Podcast 544: C is for Sepsis

Podcast 544: C is for Sepsis

Author: Aaron Lessen, MD

Educational Pearls:

  • Previously, trials had shown promising evidence that vitamin C may improve mortality rates in patients with sepsis or septic shock.
  • A 2017 retrospective before-after study gave a "cocktail" of hydrocortisone, vitamin C, and thiamine to patients with severe sepsis or in septic shock and reported a decrease in mortality from 40% to 8%.
  • A 2020 randomized controlled trial demonstrated that giving patients hydrocortisone, vitamin C, and thiamine showed no benefits in improving sepsis outcomes.
  • Currently use of Vitamin C in sepsis and septic shock remains controversial due to lack of sufficient data

References

1) Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. Chest. 2017;151(6):1229. Epub 2016 Dec 6.

2) Fujii T, Luethi N, Young PJ, et al. Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial. JAMA. 2020;323(5):423–431. doi:10.1001/jama.2019.22176

Summarized by Jackson Roos, MS3 | Edited by Erik Verzemnieks, MD



Avsnitt(1147)

Podcast # 392: Maggot Therapy

Podcast # 392: Maggot Therapy

Author: Jared Scott, MD Educational Pearls: Interest started as it was noticed soldiers who had wounds infected with maggots had better outcomes than those without maggots Studies have shown that wou...

15 Okt 20183min

Podcast # 391: Necrotizing Fasciitis

Podcast # 391: Necrotizing Fasciitis

Author: Peter Bakes, MD Educational Pearls: Necrotizing fasciitis is an infection of the deep soft tissues with destruction of the muscle fascia and overlying fat Think of it if pain is out of prop...

12 Okt 20186min

Podcast # 390: Haloperidol for Pain

Podcast # 390: Haloperidol for Pain

Author: Gretchen Hinson, MD Educational Pearls: Reasonable approach of haloperidol 10 mg IM (or 5 mg IV) for pain relief in opioid-dependent patients; can repeat once Chronic opioid use results in ...

10 Okt 20185min

Podcast #389: BRUE

Podcast #389: BRUE

Educational Pearls: BRUE (Brief Resolved Unexplained Event) replaces what was previously called ALTE BRUE describes an event in a child less than one year of age with one or more of the following...

8 Okt 20184min

Podcast #388: Antibiotics for Appendicitis

Podcast #388: Antibiotics for Appendicitis

Author: Aaron Lessen, MD Educational Pearls: 5-year follow up study on antibiotic treatment for uncomplicated appendicitis showed 39.1% recurrence rate requiring appendectomy by 5 years Nearly 6...

5 Okt 20182min

Podcast #387: Fluoroquinolones are Perfectly Safe?

Podcast #387: Fluoroquinolones are Perfectly Safe?

Author: Don Stader, MD Educational Pearls: Fluoroquinolones can cause connective tissue disruption leading not only to tendon rupture but also aortic dissection Retrospective study from Taiwan s...

3 Okt 20183min

Podcast #386: Respecting Transgender Patients

Podcast #386: Respecting Transgender Patients

Author: Kasey Champion, MD Educational Pearls: Transgender populations are frequent victims of discrimination in healthcare Ask transgender patients what their preferred pronoun is It is somet...

1 Okt 20183min

Podcast #385: Probiotics

Podcast #385: Probiotics

Author: John Winkler, MD Educational Pearls: Probiotics are bacteria that are ingested to promote gut health but recent research casts doubt on their effectiveness. Recent study suggests that most...

28 Sep 20182min

Populärt inom Vetenskap

p3-dystopia
dumma-manniskor
svd-nyhetsartiklar
allt-du-velat-veta
kapitalet-en-podd-om-ekonomi
rss-vetenskapsradion-2
sexet
rss-ufo-bortom-rimligt-tvivel
medicinvetarna
hacka-livet
det-morka-psyket
dumforklarat
rss-experimentet
rss-vetenskapsradion
paranormalt-med-caroline-giertz
rss-spraket
pojkmottagningen
halsorevolutionen
rss-personlighetspodden
4health-med-anna-sparre