Podcast 534: Nerve Agents

Podcast 534: Nerve Agents

Author: Michael Hunt, MD

Educational Pearls:

  • Organophosphate "nerve agents" were developed in the 1930's
  • These agents have cholinergic effects, which can be remembered by the mnemonic "SLUDGE"
    • Salivation
    • Lacrimation
    • Urination
    • Defecation
    • GI cramping
    • Emesis
  • The "SLUDGE" toxidrome is mediated through the muscarinic acetylcholine receptors. Nerve agents also affect the nicotinic acetylcholine receptors, which leads to muscle paralysis
  • Death in these cases is from respiratory collapse due to secretions (bronchorrhea) and diaphragmatic paralysis
  • Treatment includes atropine to reduce secretions (often in incredibly high doses) and pralidoxime (2-PAM) to treat muscle paralysis
  • Benzodiazepines may be necessary for seizures

References

https://www.osha.gov/SLTC/emergencypreparedness/guides/nerve.html

Michael Eddleston Novel Clinical Toxicology and Pharmacology of Organophosphorus Insecticide Self-Poisoning. Annual Review of Pharmacology and Toxicology 2019 59:1, 341-360

Summarized by Will Dewispelaere, MS4 | Edited by Erik Verzemnieks, MD



Avsnitt(1147)

COVID-19 Digest: The Possible Link Between Severe COVID-19 and Low Vitamin D Levels (Recorded 5/21/20)

COVID-19 Digest: The Possible Link Between Severe COVID-19 and Low Vitamin D Levels (Recorded 5/21/20)

Host: Elizabeth Esty, MD. At this point, with so many of the studies we've digested exploring correlations, associations, observational studies and anecdotal reports and speculation, we could subtitle...

22 Maj 202018min

On the Streets #5: Trauma during COVID-19

On the Streets #5: Trauma during COVID-19

Jordan sits down to discuss trauma with Dr. Kaysie Banton, the Trauma Services Medical Director at Level 1 Trauma Center Swedish Medical Center in Englewood, Colorado. In this laid back interview, Dr....

20 Maj 202026min

Podcast 564:  Cardiac Ischemia Management Update

Podcast 564: Cardiac Ischemia Management Update

Contributor: Nick Tsipis, MD Educational Pearls: Recent randomized controlled trial compared early intervention (PCI/CABG) to medical management for those diagnosed with moderate to severe cardiac is...

19 Maj 20205min

Podcast 563:  DC ACs

Podcast 563: DC ACs

Contributor: Nick Hatch, MD Educational Pearls: An AC (acromioclavicular joint) separation in the shoulder is a common traumatic injury XRs can help rule out other injuries as well as help with gradi...

18 Maj 20202min

COVID-19 Digest: Could Cigarette Smoking Actually be Protective Against COVID?

COVID-19 Digest: Could Cigarette Smoking Actually be Protective Against COVID?

Host: Elizabeth Esty, MD. Smoking is known to increase both susceptibility and severity of all manner of colds and pneumonias, so you'd think the world's 1.1 billion smokers would be at risk in this p...

13 Maj 202018min

Podcast 562:  COVID-19 Occlusions

Podcast 562: COVID-19 Occlusions

Contributor: Nick Tsipis, MD Educational Pearls: Case series reported 5 cases of generally young and healthy patients with COVID-19 who presented to the ER with acute stroke Now several case series s...

12 Maj 20202min

Podcast 561:  Give Bup

Podcast 561: Give Bup

Contributor: Don Stader, MD Educational Pearls: Buprenorphine has been shown to decrease morbidity and mortality in opioid use disorder Buprenorphine used in naloxone-induced withdrawals can displace...

11 Maj 20204min

COVID-19 Digest: Bacille Calmette-Guérin (BCG) Vaccine for Treating COVID-19

COVID-19 Digest: Bacille Calmette-Guérin (BCG) Vaccine for Treating COVID-19

In the US, few people receive vaccination for tuberculosis (TB), a disease that hasn't been a major killer here for many decades. But while we in the US mostly experience TB as a relatively rare but ...

8 Maj 202014min

Populärt inom Vetenskap

p3-dystopia
dumma-manniskor
svd-nyhetsartiklar
allt-du-velat-veta
kapitalet-en-podd-om-ekonomi
rss-vetenskapsradion
rss-ufo-bortom-rimligt-tvivel
medicinvetarna
rss-vetenskapsradion-2
rss-experimentet
det-morka-psyket
sexet
rss-spraket
hacka-livet
dumforklarat
pojkmottagningen
rss-personlighetspodden
rss-arkeologi-historia-podden-som-graver-i-vart-kulturlandskap
paranormalt-med-caroline-giertz
halsorevolutionen