Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on Bayesian forecasting
ESICM Talk14 Feb 2024

Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on Bayesian forecasting

Numerous Population Pharmacokinetic (PopPK) models have been developed for Piperacillin (PIP), most of which are based on small monocentric studies and may not be generalizable to other populations. A recent evaluation of six PIP models in 30 ICU patients receiving CI demonstrated large inter-model variability regarding predictability. The transferability of these results to other populations is uncertain due to the limited number of patients and the monocentric setting. Furthermore, a clinically oriented model assessment in conjunction with TDM (Bayesian forecasting) was lacking.

A recent study aimed to evaluate the predictive performance of available PIP PopPK models with and without TDM using an external multicenter dataset to facilitate model selection for MIPD in critically ill patients. Listen to the podcast and learn more about the methodology and findings of this study.

Det här avsnittet är hämtat från ett öppet RSS-flöde och publiceras inte av Podme. Det kan innehålla reklam.

Avsnitt(97)

Covert Consciousness

Covert Consciousness

9 Apr 202517min

Prehabilitation in the ICU

Prehabilitation in the ICU

Did you know that preparing patients before an ICU stay can lead to better recovery after? Prehabilitation programmes focus on strengthening physical, cognitive, and metabolic health before critical i...

26 Mars 202524min

Post ICU outcomes and follow up

Post ICU outcomes and follow up

Post-Intensive Care Syndrome (PICS) refers to the prolonged impairment of physical, cognitive, and mental health that can occur after an intensive care stay. Its effects may last for over a decade aft...

12 Mars 202528min

Dose Optimisation in the ICU: The Role of TDM and Model-Based Solutions

Dose Optimisation in the ICU: The Role of TDM and Model-Based Solutions

5 Mars 202539min

A randomised controlled trial of a nurse facilitator to promote communication for family members of critically ill patients

A randomised controlled trial of a nurse facilitator to promote communication for family members of critically ill patients

Admission to the intensive care unit (ICU) can be a challenging experience for patients and their families. Psychological burdens, including symptoms of anxiety, depression and post-traumatic stress, ...

18 Dec 202422min

European Society of Intensive Care Medicine guidelines on end of life and palliative care in the intensive care unit

European Society of Intensive Care Medicine guidelines on end of life and palliative care in the intensive care unit

The latest guidelines released from the European Society of Intensive Care Medicine (ESICM) are about end-of-life (EOL) and palliative care for critically ill adults! This comprehensive work, develop...

11 Dec 20247min

Fluid management and mechanical ventilation strategies

Fluid management and mechanical ventilation strategies

Mechanical ventilation (MV) can impair gas exchange, destabilise hemodynamics, and injure endothelial cells. Intravenous (IV) fluid therapy helps to restore hemodynamics and ensure adequate distal org...

4 Dec 202423min

When and how vasopressors in Sepsis?

When and how vasopressors in Sepsis?

The early initiation of vasopressors, ideally within the first hour of diagnosing septic shock, is emerging as a preferred strategy. This approach offers a multimodal action with potential benefits, i...

20 Nov 202425min

Populärt inom Business & ekonomi

framgangspodden
varvet
rss-jossan-nina
badfluence
rss-borsens-finest
svd-tech-brief
rss-svart-marknad
bathina-en-podcast
uppgang-och-fall
avanzapodden
fill-or-kill
rss-inga-dumma-fragor-om-pengar
rss-dagen-med-di
lastbilspodden
tabberaset
kapitalet-en-podd-om-ekonomi
dynastin
rss-kort-lang-analyspodden-fran-di
rikatillsammans-om-privatekonomi-rikedom-i-livet
borsmorgon