9. Dave Feldman and Siobhan Huggins return for the ULTIMATE lipid podcast, the roots of insulin resistance, hs-CRP and Lp(a)

On this week’s podcast, Paul sits down with former football player, retired American professional mixed martial artist, former Director of Human Optimization at Onnit and host of The Kyle Kingsbury Podcast, Kyle Kingsbury. They do a a deep dive into ideals that Paul is passionate about, and Kyle interviews Paul about the truth behind seed oils, cholesterol, weight loss, and more controversial topics. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:07:37 Podcast begins 00:18:42 The benefits of cholesterol  00:24:22 Paul’s LDL while eating a Carnivore diet 00:28:57 Honey versus processed sugar 00:37:07 Thoughts on satiety & linoleic acid/HNE 00:48:27 Seed oils and endogenous cannabinoids 01:09:22 The connection between seed oils & cardiovascular disease/macular degeneration? 01:21:57 Detoxing seed oils and HNE 01:23:57 Thoughts on alcohol and tobacco 01:32:07 Creating an intentional environment 01:34:27 What causes insulin resistance? 01:38:22 Thoughts on carbohydrates and insulin resistance 01:43:57 Are some seed oils/fats better than others? 01:55:27 Wrapping things up Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Bon Charge: https://boncharge.com, use code CARNIVOREMD for 15% off your order or get 25% off site wide until 11/30 Colima Salt: drpaulsalt.com, for a free bag of Colima Sea Salt Higher Dose: www.higherdose.com/paul, or use code PAUL for 15% off your order

27 Nov 20221h 58min

This week, Paul interviews board certified cardiologist, Michael Twyman. Michael comments on Paul’s blood lipids and they both chat about apoB, cardiovascular risks, oxidized LDL, and, of course, seed oils. They both share what they believe the true indicators of cardiovascular risk really are, aside from LDL.  A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:01:25 Podcast begins 00:04:15 Interpreting Paul’s labs 00:10:05 ApoB particles & atherosclerosis/endothelial dysfunction 00:27:09 The insulin resistance pandemic 00:30:49 Do we all need Statins? 00:36:59 Integrative cardiology 00:40:24 The importance of nitric oxide 00:45:39 The problems with glyphosate 00:47:20 Thoughts on seed oils 00:56:39 Lp-PLA2 test 00:58:39 Lipoprotein (a) & endothelial dysfunction 01:11:59 Mitochondrial health 01:16:21 How to take care of our hearts Connect with Dr. Twyman: @drtwyman on Instagram drtwyman.com Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Marek Health: ma

21 Nov 20221h 29min

This week, Paul interviews his good friend and board certified family physician with a focus on prevention and optimisation care, Ken Berry. They indulge in a healthy conversation about ketogenic versus animal-based diets, views on carbohydrates and honey, and the concept of bio-individuality when it comes to the optimal diet for humans. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:09:25 Podcast begins 00:10:59 Ken’s bloodwork 00:14:44 How does Ken Berry define metabolic health? 00:34:49 Ken’s thoughts on seed oils 00:42:24 Ken and Paul’s differing thoughts on carbohydrates and fruit 01:15:14 The ancestral consistency of fruit and honey 01:31:34 Should people from different regions eat different diets? 01:56:44 The individualization of medical care and nutrition 01:58:44 The importance of organs Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Colima Salt: drpaulsalt.com, for a free bag of Colima Sea Salt Higher Dose: www.higherdose.com/paul, or use code PAUL for 15% off your order Bon Charge: https://boncharge.com, use code CARNIVOREMD for 15% off your order

15 Nov 20222h 5min

Today, Paul interviews Tucker Goodrich, Wall Street technology extraordinaire and independent researcher, and Jeff Nobbs, co-founder and CEO of Zero Acre Farms. They take a deep dive into the epidemic of seed oil consumption. They examine conflicting arguments, and then explain why seed oils are likely making humans fat, diabetic, and causing atherosclerosis. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:08:14 Podcast begins 00:13:55 What are seed oils and why are they bad for us? 00:23:30 Ancestral consistency of seed oils and linoleic acid 00:42:40 How are seed oils processed? 00:51:40 Should we worry about trans fats? 00:56:40 Let’s talk about HNE and PUFAs 01:13:10 Endocannabinoids 01:30:40 Are seed oils inflammatory? 00:01:43 Diverticulosis 01:47:20 Seed oils & blindness 01:48:45 Closing remarks about linoleic acid Connect with Jeff: zeroacre.com jeffnobbs.com Connect with Tucker: yelling-stop.blogspot.com Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Our Sponsor LetsGetChecked: 20% off your order at www.TRYLGC.com/paulsaladino for 25% off  Marek Health: marekhealth.com/fundamentalhealth, use code PAUL for 10% off your first lab order

8 Nov 20221h 56min

In today’s episode, Paul addresses longevity in terms of how his views differ from those in the longevity community that promote eating less meat and more vegetables. He touches on mTOR, leucine, methionine, and glycine, and ultimately answers the question of: Will an animal-based diet improve our vitality, but decrease our longevity? A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:08:59 Podcast begins 00:10:57 David Sinclair on longevity 00:12:10 What does mainstream medicine say about red meat & longevity? 00:14:00 What does the longevity community recommend as an ideal diet? 00:30:27 What are mice fed in most animal studies? 00:34:07 Why we don’t need to fear mTOR 00:40:17 Thoughts on leucine 00:50:27 Should we restrict our methionine intake?  00:56:57 Studies on the benefits of eating meat 1:00:37 The evolutionary consistency of an animal-based diet Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org   White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Colima Salt: drpaulsalt.com, for a free bag of Colima Sea Salt Higher Dose: www.higherdose.com/paul, or use code PAUL for 15% off your order Our Sponsor LetsGetChecked: Go to https://trylgc.com/paulsaladino and use code PAULSALADINO for 25% off

31 Okt 20221h 5min

Tommy Wood makes his third appearance on Paul’s podcast to cover a wide range of topics. Tommy is a developmental neuroscientist and professor of pediatrics and neuroscience at University of Washington. In today’s podcast, Paul and Tommy chat about overall brain health and dementia, lipids, LDL, continuous glucose monitors, and seed oils. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:07:36 Podcast begins 00:10:25 Should we eat animal brain? 00:17:40 Debunking misconceptions about Alzheimer's & APOE4 00:26:55 Saturated fat & APOE4 00:32:15 Tommy’s thoughts on insulin resistance & linoleic acid 00:44:30 Tommy’s thoughts on the ”calories in, calories out” weight loss model 01:00:50 A better model for understanding Alzheimer’s & brain health 01:16:20 Blue zones and thoughts on retirement 1:22:05 Critical nutrients for brain health Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Marek Health: marekhealth.com/fundamentalhealth, use code PAUL for 10% off your first lab order Colima Salt: drpaulsalt.com, for a free bag of Colima Sea Salt Bon Charge: https://boncharge.com, use code CARNIVOREMD for 15% off your order

24 Okt 20221h 31min

On today's podcast, Paul talks about how diabetes is diagnosed, how it’s treated by mainstream medicine, what he believes it is caused by, and how you can reverse your diabetes or pre-diabetes without medication. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:07:33 Podcast begins 00:11:33 Mainstream recommendations for diabetes 00:20:25 Metabolic health of American adults 00:24:45 What causes diabetes? 00:30:03 The problems with linoleic acid 00:36:25 Diabetes physiology 00:46:30 HNE & Linoleic acid 00:52:00 Thoughts on olive oil 01:06:00 Type 1 Diabetes  Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Our Sponsor LetsGetChecked: Go to https://trylgc.com/paulsaladino and use code PAULSALADINO for 25% off Colima Salt: drpaulsalt.com, for a free bag of Colima Sea Salt Higher Dose: www.higherdose.com/paul, or use code PAUL for 15% off your order

18 Okt 20221h 11min

Are plant defense chemicals real? Are they a problem for humans? Paul addresses these questions in today’s podcast along with why he believes they are harmful for many people at a molecular level. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:06:16 Podcast begins 00:09:15 What are plant defense chemicals? 00:16:50 An anecdote on removing vegetables and switching to animal-based 00:19:05 Animal and plant warfare  00:24:50 Vegetables through an anthropological lens 00:30:40 The effects of plant compounds on the gut 00:33:00 Debunking any benefits of vegetables in our diet 00:42:35 Plant compounds have negative side effects  00:46:14 The harmful effects of oxalates and other plant defense chemicals 1:00:30 The problem with lectins 1:08:30 Plants do not want to be eaten Link to Sal’s Story about healing through Animal-based eating: https://www.youtube.com/watch?v=gp13WsEL7P8 Hormetic stress: The benefit of SAUNA vs. broccoli: https://www.youtube.com/watch?v=DvKgXnKYfd0 Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Marek Health: marekhealth.com/fundamentalhealth, use code PAUL for 10% off your first lab order Colima Salt: drpaulsalt.com, for a free bag of Colima Sea Salt Bon Charge: https://boncharge.com, use code CAR

10 Okt 20221h 10min