5 | Geoffrey West on Networks, Scaling, and the Pace of Life

The Convention on Psychotropic Substances was a 1971 United Nations treaty that placed strong restrictions on the use of psychedelic drugs — not only on personal use, but medical and scientific research as well. Along with restrictions placed by individual nations, it has been very difficult for scientists to study the effects of psychedelics on the brain, despite indications that they might have significant therapeutic potential. But this has gradually been changing, and researchers like Robin Carhart-Harris have begun to perform controlled experiments to see how psychedelics affect the brain, and what positive uses they might have. Robin and I talk about how psychedelics work, how they can help with conditions from addiction to depression, and how they can help people discover things about themselves.Support Mindscape on Patreon.Robin Carhart-Harris received his Ph.D. in psychopharmacology from the University of Bristol. He is currently the Director of the Centre for Psychedelic Research in the Department of Brain Sciences at Imperial College London, and holds an honorary position at the University of Oxford. His research involves functional brain imaging studies with psilocybin (magic mushrooms), LSD, MDMA (ecstasy) and DMT (ayahuasca), plus a clinical trial of psilocybin for treatment-resistant depression.Web siteCentre for Psychedelic ResearchGoogle Scholar pageTalk on Psychedelics: Lifting the VeilTwitterSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Feb 20201h 17min

People have always disagreed about politics, passionately and sometimes even violently. But in certain historical moments these disagreements were distributed without strong correlations, so that any one political party would contain a variety of views. In a representative democracy, that kind of distribution makes it easier to accomplish things. In contrast, today we see strong political polarization: members of any one party tend to line up with each other on a range of issues, and correspondingly view the other party with deep distrust. Political commentator Ezra Klein has seen this shift in action, and has studied it carefully in his new book Why We’re Polarized. We talk about the extent to which the apparent polarization is real, how we can trace its causes, and whether there’s anything we can do about it.Support Mindscape on Patreon.Ezra Klein received a B.A. in political science from the University of California, Los Angeles. He is currently the editor-at-large and founder of Vox. As a writer and editor his work has appeared in/on The Washington Post, MSNBC, Bloomberg, The New York Review of Books, and The New Yorker. Among his awards are Blogger of the Year (The Week), 50 Most Powerful People in Washington DC (GQ), Best Online Commentary (Online News Association), and the Carey McWilliams Award (American Political Science Association).Vox profileThe Ezra Klein Show podcastWhy We’re PolarizedWikipediaTwitterSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Jan 20201h 21min

Physics is simple; people are complicated. But even people are ultimately physical systems, made of particles and forces that follow the rules of the Core Theory. How do we bridge the gap from one kind of description to another, explaining how someone we know and care about can also be “just” a set of quantum fields obeying impersonal laws? This is a hard question that comes up in a variety of forms — What is the “self”? Do we have free will, the ability to make choices? What are the moral and ethical ramifications of these considerations? Jenann Ismael is a philosopher at the leading edge of connecting human life to the fundamental laws of nature, for example in her recent book How Physics Makes Us Free. We talk about free will, consciousness, values, and other topics about which I’m sure everyone will simply agree.Support Mindscape on Patreon.Jenann Ismael received her Ph.D. in philosophy from Princeton University. She is currently Professor of Philosophy at Columbia University. Her work includes both the foundations of physics (spacetime, quantum mechanics, symmetry) and the philosophy of mind and cognition. She has been awarded fellowships from Stanford University, the Australian Research Council, the Scots Philosophical Association, and the Center for Advanced Study in Social and Behavioral Sciences, as well as an Essay Prize from the British Society for the Philosophy of Science.Web siteColumbia web pagePhilPeople profileAmazon author pageCloser to Truth interviewWikipedia“Well-Being and Time,” David Velleman (mentioned in the episode)See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Jan 20201h 26min

We are all alive, but “life” is something we struggle to understand. How do we distinguish a “living organism” from an emergent dynamical system like a hurricane, or a resource-consuming chemical reaction like a forest fire, or an information-processing system like a laptop computer? There is probably no one crisp set of criteria that delineates life from non-life, but it’s worth the exercise to think about what we really mean, especially as the quest to find life outside the confines of the Earth picks up steam. Sara Imari Walker planned to become a cosmologist before shifting her focus to astrobiology, and is now a leading researcher on the origin and nature of life. We talk about what life is and how to find it, with a special focus on the role played by information and computation in living beings.Support Mindscape on Patreon.Sara Imari Walker received her Ph.D. in physics from Dartmouth college. She is currently Associate Professor in the School of Earth and Space Exploration at Arizona State University, Deputy Director of the Beyond Center for Fundamental Concepts in Science, and Associate Director of the ASU-Santa Fe Institute Center for Biosocial Complex Systems. She is the co-founder of the astrobiology social network SAGANet, and serves on the Board of Directors for Blue Marble Space.Web siteGoogle Scholar pageAsk an Astrobiologist interviewTalk on A Theory of LifeWikipediaTwitterSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Jan 20201h 23min

Wilfrid Sellars described the task of philosophy as explaining how things, in the broadest sense of term, hang together, in the broadest sense of the term. (Substitute “exploring” for “explaining” and you’d have a good mission statement for the Mindscape podcast.) Few modern thinkers have pursued this goal more energetically, creatively, and entertainingly than Daniel Dennett. One of the most respected philosophers of our time, Dennett’s work has ranged over topics such as consciousness, artificial intelligence, metaphysics, free will, evolutionary biology, epistemology, and naturalism, always with an eye on our best scientific understanding of the phenomenon in question. His thinking in these areas is exceptionally lucid, and he has the rare ability to express his ideas in ways that non-specialists can find accessible and compelling. We talked about all of them, in a wide-ranging and wonderfully enjoyable conversation.Support Mindscape on Patreon.Daniel Dennett received his D.Phil. in philosophy from Oxford University. He is currently Austin B. Fletcher Professor of Philosophy and co-director of the Center for Cognitive Studies at Tufts University. He is known for a number of philosophical concepts and coinages, including the intentional stance, the Cartesian theater, and the multiple-drafts model of consciousness. Among his honors are the Erasmus Prize, a Guggenheim Fellowship, and the American Humanist Association’s Humanist of the Year award. He is the author of a number of books that are simultaneously scholarly and popular, including Consciousness Explained, Darwin’s Dangerous Idea, and most recently Bacteria to Bach and Back.Web siteBibliographyGoogle Scholar pageAmazon author pageWikipediaTalk on The Illusion of ConsciousnessCenter for Cognitive StudiesThe Clergy ProjectTwitterSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Jan 20202h 1min

Welcome to the second annual Mindscape Holiday Message! No substantive content or deep ideas, just me talking a bit about the state of the podcast and what’s on my mind. Since the big event for me in 2019 was the publication of Something Deeply Hidden, I thought it would be fun to talk about the process of writing and selling a popular book. Might be of interest to some of you out there!Mindscape takes off for the holidays, so the next regular episode will be published on Monday January 6. It’s a good one — maybe my favorite episode thus far.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Dec 20191h 6min

In the United States, more than one in five deaths is caused by cancer. The medical community has put enormous resources into fighting this disease, yet its causes and best treatments continue to be a puzzle. Azra Raza has been on both sides of the patient’s bed, as she puts it — both as an oncologist and expert in the treatment of Myelodisplastic Syndrome (MDS), and as a wife who lost her husband to cancer. In her new book, The First Cell, she argues that we have placed too much emphasis on treating cancer once it has already developed, and not nearly enough on catching it as soon as possible. We talk about what cancer is and why it’s such a difficult disease to understand, as well as discussing how patients and their loved ones should face up to the challenges of dealing with cancer.Support Mindscape on Patreon.Azra Raza received her M.D. from Dow Medical College in Karachi, Pakistan. She is currently Chan Soon-Shiong Professor of Medicine and Director of the MDS Center at Columbia University in New York. Previously she was the Chief of Hematology-Oncology and the Gladys Smith Martin Professor of Oncology at the University of Massachusetts. Her Tissue Repository contains over 60,000 samples of samples from MDS and acute leukemia patients. She is the co-editor of the celebrated blog site 3 Quarks Daily.Web siteColumbia University Medical Center pageFirst Cell CenterWikipediaThe First CellConversation With Siddhartha MukherjeeTwitterSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Dec 20191h 22min

It’s too easy to take laws of nature for granted. Sure, gravity is pulling us toward Earth today; but how do we know it won’t be pushing us away tomorrow? We extrapolate from past experience to future expectation, but what allows us to do that? “Humeans” (after David Hume, not a misspelling of “human”) think that what exists is just what actually happens in the universe, and the laws are simply convenient summaries of what happens. “Anti-Humeans” think that the laws have an existence of their own, bringing what happens next into existence. The debate has implications for the notion of possible worlds, and thus for counterfactuals and causation — would Y have happened if X hadn’t happened first? Ned Hall and I have a deep conversation that started out being about causation, but we quickly realized we had to get a bunch of interesting ideas on the table first. What we talk about helps clarify how we should think about our reality and others.Support Mindscape on Patreon.Edward (Ned) Hall received his Ph.D. in philosophy from Princeton University. He is currently Department Chair and Norman E. Vuilleumier Professor of Philosophy at Harvard University. According to his web page, “I work on a range of topics in metaphysics and epistemology that overlap with philosophy of science. (Which is to say: the best topics in metaphysics and epistemology.)” He is the coauthor (with L.A. Paul) of Causation: A User’s Guide.Web sitePhilPeople profileWikipediaDialogue on causation with Laurie PaulSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Dec 20191h 25min