 1.8 (95% CI 1.1-3.0)

References

Parker SE, Van Bennekom C, Anderka M, Mitchell AA. Ondansetron for Treatment of Nausea and Vomiting of Pregnancy and the Risk of Specific Birth Defects. Obstet Gynecol. 2018 Aug;132(2):385-394. doi: 10.1097/AOG.0000000000002679. PubMed PMID: 29995744.

Summarized by Will Dewispelaere, MS3 | Edited by Erik Verzemnieks, MD



Avsnitt(1147)

Podcast # 466: Subacute Sclerosing Panencephalitis

Podcast # 466: Subacute Sclerosing Panencephalitis

Author: Nicholas Hatch, MD Educational Pearls: Measles has a period of infectivity starts before the appearance of the characteristic rash, up to 4-5 days A devastating consequence of measles is Suba...

6 Maj 20193min

Podcast # 465: As easy and 1, 2, 10 - Capillary Refill and Sepsis

Podcast # 465: As easy and 1, 2, 10 - Capillary Refill and Sepsis

Author: Ryan Circh, MD Educational Pearls: The 2019 ANDROMEDA-SHOCK trial compared using serum lactates to capillary refill assessment in septic shock patients to guide resuscitation Capillary refill...

5 Maj 20192min

Podcast # 464: Narcan't?

Podcast # 464: Narcan't?

Author: Aaron Lessen, MD Educational Pearls: A problem of take-home-naloxone is the administration of it by an able-bodied bystander Australian study looked at consecutive opioid overdose deaths in a...

2 Maj 20192min

Podcast # 463: Buproprion Overdose

Podcast # 463: Buproprion Overdose

Author: Erik Verzemnieks, MD Educational Pearls: Buproprion is used as an antidepressant and for smoking cessation Severe buproprion overdoses can cause seizures and lead to cardiac dysrhythmias Benz...

30 Apr 20191min

Podcast # 462: Death after OD

Podcast # 462: Death after OD

Author: Don Stader, MD Educational Pearls: 10% of patients seen in the emergency department for opioid overdose patients will die within a year Half of these overdoses will occur in the next month Th...

27 Apr 20192min

Podcast # 461: Breath Stacking

Podcast # 461: Breath Stacking

Author: Gretchen Hinson, MD Educational Pearls: Breath stacking occurs when a patient is unable to expire fully before another inspiration In intubated/ventilated patients, this is because adequate t...

24 Apr 20195min

Podcast # 460: Hunting for PE in Syncope

Podcast # 460: Hunting for PE in Syncope

Author: Michael Hunt, MD Educational Pearls: Most causes of syncope are benign Pulmonary embolism can result in syncope and is life threatening A recent study of Canadian and US ED patients with s...

22 Apr 20192min

Podcast # 459 Clonidine Ingestion

Podcast # 459 Clonidine Ingestion

Author: Julian Orenstein, MD Educational Pearls: Severe clonidine ingestion can present as a fluctuating mental status between typically accompanied by changes in vital signs (hypotension/bradycar...

20 Apr 20193min

Populärt inom Vetenskap

p3-dystopia
dumma-manniskor
svd-nyhetsartiklar
allt-du-velat-veta
kapitalet-en-podd-om-ekonomi
rss-vetenskapsradion
rss-ufo-bortom-rimligt-tvivel
medicinvetarna
rss-vetenskapsradion-2
rss-experimentet
det-morka-psyket
sexet
rss-spraket
hacka-livet
dumforklarat
pojkmottagningen
rss-personlighetspodden
rss-arkeologi-historia-podden-som-graver-i-vart-kulturlandskap
paranormalt-med-caroline-giertz
halsorevolutionen