Podcast 534: Nerve Agents

Podcast 534: Nerve Agents

Author: Michael Hunt, MD

Educational Pearls:

  • Organophosphate "nerve agents" were developed in the 1930's
  • These agents have cholinergic effects, which can be remembered by the mnemonic "SLUDGE"
    • Salivation
    • Lacrimation
    • Urination
    • Defecation
    • GI cramping
    • Emesis
  • The "SLUDGE" toxidrome is mediated through the muscarinic acetylcholine receptors. Nerve agents also affect the nicotinic acetylcholine receptors, which leads to muscle paralysis
  • Death in these cases is from respiratory collapse due to secretions (bronchorrhea) and diaphragmatic paralysis
  • Treatment includes atropine to reduce secretions (often in incredibly high doses) and pralidoxime (2-PAM) to treat muscle paralysis
  • Benzodiazepines may be necessary for seizures

References

https://www.osha.gov/SLTC/emergencypreparedness/guides/nerve.html

Michael Eddleston Novel Clinical Toxicology and Pharmacology of Organophosphorus Insecticide Self-Poisoning. Annual Review of Pharmacology and Toxicology 2019 59:1, 341-360

Summarized by Will Dewispelaere, MS4 | Edited by Erik Verzemnieks, MD



Avsnitt(1146)

Podcast #407:  Choose your own blister adventure

Podcast #407: Choose your own blister adventure

Author: Don Stader, MD Educational Pearls:   Three options for a blister in partial thickness burns:  do nothing, unroof it, or poke a hole in it Recent study suggest that aspirating the blister may ...

21 Nov 20181min

Podcast #406:  PO vs. IV Tylenol

Podcast #406: PO vs. IV Tylenol

Author: Don Stader, MD Educational Pearls: Intravenous Tylenol currently is many times more expensive than oral Single ED study comparing the two has methodology flaws and there is a lack of additi...

19 Nov 20182min

Podcast #405:  Infant Walkers

Podcast #405: Infant Walkers

Author: Don Stader, MD Educational Pearls: Recent study has revealed that infant walkers are more harmful than helpful Infant walkers can also delay motor function The American Academy of Pediatric...

16 Nov 201822s

Podcast #404: Electric Scooter Injuries

Podcast #404: Electric Scooter Injuries

Author: Sam Killian, MD Educational Pearls: Recent news articles are showing an increase in injuries related to riding electric scooters Year-to-year, scooter injuries have increased as high as thr...

14 Nov 20182min

Podcast #403:  Meniscus Lock

Podcast #403: Meniscus Lock

Author: Mark Hinton, MD Educational Pearls: Meniscus lock can occur with a tear leading to inability to extend the knee Treatment can include an intra-articular joint block followed by straightenin...

12 Nov 20183min

Podcast #402: Rapid sequence intubation medications

Podcast #402: Rapid sequence intubation medications

Educational Pearls: RSI includes induction agent (sedative) and a paralytic Succinylcholine is a depolarizing paralytic of rapid onset and short duration with contraindications in hyperkalemic states...

9 Nov 20184min

Podcast #401: Foreign Body Aspiration

Podcast #401: Foreign Body Aspiration

Author: Gretchen Hinson, MD Educational Pearls: Diagnosis can be difficult and often delayed Asymmetric breath sounds, choking, stridor may be present, but children also present asymptomatically Peak...

6 Nov 20186min

Podcast #400: ECMO

Podcast #400: ECMO

Author: Dylan Luyten, MD Educational Pearls: Extracorporeal membrane oxygenation (ECMO) is similar to bypass ECMO is being utilized routinely at some centers and even prehospital in cardiac arrest ...

2 Nov 20186min

Populärt inom Vetenskap

p3-dystopia
dumma-manniskor
svd-nyhetsartiklar
allt-du-velat-veta
kapitalet-en-podd-om-ekonomi
rss-ufo-bortom-rimligt-tvivel
det-morka-psyket
rss-vetenskapsradion
medicinvetarna
rss-vetenskapsradion-2
rss-experimentet
sexet
hacka-livet
rss-spraket
dumforklarat
pojkmottagningen
rss-arkeologi-historia-podden-som-graver-i-vart-kulturlandskap
rss-broccolipodden-en-podcast-som-inte-handlar-om-broccoli
halsorevolutionen
paranormalt-med-caroline-giertz