Podcast 637: LSD

Podcast 637: LSD

Contributor: Katie Sprinkel, MD

Educational Pearls:

  • Commonly known as "acid," LSD is seeing a resurgence in the population as a recreational hallucination
  • Onset is about 30 minutes with peak pharmacologic effects at 2-4 hours, the drug's half life is 3 hours resulting in some prolonged effects
  • While there is not an significant addictive component of LSD, tolerance for LSD does occur and prolonged usage is associated with increased incidence of schizophreniform disorders
  • Hallucinations and pseudo-hallucinations (sensory misperceptions) are typical of LSD intoxication, other common signs of intoxication include nausea, diaphoresis, tachycardia, mydriasis, and hypertension
  • More serious effects can be coma, hyperthermia, seizures, cardiac arrest, serotonin syndrome (with concomitant SSRI use) and coagulopathy, although the dose to cause these effects is very high
  • Treatment is decreasing sensory stimulation, benzodiazepines in some cases, and symptomatic treatment - no specific antidote exists

References

Blaho K, Merigian K, Winbery S, Geraci SA, Smartt C. Clinical pharmacology of lysergic acid diethylamide: case reports and review of the treatment of intoxication. Am J Ther. 1997 May-Jun;4(5-6):211-21. doi: 10.1097/00045391-199705000-00008. PMID: 10423613.

Klock JC, Boerner U, Becker CE. Coma, hyperthermia and bleeding associated with massive LSD overdose. A report of eight cases. West J Med. 1974;120(3):183-188.

Summarized by John Spartz, MS3 | Edited by Erik Verzemnieks, MD



Avsnitt(1145)

Podcast # 342: Scombroid

Podcast # 342: Scombroid

Author: Jared Scott, MD Educational Pearls: Scombroid is a type of food poisoning associated with dark fish (i.e. tuna, salmon, mackerel) that mimics anaphylaxis. Occurs through conversion of histi...

18 Juni 20184min

Podcast # 341: Tenecteplase vs. Alteplase

Podcast # 341: Tenecteplase vs. Alteplase

Author: Rachel Beham, PharmD Educational Pearls: Tenecteplase is more specific for fibrin and has a longer half-life than alteplase. In setting of ischemic stroke, tenecteplase before thrombectomy ...

13 Juni 20183min

Podcast # 340: Drowning

Podcast # 340: Drowning

Author: Chris Holmes, MD Educational Pearls: Epidemiology: 80% male, ages 1-4 at greatest risk, African-American > Caucasian. Freshwater and ocean water may have more bacteria than pool water. ...

11 Juni 20185min

Podcast # 339: Ectopic Pregnancy Risk Factors

Podcast # 339: Ectopic Pregnancy Risk Factors

Author: Jared Scott, MD Educational Pearls: Data is mixed, but some studies show 1-2% of pregnancies are ectopic. Risk factors for ectopic pregnancies include: pelvic inflammatory disease, prior ec...

8 Juni 20185min

Podcast # 338: Mononucleosis predictors

Podcast # 338: Mononucleosis predictors

Author: Chris Holmes, MD Educational Pearls: Symptoms commonly seen with mononucleosis are palatal petechiae, posterior cervical lymphadenopathy, inguinal/axillary lymphadenopathy, splenomegaly, and/...

6 Juni 20182min

Podcast # 337: Airway Burn Inhalation

Podcast # 337: Airway Burn Inhalation

Author: John Winkler, MD Educational Pearls: Singed nasal hairs, soot around mouth, hoarse voice, drooling, and burns to head/face are signs suggestive of inhalation injury. Early intubation is cri...

4 Juni 20186min

Podcast # 336: Hypokalemia

Podcast # 336: Hypokalemia

Author: Dylan Luyten, MD Educational Pearls:   Most important questions to answer with low potassium are 1. What are their symptoms? 2. Can they take potassium by mouth? Oral repletion is faster, c...

31 Maj 20183min

Podcast # 335: Blunt Head Trauma

Podcast # 335: Blunt Head Trauma

Author: Peter Bakes, M.D. Educational Pearls: Epidural hematomas have a characteristic convex appearance on CT while a subdural hematoma will have a concave appearance. Indications for operative ...

29 Maj 20188min

Populärt inom Vetenskap

p3-dystopia
dumma-manniskor
svd-nyhetsartiklar
allt-du-velat-veta
kapitalet-en-podd-om-ekonomi
det-morka-psyket
pojkmottagningen
dumforklarat
rss-vetenskapsradion
rss-vetenskapsradion-2
sexet
halsorevolutionen
rss-ufo-bortom-rimligt-tvivel
rss-experimentet
rss-broccolipodden-en-podcast-som-inte-handlar-om-broccoli
rss-spraket
medicinvetarna
bildningspodden
vetenskapsradion
rss-lara-fran-larda-en-fackbok-och-en-forfattare