Episode 905: Oseltamivir (Tamiflu) for Influenza

Episode 905: Oseltamivir (Tamiflu) for Influenza

Contributor: Aaron Lessem MD

Educational Pearls:

  • Oseltamivir (Tamiflu) is an antiviral medication used commonly to treat influenza

  • Trials show that the medication reduces the duration of illness by less than 1 day (~16 hours in one systematic review)

    • Benefit only occurs if taken within 48 hours of symptom onset

    • Must be taken for 5 days

  • A 2024 meta-analysis reviewed 15 randomized-controlled trials for the risk of hospitalization

    • No reduction in hospitalizations with oseltamivir in patients over the age of 12

    • No difference in high-risk patients over the age of 65 or those with comorbidities

      • The authors note that the confidence interval in these populations is wide, indicating a need for subsequent studies in high-risk populations

  • Oseltamivir is associated with adverse effects including nausea, vomiting, and neurologic symptoms

    • The risk of adverse effects may outweigh the benefits of a small reduction in the duration of illness

References

1. Hanula R, Bortolussi-Courval É, Mendel A, Ward BJ, Lee TC, McDonald EG. Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients with Influenza: A Systematic Review and Meta-Analysis. JAMA Intern Med. 2024;184(1):18-27. doi:10.1001/jamainternmed.2023.0699

2. Jefferson T, Jones M, Doshi P, Spencer EA, Onakpoya I, Heneghan CJ. Oseltamivir for influenza in adults and children: Systematic review of clinical study reports and summary of regulatory comments. BMJ. 2014;348(April):1-18. doi:10.1136/bmj.g2545

Summarized by Jorge Chalit, OMSII | Edited by Meg Joyce & Jorge Chalit

Avsnitt(1145)

Trauma Is A Journey #4 Coming Full Circle

Trauma Is A Journey #4 Coming Full Circle

High in the mountains of Colorado, a crew of unsuspecting docs stumble upon the EMS scene of a head-on collision after an arduous mountain bike ride. Trauma is a Journey is a four part rural trauma mi...

20 Mars 202119min

Trauma Is A Journey #3 What's In Your Jump Kit

Trauma Is A Journey #3 What's In Your Jump Kit

High in the mountains of Colorado, a crew of unsuspecting docs stumble upon the EMS scene of a head-on collision after an arduous mountain bike ride. Trauma is a Journey is a four part rural trauma mi...

19 Mars 202123min

Trauma is a Journey #2 The Complete Antidote to Burnout

Trauma is a Journey #2 The Complete Antidote to Burnout

High in the mountains of Colorado, a crew of unsuspecting docs stumble upon the EMS scene of a head-on collision after an arduous mountain bike ride. Trauma is a Journey is a four part rural trauma mi...

18 Mars 202135min

Trauma is a Journey #1 Setting the Scene

Trauma is a Journey #1 Setting the Scene

High in the mountains of Colorado, a crew of unsuspecting docs stumble upon the EMS scene of a head-on collision after an arduous mountain bike ride. Trauma is a Journey is a four part rural trauma mi...

17 Mars 202130min

Podcast 649: Normal Triage EKGs

Podcast 649: Normal Triage EKGs

Contributor: Samuel Killian, MD Educational Pearls: Anecdotally, when the computer reads a triage EKG as normal it is most often normal One study tested this theory by examining 855 computer-read EK...

16 Mars 20213min

Podcast 648: Ivermectin for COVID-19

Podcast 648: Ivermectin for COVID-19

Contributor: Aaron Lessen, MD Educational Pearls: Ivermectin is an antiparasitic medication that has been used for a long time, but has sparked new interest in the past year as a potential treatment...

15 Mars 20213min

UnfilterED #12: Dr. Don Stader

UnfilterED #12: Dr. Don Stader

If you listen to this podcast, then you're probably familiar with our founder and frequent contributor, Dr. Donald Stader, and his fascination with the intersection of Emergency Medicine, opioids and ...

10 Mars 20211h

Podcast 647: INR and Liver Failure

Podcast 647: INR and Liver Failure

Contributor: Erik Verzemnieks, MD Educational Pearls: INR measures the clotting cascade including factors II, VII, IX, and X Coumadin most commonly elevates the INR, and it is used to monitor the an...

9 Mars 20213min

Populärt inom Vetenskap

svd-nyhetsartiklar
p3-dystopia
dumma-manniskor
pojkmottagningen
allt-du-velat-veta
det-morka-psyket
kapitalet-en-podd-om-ekonomi
rss-experimentet
dumforklarat
rss-vetenskapsradion-2
halsorevolutionen
rss-ufo-bortom-rimligt-tvivel
medicinvetarna
rss-vetenskapsradion
paranormalt-med-caroline-giertz
bildningspodden
rss-spraket
sexet
vetenskapsradion
4health-med-anna-sparre