117 | Sean B. Carroll on Randomness and the Course of Evolution

117 | Sean B. Carroll on Randomness and the Course of Evolution

Evolution is a messy business, involving as it does selection pressures, mutations, genetic drift, and the effects of random external interventions. So in the end, how much of it is predictable, and how much is in the hands of chance? Today we're thrilled to have as a guest my evil (but more respectable, by most measures) twin, the biologist Sean B. Carroll. Sean is both a leader of the modern evo-devo revolution, and a wonderful and diverse writer. We talk about the importance of randomness and unpredictability in life, from the evolution of species to the daily routine of every individual.

Support Mindscape on Patreon.

Sean B. Carroll received a Ph.D. in immunology from Tufts University. He is currently the Andrew and Mary Balo and Nicholas and Susan Simon Endowed Chair of Biology at the University of Maryland, Vice-President for Science Education at the Howard Hughes Medical Institute, the Executive Director of HHMI Tangled Bank Studios, and Professor Emeritus of Genetics and Molecular Biology at the University of Wisconsin. His new book, A Series of Fortunate Events: Chance and the Making of the Planet, Life, and You, explores the role of chance in the development of life.


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88 | Neil Shubin on Evolution, Genes, and Dramatic Transitions

88 | Neil Shubin on Evolution, Genes, and Dramatic Transitions

"What good is half a wing?" That's the rhetorical question often asked by people who have trouble accepting Darwin's theory of evolution by natural selection. Of course it's a very answerable question...

16 Mars 20201h 33min

87 | Karl Friston on Brains, Predictions, and Free Energy

87 | Karl Friston on Brains, Predictions, and Free Energy

If you tell me that one of the world's leading neuroscientists has developed a theory of how the brain works that also has implications for the origin and nature of life more broadly, and uses concept...

9 Mars 20201h 29min

86 | Martin Rees on Threats to Humanity, Prospects for Posthumanity, and Life in the Universe

86 | Martin Rees on Threats to Humanity, Prospects for Posthumanity, and Life in the Universe

Anyone who has read histories of the Cold War, including the Cuban Missile Crisis and the 1983 nuclear false alarm, must be struck by how incredibly close humanity has come to wreaking incredible dest...

2 Mars 20201h 40min

85 | L.A. Paul on Transformative Experiences and Your Future Selves

85 | L.A. Paul on Transformative Experiences and Your Future Selves

It's hard to make decisions that will change your life. It's even harder to make a decision if you know that the outcome could change who you are. Our preferences are determined by who we are, and the...

24 Feb 20201h 14min

84 | Suresh Naidu on Capitalism, Monopsony, and Inequality

84 | Suresh Naidu on Capitalism, Monopsony, and Inequality

Nations generally want their economies to be rich, robust, and growing. But it's also important to person to ensure that wealth doesn't flow only to a few people, but rather that as many people as pos...

17 Feb 20201h 26min

83 | Kwame Anthony Appiah on Identity, Stories, and Cosmopolitanism

83 | Kwame Anthony Appiah on Identity, Stories, and Cosmopolitanism

The Greek statesman Demosthenes is credited with saying "I am a citizen of the world," and the idea that we should take a cosmopolitan view of our common humanity is a compelling one. Not everyone agr...

10 Feb 20201h 38min

82 | Robin Carhart-Harris on Psychedelics and the Brain

82 | Robin Carhart-Harris on Psychedelics and the Brain

The Convention on Psychotropic Substances was a 1971 United Nations treaty that placed strong restrictions on the use of psychedelic drugs — not only on personal use, but medical and scientific resear...

3 Feb 20201h 17min

81 | Ezra Klein on Politics, Polarization, and Identity

81 | Ezra Klein on Politics, Polarization, and Identity

People have always disagreed about politics, passionately and sometimes even violently. But in certain historical moments these disagreements were distributed without strong correlations, so that any ...

27 Jan 20201h 21min

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