Podcast 574:  Cyanide Toxicity

Podcast 574: Cyanide Toxicity

Contributor: Nick Tsipis, MD

Educational Pearls:

  • Significant cyanide exposure most commonly occurs from fire/smoke exposure particularly when plastics are involved
  • Cyanide binds to cytochrome oxidase leading to the use of anaerobic metabolism which causes a profound lactic acidosis
  • Classic toxicity includes a rapid loss of consciousness, hypotension, bradycardia, respiratory depression, and seizures
  • Mild exposures can lead to nausea/vomiting, headaches, and other nonspecific symptoms.
  • Sometimes patients will complain of an almond taste.
  • Cyanide toxicity will manifest on labs by a profound anion gap acidosis with elevated lactate (but don't wait for them to ponder the diagnosis)
  • Antidote is hydroxocobalamin and sodium thiosulfate
  • Severe cyanide exposure will likely need ICU level care until the blood gas levels return to their baselines and the lactic acidosis resolves

References

Nickson Chris C, Australian Centre for Health Innovation at Alfred Health. Cyanide Poisoning • LITFL • CCC Toxicology. Life in the Fast Lane • LITFL • Medical Blog. https://litfl.com/cyanide-poisoning-ccc/. Published April 2, 2019. Accessed June 11, 2020.

Parker-Cote JL, Rizer J, Vakkalanka JP, Rege SV, Holstege CP. Challenges in the diagnosis of acute cyanide poisoning. Clin Toxicol (Phila). 2018;56(7):609‐617. doi:10.1080/15563650.2018.1435886

MacLennan L, Moiemen N. Management of cyanide toxicity in patients with burns. Burns. 2015;41(1):18‐24. doi:10.1016/j.burns.2014.06.001

Summarized by Jackson Roos, MS4 | Edited by Erik Verzemnieks, MD



Avsnitt(1147)

Podcast 622: High Altitude Pulmonary Edema (HAPE)

Podcast 622: High Altitude Pulmonary Edema (HAPE)

Contributor: Thomas Seibert, MD Educational Pearls: High Altitude Pulmonary Edema (HAPE) typically occurs 2-4 days after arriving at elevation Symptoms include: Fatigue Dyspnea Cough Treatment in...

15 Dec 20204min

Podcast 621: Pediatric Psychosis

Podcast 621: Pediatric Psychosis

Contributor: Aaron Lessen, MD Educational Pearls: Schizophrenia typically doesn't present until age 13 and has a prodrome Prodrome includes months of gradual changes in behavior, starting with negati...

14 Dec 20203min

Pharmacy Phriday #5: COVID-19 Vaccine for Pregnant Women

Pharmacy Phriday #5: COVID-19 Vaccine for Pregnant Women

Contributors: Rachael Duncan, PharmD and Sean McCullough, PharmD Educational Pearls: A 2019 Report by the National Women's Law Center: Most common occupations for pregnant workers are elementary and ...

11 Dec 202019min

Podcast 620: Prolactin and Seizures

Podcast 620: Prolactin and Seizures

Contributor: Aaron Lessen, MD Educational Pearls: Serum prolactin levels can be used to help differentiate epileptic seizures from non-epileptic seizures It is also released and elevated after epilep...

8 Dec 20203min

Podcast 619: Other Uses for Zyprexa

Podcast 619: Other Uses for Zyprexa

Contributor: Don Stader, MD Educational Pearls: Zyprexa (olanzapine) is a second generation antipsychotic with multiple other uses Excellent for treating nausea in patients undergoing chemotherapy or...

7 Dec 20204min

Podcast 618: Treating Opiate Side Effects

Podcast 618: Treating Opiate Side Effects

Contributor: Don Stader, MD Educational Pearls: Majority of patients experience side effects while taking opioids Most common include nausea/vomiting, puriitis, constipation; more severe and less com...

1 Dec 20204min

Podcast 617: Masks and Understanding Data

Podcast 617: Masks and Understanding Data

Contributor: Peter Bakes, MD Educational Pearls: Recent study looked at if mask wearing protects the mask wearer from infection This group found 1.8% of mask wearers got COVID while 2.1% of non-mask ...

30 Nov 20204min

Pharmacy Phriday #4: mRNA Vaccines

Pharmacy Phriday #4: mRNA Vaccines

Contributor: Rachael Duncan, PharmD Educational Pearls: ED visits nationwide declined by 42% in April 2020 compared to the same time in 2019 largely due to the fear of the COVID-19 pandemic. The big...

27 Nov 202016min

Populärt inom Vetenskap

p3-dystopia
dumma-manniskor
svd-nyhetsartiklar
allt-du-velat-veta
medicinvetarna
rss-ufo-bortom-rimligt-tvivel
kapitalet-en-podd-om-ekonomi
rss-experimentet
rss-vetenskapsradion-2
sexet
rss-vetenskapsradion
hacka-livet
det-morka-psyket
dumforklarat
rss-spraket
pojkmottagningen
rss-arkeologi-historia-podden-som-graver-i-vart-kulturlandskap
4health-med-anna-sparre
halsorevolutionen
rss-personlighetspodden