Personal Genomics: Where Are We, Really?

"Incremental change may be good theory, but in practice you have to have a big enough stick to hit everybody with to make everything move at once". So shares Adrian Cockcroft, who helped lead Netflix'...

31 Aug 201627min

For better or worse, most of the computing systems that run much of our lives (whether invisibly or visibly) have become increasingly complex -- they're not fully engineered; they're almost grown. And...

30 Aug 201618min

Bitcoin quickly made its way from a whitepaper to a production network, which is pretty amazing when you think about it. But its scripting/ programming language was initially, intentionally, limited ...

28 Aug 201650min

Now that we know to price and plan early, price high -- especially for category-creating or "pre-chasm" businesses -- how do we handle freemium models? While free to premium is a great way to get bott...

19 Aug 201632min

"Raise prices." Regular listeners of our podcast have heard this advice more than once. But why is this so key and yet so hard for many technical founders? And how should startups go about raising pri...

14 Aug 201636min

This podcast is all about emoji. But it's really about how innovation really comes about -- through the tension between standards vs. proprietary moves; the politics of time and place; and the economi...

3 Aug 201638min

From hardware and hardwires to smartphones and social, technology wants to connect. It's almost a native property of technology and especially software businesses, which is why network effects matter....

1 Aug 201621min

Seemingly overnight, a single game -- Pokémon Go -- has taken people by storm. But it's a game that was technically years in the making, building on a legacy of creative intellectual property and tech...

22 Juli 201635min