Podcast 534: Nerve Agents

Podcast 534: Nerve Agents

Author: Michael Hunt, MD

Educational Pearls:

  • Organophosphate "nerve agents" were developed in the 1930's
  • These agents have cholinergic effects, which can be remembered by the mnemonic "SLUDGE"
    • Salivation
    • Lacrimation
    • Urination
    • Defecation
    • GI cramping
    • Emesis
  • The "SLUDGE" toxidrome is mediated through the muscarinic acetylcholine receptors. Nerve agents also affect the nicotinic acetylcholine receptors, which leads to muscle paralysis
  • Death in these cases is from respiratory collapse due to secretions (bronchorrhea) and diaphragmatic paralysis
  • Treatment includes atropine to reduce secretions (often in incredibly high doses) and pralidoxime (2-PAM) to treat muscle paralysis
  • Benzodiazepines may be necessary for seizures

References

https://www.osha.gov/SLTC/emergencypreparedness/guides/nerve.html

Michael Eddleston Novel Clinical Toxicology and Pharmacology of Organophosphorus Insecticide Self-Poisoning. Annual Review of Pharmacology and Toxicology 2019 59:1, 341-360

Summarized by Will Dewispelaere, MS4 | Edited by Erik Verzemnieks, MD



Avsnitt(1147)

On the Streets #3: COVID-19

On the Streets #3: COVID-19

In this special edition of our On the Streets podcast, we discuss COVID-19 as well as what first responders and emergency providers need to know to keep themselves and their patients safe during this ...

19 Mars 202020min

Podcast 550: Good ol' Versed

Podcast 550: Good ol' Versed

Contributor: Sam Killian, MD Educational Pearls: Agitation can be due to a number of causes, but regardless of the cause, sedation often plays a key role in patient and provider safety. But what is t...

17 Mars 20204min

Podcast 549:  Just Use Epineprhine

Podcast 549: Just Use Epineprhine

Contributor: Sam Killian, MD Educational Pearls: Classic dogma teaching that epinephrine should not be used in the fingers, nose, penis, and toes when performing local anesthesia due to concerns for ...

16 Mars 20203min

On the Streets #2: Neurological Deficits

On the Streets #2: Neurological Deficits

Part 1 of 2: Dr. Adam Graham dishes out the essentials of identifying concerning neurological deficits on the scene, predicting what they mean and how to best care for patients with neurological defic...

11 Mars 202020min

Podcast 548:  Adrenal Crisis

Podcast 548: Adrenal Crisis

Contributor: Nick Tsipis, MD Educational Pearls: Congenital adrenal hyperplasia (CAH) is a group of enzyme deficiencies in the adrenals leading to a deficiency of hormones normally synthesized by the...

10 Mars 20205min

Podcast 547: Capsaicin Cream to the Rescue

Podcast 547: Capsaicin Cream to the Rescue

Author: Aaron Lessen, MD Educational Pearls: A recent retrospective study looked capsaicin cream in treating cannabinoid hyperemesis syndrome in regards to length of stay, cost analysis, use of rescu...

9 Mars 20201min

Podcast 546: Complete Heart Block

Podcast 546: Complete Heart Block

Author: Jared Scott, MD Educational Pearls: Differentiating symptomatic bradycardia from asymptomatic may be essential in determining workup and treatment Airway, breath, circulation always hold true...

3 Mars 20203min

Podcast 545: So You Quit Smoking… Now What?

Podcast 545: So You Quit Smoking… Now What?

Author: Aaron Lessen, MD Educational Pearls: New data shows within 5 years of smoking cessation, the risk of cardiovascular disease becomes half of those who continue to smoke After 10-15 years of c...

2 Mars 20201min

Populärt inom Vetenskap

p3-dystopia
dumma-manniskor
svd-nyhetsartiklar
allt-du-velat-veta
medicinvetarna
rss-ufo-bortom-rimligt-tvivel
rss-experimentet
rss-vetenskapsradion-2
rss-vetenskapsradion
det-morka-psyket
sexet
kapitalet-en-podd-om-ekonomi
hacka-livet
dumforklarat
pojkmottagningen
rss-arkeologi-historia-podden-som-graver-i-vart-kulturlandskap
rss-personlighetspodden
paranormalt-med-caroline-giertz
vetenskap-och-halsa
halsorevolutionen