Paul Saladino MD podcast8 Sep 2020

69. What’s to blame for Insulin Resistance, Carbs or PUFAs? A very friendly debate with Ben Bikman, PhD

Benjamin Bikman earned his PhD in Bioenergetics and was a postdoctoral fellow with the Duke-National University of Singapore studying metabolic disorders. Currently, his professional focus as a scientist and professor (Brigham Young University) is to better understand the origins and consequences of metabolic disorders, including obesity and diabetes, with a particular emphasis on the role of insulin. He frequently publishes his research in peer-reviewed journals and presents at international science and public meetings.

Time Stamps

0:11:14 Podcast Begins

0:11:54 Ben's Background

0:17:53 The root of chronic disease

0:25:38 All about insulin

0:31:14 Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification https://www.semanticscholar.org/paper/Regulation-of-free-fatty-acid-metabolism-by-insulin-Campbell-Carlson/9be324b8af9ced5a8b7e1902257e3fb9308b4db1

0:31:51 Insulin stops lipolisis

0:34:35 Insulin's affect on the liver

0:40:10 Insulin and muscle cells

0:43:20 Why you want to increase protein as you age

0:48:47 Low Protein Intake is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988204/#:~:text=Low%20Protein%20Intake%20is%20Associated,Younger%20but%20Not%20Older%20Population&text=Cell%20Metab.,Author%20manuscript.

0:51:00 Animal-based diets optimize muscle protein sythesis

0:55:12 Industrial Seed oils have a fantastic publicist

0:58:05 Do carbs drive metabolic dysfunction?

1:07:07 Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man https://link.springer.com/article/10.1007/BF00400466

1:07:42 How linoleic acid drives metabolic dysfunction

1:09:32 How linoleic acid drives metabolic dysfunction.

1:11:47 Low serum insulin in traditiona

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