Episode 905: Oseltamivir (Tamiflu) for Influenza

Episode 905: Oseltamivir (Tamiflu) for Influenza

Contributor: Aaron Lessem MD

Educational Pearls:

  • Oseltamivir (Tamiflu) is an antiviral medication used commonly to treat influenza

  • Trials show that the medication reduces the duration of illness by less than 1 day (~16 hours in one systematic review)

    • Benefit only occurs if taken within 48 hours of symptom onset

    • Must be taken for 5 days

  • A 2024 meta-analysis reviewed 15 randomized-controlled trials for the risk of hospitalization

    • No reduction in hospitalizations with oseltamivir in patients over the age of 12

    • No difference in high-risk patients over the age of 65 or those with comorbidities

      • The authors note that the confidence interval in these populations is wide, indicating a need for subsequent studies in high-risk populations

  • Oseltamivir is associated with adverse effects including nausea, vomiting, and neurologic symptoms

    • The risk of adverse effects may outweigh the benefits of a small reduction in the duration of illness

References

1. Hanula R, Bortolussi-Courval É, Mendel A, Ward BJ, Lee TC, McDonald EG. Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients with Influenza: A Systematic Review and Meta-Analysis. JAMA Intern Med. 2024;184(1):18-27. doi:10.1001/jamainternmed.2023.0699

2. Jefferson T, Jones M, Doshi P, Spencer EA, Onakpoya I, Heneghan CJ. Oseltamivir for influenza in adults and children: Systematic review of clinical study reports and summary of regulatory comments. BMJ. 2014;348(April):1-18. doi:10.1136/bmj.g2545

Summarized by Jorge Chalit, OMSII | Edited by Meg Joyce & Jorge Chalit

Avsnitt(1146)

Podcast 524:  Bacterial Endocarditis

Podcast 524: Bacterial Endocarditis

Contributor: Sue Chilton, MD Educational Pearls: More intracardiac devices and injection drug abuse are thought to be increasing incidence of endocarditis Classic signs of endocarditis have included:...

20 Dec 20193min

Podcast 523:  A Dizzying Diagnosis

Podcast 523: A Dizzying Diagnosis

Contributor: Don Stader, MD Educational Pearls: It can be difficult to distinguish between central and peripheral causes of vertigo. Cerebellar stroke should be considered with any dizzy patient.  Si...

17 Dec 20192min

UnfilterED #3: Dr. Katie Bakes & Dr. Pete Bakes

UnfilterED #3: Dr. Katie Bakes & Dr. Pete Bakes

Husband and wife Pete and Katie Bakes, both emergency physicians in the Denver-Metro area, reflect on their upbringings, the many lessons learned over their twenty year careers, and how they've evolve...

14 Dec 20191h 43min

Podcast 522: e-Cigarette and Vaping Related Lung Injury

Podcast 522: e-Cigarette and Vaping Related Lung Injury

Contributor: John Winkler, MD Educational Pearls: Vaping-related lung injury initially presents with flu-like symptoms and can progress to respiratory failure requiring aggressive resuscitation inclu...

10 Dec 20192min

Podcast 521: Traumatic Hyphema

Podcast 521: Traumatic Hyphema

Author: Jared Scott, MD Educational Pearls: A hyphema is blood in the anterior chamber of the eye, typically caused by trauma While there is a spectrum of disease, blurred vision and eye pain are com...

5 Dec 20192min

Podcast 520:  Approach to the arresting patient

Podcast 520: Approach to the arresting patient

Contributor: Peter Bakes, MD Educational Pearls: Peri-arrest patients present a particular challenge to ED providers, as the differential is broad and time is critical  The differential for near card...

3 Dec 20197min

CBHW Summit: The Cycle of Drug-Related Stigma - Implications for the Opioid Crisis

CBHW Summit: The Cycle of Drug-Related Stigma - Implications for the Opioid Crisis

From DU's 1st annual Colorado Behavioral Health and Wellness Summit: Contributor: Michael Miller, Strategic Initiatives Coordinator, Jefferson County Public Health

27 Nov 201956min

CBHW Summit: A Strategic Framework for Addiction Medicine

CBHW Summit: A Strategic Framework for Addiction Medicine

From DU's 1st annual Colorado Behavioral Health and Wellness Summit: Contributors: Judith Shlay, MD, MSPH, Associate Director, Denver Public Health, and Brooke Bender, MPH, Center for Addiction Medici...

27 Nov 201945min

Populärt inom Vetenskap

p3-dystopia
dumma-manniskor
svd-nyhetsartiklar
allt-du-velat-veta
kapitalet-en-podd-om-ekonomi
det-morka-psyket
rss-ufo-bortom-rimligt-tvivel
sexet
rss-vetenskapsradion
pojkmottagningen
rss-vetenskapsradion-2
dumforklarat
rss-broccolipodden-en-podcast-som-inte-handlar-om-broccoli
halsorevolutionen
rss-spraket
bildningspodden
hacka-livet
rss-experimentet
medicinvetarna
rss-lara-fran-larda-en-fackbok-och-en-forfattare