ESICM Talk2 Mars 2022

Effect of therapeutic drug monitoring-based dose optimisation of piperacillin/tazobactam in sepsis patients

Growing evidence suggests that insufficient antibiotic exposure (defined as failure to achieve the pharmacokinetic/pharmacodynamic (PK/PD) target to kill or inhibit the growth of a pathogen) is associated with worse clinical outcomes in sepsis patients.

Moreover, up to 50% of critically ill patients receiving a β-lactam antibiotic with regimens based on manufacturers' recommendations fail to reach the target.

Therapeutic drug monitoring (TDM)-guided therapy has been proposed as a strategy to further optimise the achievement of the PK/PD target of β-lactam antibiotics. However, there are no data on whether piperacillin/tazobactam TDM can improve clinical outcomes.

In this context, a large RCT was performed to investigate whether TDM-based dose optimisation versus fixed dosing could improve clinical outcomes in patients with sepsis treated with piperacillin/tazobactam as a continuous infusion.

Dr Hagel shares with us the results of this study published in the ICM Journal.

Original study:

Hagel S et al. Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial. Intensive Care Med. 2022 Mar;48(3):311-321. doi: 10.1007/s00134-021-06609-6

Speakers

Stefan HAGEL. Assistant medical director and consultant at the Institute for Infectious Diseases and Infection Control and Center for Sepsis Control and Care at the Jena University Hospital (DE).

Laura BORGSTEDT. Department of Anesthesiology, Klinikum rechts der Isar, Technical University of Munich, Munich (DE).

Det här avsnittet är hämtat från ett öppet RSS-flöde och publiceras inte av Podme. Det kan innehålla reklam.

Avsnitt(97)

Large language models in the ICU

Is artificial intelligence about to transform the ICU?In this new episode of the Future of Intensive Care podcast series, we dive into the rapidly evolving world of large language models and their gro...

20 Maj 8min

Advanced Practice in Nursing and Allied Health Professionals

What does advanced practice really look like in the ICU? In this podcast episode, we are joined by two advanced intensive care practitioners who share their roles, career journeys, and impact within t...

13 Maj 43min

Unmet Needs in PICS: Are We Measuring What Matters?

What truly matters in recovery after critical illness? In this episode, we explore the unmet needs in Post-Intensive Care Syndrome (PICS) and question whether current approaches are capturing the outc...

11 Maj 23min

Current state of AI in health and healthcare

Artificial Intelligence (AI) is transforming healthcare—but what does it really mean for the intensive Care Unit (ICU)? In this episode, we are honoured to welcome Prof. Derek Angus, who explores the ...

6 Maj 33min

Healthcare crisis: can innovation be the answer?

Can innovation really transform the future of intensive care?Join the first episode of the ESICM podcast series, The Future of Intensive Care. Prof. Maurizio Cecconi joins Dr Massimiliano Greco to exp...

22 Apr 18min

Redefining Precision Nutrition: Where Science Meets the patient’s bedside

In this episode of the educational podcast, we explore what precision nutrition truly means in intensive care. While the concept is widely discussed in research, many studies remain descriptive or rel...

8 Apr 31min

Why does renal recovery from AKI matter to us intensivists?

Acute Kidney Injury (AKI) is a frequent complication in critically ill patients and is associated with significant morbidity and mortality. However, the clinical relevance of AKI extends well beyond t...

18 Mars 24min