101 | David Baltimore on the Mysteries of Viruses

101 | David Baltimore on the Mysteries of Viruses

I recently saw an estimate that if you took all the novel coronaviruses in the world (the actual viruses, not patients), you could fit them into a bucket no more than a couple of liters in volume. A huge impact has been wrought by a very small amount of stuff. The world of viruses is vast and complicated, and we're still learning some of its basic features. Today's guest David Baltimore won the Nobel Prize in Physiology or Medicine for the discovery that genetic information in viruses could flow from RNA to DNA, establishing an exception to the Central Dogma of Biology. He is the author of the Baltimore Classification scheme for viruses, and has done important research in the role of viruses in diseases from AIDS to cancer. We talk about what viruses are, how they work, and the status of the novel coronavirus we are currently battling. David also has some strong opinions about public health and how we should be preparing for future outbreaks.

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David Baltimore received his Ph.D. in molecular biology from the Rockefeller Institute. He is currently the Robert Andrews Millikan Professor of Biology at Caltech. At age 37 he was awarded the Nobel Prize, which he shared with Howard Temin and Renato Dulbecco. He has served as the President of both Rockefeller University and Caltech, as well as President of the American Association for the Advancement of Science and the Founding Director of the Whitehead Institute for Biomedical Research. Among his other awards are the National Medal of Science and the Warren Alpert Foundation Prize.


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62 | Michele Gelfand on Tight and Loose Societies and People

62 | Michele Gelfand on Tight and Loose Societies and People

Physicists study systems that are sufficiently simple that it's possible to find deep unifying principles applicable to all situations. In psychology or sociology that's a lot harder. But as I say at ...

2 Sep 20191h 12min

61 | Quassim Cassam on Intellectual Vices and What to Do About Them

61 | Quassim Cassam on Intellectual Vices and What to Do About Them

All of us have been wrong about things from time to time. But sometimes it was a simple, forgivable mistake, while other times we really should have been correct. Properties that systematically preven...

26 Aug 20191h 10min

60 | Lynne Kelly on Memory Palaces, Ancient and Modern

60 | Lynne Kelly on Memory Palaces, Ancient and Modern

Memory takes different forms. Memories can be encoded in the strength of neural connections in our brains, but there's a sense in which photographs and written records are memories as well. What did p...

19 Aug 20191h 15min

59 | Adam Becker on the Curious History of Quantum Mechanics

59 | Adam Becker on the Curious History of Quantum Mechanics

There are many mysteries surrounding quantum mechanics. To me, the biggest mysteries are why physicists haven't yet agreed on a complete understanding of the theory, and even more why they mostly seem...

12 Aug 20191h 40min

58 | Seth MacFarlane on Using Science Fiction to Explore Humanity

58 | Seth MacFarlane on Using Science Fiction to Explore Humanity

Fiction shines a light on the human condition by putting people into imaginary situations and envisioning what might happen. Science fiction expands this technique by considering situations in the fut...

5 Aug 20191h 12min

57 | Astra Taylor on the Promise and Challenge of Democracy

57 | Astra Taylor on the Promise and Challenge of Democracy

"Democracy may not exist, but we'll miss it when it's gone" — or so suggests the title of Astra Taylor's new book. We all know how democracy falls short, in practice, of its lofty ideals; but we can a...

29 Juli 20191h 23min

56 | Kate Adamala on Creating Synthetic Life

56 | Kate Adamala on Creating Synthetic Life

Scientists can't quite agree on how to define "life," but that hasn't stopped them from studying it, looking for it elsewhere, or even trying to create it. Kate Adamala is one of a number of scientist...

22 Juli 20191h 12min

55 | A Conversation with Rob Reid on Quantum Mechanics and Many Worlds

55 | A Conversation with Rob Reid on Quantum Mechanics and Many Worlds

As you may have heard, I have a new book coming out in September, Something Deeply Hidden: Quantum Worlds and the Emergence of Spacetime. To celebrate, we're going to have more than the usual number o...

15 Juli 20191h 26min

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