Pharmacy Phriday #2: Penicillin and Cephalosporin Allergies

Pharmacy Phriday #2: Penicillin and Cephalosporin Allergies

The penicillin and cephalosporin drug classes include many first line drug options for infectious disease although high rates of self-reported allergies may cause physicians to seek alternative options. In part two of our dive into antibiotics use for infectious disease, listen as Dr. Rachael Duncan, Emergency Medicine Clinical Pharmacist, addresses the need to investigate the validity of these reported allergies and their severity to avoid us elf riskier alternatives, like fluoroquinolones. Cross-reactivity between cephalosporins is most often dictated by side chain of cephalosporins rather than the beta-lactam ring. Refer to the chart included for cross-reactivity tips.

References:

  1. Li M, Krishna MT, Razaq S, Pillay D. A real-time prospective evaluation of clinical pharmaco-economic impact of diagnostic label of 'penicillin allergy' in a UK teaching hospital. J Clin Pathol 2014; 67(12): 1088-92.

  2. Romano A, Gueant-Rodriguez RM, Viola M, Pettinato R, Gueant JL. Cross-reactivity and tolerability of cephalosporins in patients with immediate hypersensitivity to penicillins. Ann Intern Med 2004; 141(1): 16-22.

  3. Macy E, Contreras R. Health care use and serious infection prevalence associated with penicillin "allergy" in hospitalized patients: A cohort study. J Allergy Clin Immunol 2014; 133(3): 790-6

Avsnitt(1145)

Podcast 774: Maggots

Podcast 774: Maggots

Contributor: Chris Holmes, MD Educational Pearls: Maggots were discovered as a therapy to help wound healing in WWI, but this fell out of favor after the discovery of penicillin One study from Israel...

19 Apr 20225min

Podcast 773: Atrial Fibrillation Medications

Podcast 773: Atrial Fibrillation Medications

Contributor: Aaron Lessen, MD Educational Pearls: Atrial fibrillation is an irregular heart rhythm that sometimes requires rate control in setting of rapid ventricular response (RVR) Calcium channel ...

18 Apr 20223min

Podcast 772: Firearms in Suicidal Ideation

Podcast 772: Firearms in Suicidal Ideation

Contributor: Aaron Lessen, MD Educational Pearls: Firearms are a dangerous potential method of committing suicide Death occurs in about 5-15% of suicide attempts overall, but death in suicide attempt...

12 Apr 20224min

Podcast 771: Intubation in Cardiac Arrest

Podcast 771: Intubation in Cardiac Arrest

Contributor: Don Stader, MD Educational Pearls: In a secondary analysis of the PART trial, the mortality effect of timing of airway management for patients in cardiac arrest was examined Study looked...

11 Apr 20223min

Podcast 770: Xylazine

Podcast 770: Xylazine

Contributor: Don Stader, MD Educational Pearls: Xylazine, referred to as tranq dope colloquially, is an FDA approved animal tranquilizer that is circulating in the illicit drug markets of the northea...

5 Apr 20223min

Podcast 769: Pressors After Cardiac Arrest

Podcast 769: Pressors After Cardiac Arrest

Contributor: Aaron Lessen, MD Educational Pearls: Hypotension after cardiac arrest often requires a vasopressor to improve blood pressure Recent observational study from France examined outcomes of p...

4 Apr 20223min

Mental Health Monthly #11: De-escalation: Changing Confrontation to Collaboration

Mental Health Monthly #11: De-escalation: Changing Confrontation to Collaboration

Contributor: Dr. Kimberly Nordstrom De-escalation usually takes less time than physical and chemical restraints, which leads to decreased injury to staff members, better patient trust and increased p...

30 Mars 202216min

Podcast 768: Takotsubo Cardiomyopathy

Podcast 768: Takotsubo Cardiomyopathy

Contributor: Peter Bakes, MD Educational Pearls: 3% of cases of acute coronary syndrome are due to Takotsubo Takotsubo cardiomyopathy or "broken heart syndrome" can occur with severe physiologic or ...

29 Mars 20224min

Populärt inom Vetenskap

p3-dystopia
dumma-manniskor
svd-nyhetsartiklar
allt-du-velat-veta
kapitalet-en-podd-om-ekonomi
det-morka-psyket
pojkmottagningen
dumforklarat
rss-vetenskapsradion-2
rss-vetenskapsradion
sexet
halsorevolutionen
rss-ufo-bortom-rimligt-tvivel
rss-spraket
rss-experimentet
vetenskapsradion
rss-broccolipodden-en-podcast-som-inte-handlar-om-broccoli
medicinvetarna
bildningspodden
4health-med-anna-sparre