Podcast # 470: Zofran and Pregnancy

Podcast # 470: Zofran and Pregnancy

Author: Jared Scott, MD

Educational Pearls:

  • Ondansetron (Zofran) is one of the latest drugs that has had concerns raised about side effects, particularly in pregnancy
  • 2018 study probed two birth defect databases to assess increases in 51 major birth defects with increased exposure to ondansetron
  • Only two of the 51 had even a modest increase, which is unclear in causation (cleft palate and renal agenesis)
  • When administering ondansetron (or any drug) to pregnant women, be able to discuss any potential risks for an informed decision by the patient

Editor's note: in this study, adjusted odds ratios for risk of birth defects from exposure to ondansetron were: cleft palate 1.6 (95% CI 1.1-2.3) and renal agenesis 1.8 (95% CI 1.1-3.0)

References

Parker SE, Van Bennekom C, Anderka M, Mitchell AA. Ondansetron for Treatment of Nausea and Vomiting of Pregnancy and the Risk of Specific Birth Defects. Obstet Gynecol. 2018 Aug;132(2):385-394. doi: 10.1097/AOG.0000000000002679. PubMed PMID: 29995744.

Summarized by Will Dewispelaere, MS3 | Edited by Erik Verzemnieks, MD



Avsnitt(1146)

Podcast # 367: Digital Necrosis after Epinephrine Drip

Podcast # 367: Digital Necrosis after Epinephrine Drip

Podcast # 367: Digital Necrosis after Epinephrine Drip Author: Jared Scott, MD. Educational Pearls: Make sure to monitor for limb ischemia in all patients on vasopressors Good reminder that vasop...

17 Aug 20184min

Podcast # 366: Ehlers Danlos

Podcast # 366: Ehlers Danlos

Podcast # 366: Ehlers Danlos Author: Gretchen Hinson, MD. Educational Pearls: Heritable mutation in collagen synthesis and expression commonly resulting in joint hyperextension and skin elasticity....

15 Aug 20184min

Podcast # 365: Renal Trigger Point Injections

Podcast # 365: Renal Trigger Point Injections

Author: Erik Verzemnieks, MD Educational Pearls: Single study in Japan demonstrated possible effectiveness of renal colic trigger point Patients had injection at the area of maximal tenderness on...

13 Aug 20181min

Podcast # 364: Other causes of ST elevation

Podcast # 364: Other causes of ST elevation

Author: Peter Bakes, MD Educational Pearls: Pericarditis, LBBB, LVH and left ventricular aneurysms can all present with ST elevation. Ventricular aneurysm will present days after a cardiac event ...

10 Aug 20186min

Podcast # 363:  Ketamine for Alcohol Withdrawal

Podcast # 363: Ketamine for Alcohol Withdrawal

Educational Pearls: Recent study has shown adjunctive ketamine can be useful in setting of alcohol withdrawal. Ketamine was associated with a decrease in the amount of benzodiazepines needed, lik...

8 Aug 20182min

Podcast # 362: Giant Hogweed

Podcast # 362: Giant Hogweed

Author: John Winkler, MD Educational Pearls: Tall flowering plant with phototoxic sap Direct skin contact with the sap can cause the skin to become photosensitive Severe blisters and even burns...

6 Aug 20182min

Podcast # 361: Vertiginous Dizziness

Podcast # 361: Vertiginous Dizziness

Author: Peter Bakes, MD Educational Pearls: Important to find out if patients mean dysequilibrium, lightheadedness, or vertigo when patients say they are "dizzy." Differentiate central vs. periph...

3 Aug 20186min

Podcast # 360: Epidural Abscess Screening

Podcast # 360: Epidural Abscess Screening

Author: Dylan Luyten, MD. Educational Pearls:   Dangerous causes of back pain: AAA, cauda equina syndrome, epidural abscess. Young person with back pain needs to be evaluated for injection drug use...

2 Aug 20184min

Populärt inom Vetenskap

dumma-manniskor
svd-nyhetsartiklar
p3-dystopia
kapitalet-en-podd-om-ekonomi
allt-du-velat-veta
rss-ufo-bortom-rimligt-tvivel
det-morka-psyket
medicinvetarna
rss-vetenskapsradion
rss-vetenskapsradion-2
sexet
rss-experimentet
pojkmottagningen
hacka-livet
rss-spraket
dumforklarat
rss-broccolipodden-en-podcast-som-inte-handlar-om-broccoli
halsorevolutionen
bildningspodden
rss-arkeologi-historia-podden-som-graver-i-vart-kulturlandskap