Podcast 585:  You Sure You Want Colchicine for Gout?

Podcast 585: You Sure You Want Colchicine for Gout?

Contributor: Don Stader, MD

Educational Pearls:

  • Gout is an arthritis caused by the deposition of urate crystals into the joint space
  • Colchicine works by disrupting microtubules and prevents white blood cells from getting into the joint space which stops the inflammatory response
  • Colchicine has a high rate of adverse events, in particular explosive diarrhea
  • The drug also has a very narrow therapeutic index and overdose is nearly universally fatal, with no antidote or effective treatment option available
  • Alternative agents such as steroids, which reduce the inflammatory response to urate crystals, along with NSAIDs may be better options for treatment

References

Angelidis C, Kotsialou Z, Kossyvakis C, et al. Colchicine Pharmacokinetics and Mechanism of Action. Curr Pharm Des. 2018;24(6):659-663. doi:10.2174/1381612824666180123110042

Finkelstein Y, Aks SE, Hutson JR, et al. Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol (Phila). 2010;48(5):407-414. doi:10.3109/15563650.2010.495348

Dalbeth N, Merriman TR, Stamp LK. Gout. Lancet. 2016;388(10055):2039-2052. doi:10.1016/S0140-6736(16)00346-9

Summarized by Jackson Roos, MS4 | Edited by Erik Verzemnieks, MD



Avsnitt(1149)

Episode 963: Antihypertensives and Emergency Room Considerations

Episode 963: Antihypertensives and Emergency Room Considerations

Contributor: Alec Coston, MD Educational Pearls: For patients presenting to the emergency room with hypertension, clinicians should determine if it is isolated and uncomplicated, or involves comorbidi...

30 Juni 20254min

Episode 962: HEART Score

Episode 962: HEART Score

Contributor: Taylor Lynch, MD Educational Pearls: How do we risk-stratify chest-pain patients? One option is the HEART score This score predicts a patient's 6-week risk of a major adverse cardiac ev...

23 Juni 20254min

Episode 961: Cell Phone Sign

Episode 961: Cell Phone Sign

Contributor: Aaron Lessen, MD Educational Pearls: A prospective study at the Mayo Clinic Rochester was conducted to examine whether patients actively using their phones on initial assessment in the E...

16 Juni 20251min

Episode 960: Frank's Sign - A Marker for Coronary Artery Disease

Episode 960: Frank's Sign - A Marker for Coronary Artery Disease

Contributor: Travis Barlock MD Educational Pearls Frank's sign is a curious physical exam finding first described in the literature in 1973 Bilateral earlobe creases are recognized as a marker of co...

9 Juni 20251min

Episode 959: The KLM Flight Disaster and Lessons in Healthcare Communication

Episode 959: The KLM Flight Disaster and Lessons in Healthcare Communication

Contributor: Taylor Lynch, MD Educational Pearls: The KLM Flight Disaster, also known as the Tenerife Airport Disaster, occurred on 27 March 1977. It involved the collision of two Boeing 747 passenger...

2 Juni 20256min

Episode 958: Intranasal Fentanyl

Episode 958: Intranasal Fentanyl

Contributor: Aaron Lessen, MD Educational Pearls: How do we take care of kids in severe pain? There are many non-pharmacologic options for pain (i.e. ice, elevation) as well as more conventional medi...

26 Maj 20251min

Episode 957: Cardiac Asthma

Episode 957: Cardiac Asthma

Contributor: Travis Barlock, MD Educational Pearls: Wheezing is classically heard in asthma and COPD, but it can be the result of a wide range of processes that cause airflow limitation Narrowed bro...

19 Maj 20253min

Episode 956: Psychedelics and Risk of Schizophrenia

Episode 956: Psychedelics and Risk of Schizophrenia

Contributor: Jorge Chalit-Hernandez, OMS3 Educational Pearls: Psychedelics are being studied for their therapeutic effects in mental illnesses, including major depressive disorder, post-traumatic str...

12 Maj 20252min

Populärt inom Vetenskap

dumma-manniskor
p3-dystopia
svd-nyhetsartiklar
allt-du-velat-veta
kapitalet-en-podd-om-ekonomi
rss-vetenskapsradion-2
medicinvetarna
rss-ufo-bortom-rimligt-tvivel-2
rss-vetenskapsradion
det-morka-psyket
bildningspodden
sexet
paranormalt-med-caroline-giertz
halsorevolutionen
hacka-livet
rss-spraket
har-vi-akt-till-mars-an
dumforklarat
rss-geopodden-2
rss-experimentet