Pharmacy Phriday #2: Penicillin and Cephalosporin Allergies

Pharmacy Phriday #2: Penicillin and Cephalosporin Allergies

The penicillin and cephalosporin drug classes include many first line drug options for infectious disease although high rates of self-reported allergies may cause physicians to seek alternative options. In part two of our dive into antibiotics use for infectious disease, listen as Dr. Rachael Duncan, Emergency Medicine Clinical Pharmacist, addresses the need to investigate the validity of these reported allergies and their severity to avoid us elf riskier alternatives, like fluoroquinolones. Cross-reactivity between cephalosporins is most often dictated by side chain of cephalosporins rather than the beta-lactam ring. Refer to the chart included for cross-reactivity tips.

References:

  1. Li M, Krishna MT, Razaq S, Pillay D. A real-time prospective evaluation of clinical pharmaco-economic impact of diagnostic label of 'penicillin allergy' in a UK teaching hospital. J Clin Pathol 2014; 67(12): 1088-92.

  2. Romano A, Gueant-Rodriguez RM, Viola M, Pettinato R, Gueant JL. Cross-reactivity and tolerability of cephalosporins in patients with immediate hypersensitivity to penicillins. Ann Intern Med 2004; 141(1): 16-22.

  3. Macy E, Contreras R. Health care use and serious infection prevalence associated with penicillin "allergy" in hospitalized patients: A cohort study. J Allergy Clin Immunol 2014; 133(3): 790-6

Avsnitt(1146)

Podcast 588: Esmolol for Refractory Ventricular Fibrillation

Podcast 588: Esmolol for Refractory Ventricular Fibrillation

Contributor: Ricky Dhaliwal, MD, JD Educational Pearls: Ventricular Fibrillation (VF) is a potentially fatal cardiac arrhythmia; Refractory VF even more so Epinephrine stimulates alpha and beta recep...

18 Aug 20203min

Podcast 587:  Puppies Preventing Burnout?

Podcast 587: Puppies Preventing Burnout?

Contributor: Jared Scott, MD Educational Pearls: Burnout happens. This study reminds us to take a few minutes on shift to take care of yourself. A new study looked at burnout in ER nurses, residents,...

17 Aug 20204min

On the Streets #7: Burns in the Pre-Hospital and ED Setting

On the Streets #7: Burns in the Pre-Hospital and ED Setting

Burns are low-volume, high-acuity injuries that require special attention and care from the pre-hospital team to the Emergency Department and finally to a dedicated burn unit and ICU. As a first respo...

12 Aug 202048min

Podcast 586:  Toxic Shock Syndrome

Podcast 586: Toxic Shock Syndrome

Contributor: Don Stader, MD Educational Pearls: Toxic shock syndrome (TSS) is a rare cause of shock typically caused by Staph aureus or Strep pyogenes, that produces a toxin that leads to rapid onset...

11 Aug 20206min

Podcast 585:  You Sure You Want Colchicine for Gout?

Podcast 585: You Sure You Want Colchicine for Gout?

Contributor: Don Stader, MD Educational Pearls: Gout is an arthritis caused by the deposition of urate crystals into the joint space Colchicine works by disrupting microtubules and prevents white blo...

10 Aug 20203min

Podcast 584:  Ketamine for Depression and Suicidality

Podcast 584: Ketamine for Depression and Suicidality

Contributor: Jared Scott, MD Educational Pearls: Suicide is currently the 10th leading cause of death in the US  Low quality studies have reported ketamine as a potential promising agent in treating ...

4 Aug 20203min

Podcast 583:  Raise Your Hands if You Have Carpal Tunnel Syndrome

Podcast 583: Raise Your Hands if You Have Carpal Tunnel Syndrome

Contributor: Aaron Lessen, MD Educational Pearls: Hand raising test: a simple but effective tool to diagnose carpal tunnel  Patients hold their hands over their head and if symptoms of carpal tunnel ...

3 Aug 20202min

Rapid Fire Pharmacy Review with Adis Keric of ER-Rx

Rapid Fire Pharmacy Review with Adis Keric of ER-Rx

Meet Adis Keric, Board Certified Pharmacotherapy Specialist and a Board Certified Critical Care pharmacist who works in the Emergency Department and ICU of level 1 trauma center Regions Hospital in Sa...

29 Juli 202018min

Populärt inom Vetenskap

dumma-manniskor
svd-nyhetsartiklar
p3-dystopia
allt-du-velat-veta
kapitalet-en-podd-om-ekonomi
det-morka-psyket
rss-ufo-bortom-rimligt-tvivel
rss-vetenskapsradion
pojkmottagningen
sexet
rss-vetenskapsradion-2
dumforklarat
rss-broccolipodden-en-podcast-som-inte-handlar-om-broccoli
medicinvetarna
halsorevolutionen
bildningspodden
rss-experimentet
rss-spraket
hacka-livet
vetenskapsradion