Dementia Researcher Blogs20 Mars 2024

Ajantha Abey - The Pros and Cons of using iPSCs in Dementia Research

Ajantha Abey narrates his blog written for Dementia Researcher.

Explore Ajantha's insights on the revolutionary impact and challenges of using induced pluripotent stem cells (iPSCs) in dementia research. Ajantha reflects on the journey with iPSC models, highlighting the groundbreaking potential to study diseases like Alzheimer’s and Parkinson’s by examining human brain cells without invasive methods.

The blog emphasises the transformative nature of iPSC technology, which allows for in-depth exploration into the mechanisms of dementia, yet it also brings to light the considerable effort, attention, and resources required to maintain and differentiate these cells.

Through a balanced lens, Ajantha offers a concise overview of the scientific opportunities iPSCs provide against the backdrop of the technical and logistical hurdles researchers face, presenting a clear picture of iPSC technology's role in advancing dementia research.

Find the original text, and narration here on our website.

https://www.dementiaresearcher.nihr.ac.uk/blog-the-pros-and-cons-of-using-ipscs-in-dementia-research/

#iPSCs #StemCells #DementiaResearch

Ajantha Abey is a PhD student in the Kavli Institute at University of Oxford. He is interested in the cellular mechanisms of Alzheimer's, Parkinson's, and other diseases of the ageing brain. Previously, having previoulsy explored neuropathology in dogs with dementia and potential stem cell replacement therapies. He now uses induced pluripotent stem cell derived neurons to try and model selective neuronal vulnerability: the phenomenon where some cells die but others remain resilient to neurodegenerative diseases.

Enjoy listening and reading our blogs? We're always on the look out for new contributors, drop us a line and share your own research and careers advice dementiaresearcher@ucl.ac.uk

This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support.

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