9. Dave Feldman and Siobhan Huggins return for the ULTIMATE lipid podcast, the roots of insulin resistance, hs-CRP and Lp(a)

9. Dave Feldman and Siobhan Huggins return for the ULTIMATE lipid podcast, the roots of insulin resistance, hs-CRP and Lp(a)

If you are interested in lipids, you’ve probably heard of Dave Feldman and his work. If not, you’ve got some homework to do, and I think you’ll be amazed at what you find. Dave’s work can found at cholesterolcode.com where he details his multiple, meticulous self-experimental projects. Prior to cholesterol adventures Dave was a senior software scientist and an engineer. He brings this “out of the box” thinking to the world of medicine and we are all better off for it.

He began a low-carb, high-fat diet in April 2015 and has since learned everything he could about it with special emphasis on cholesterol. He saw his own lipid numbers spike substantially after going on the diet and spotted a pattern in the lipid system that’s very similar to distributed objects in networks.

He’s since learned quite a bit on the subject both through research and experimentation which has revealed some very powerful data. Where he induced a 73 point drop in my LDL-C and a 1115 point drop in my LDL-P.

Siobhan (she'-VAUN) Huggins is an independent researcher focused on lipidology, the immune system, and metabolic diseases. She spends most of her time at cholesterolcode.com where she works alongside Dave Feldman. She has been keto since August of 2016, and on a predominantly carnivorous diet as of October 2017. She has lost 80 lbs, reversed hypertension, and found a passion for research along the way.

5:47 Dave Feldman's blood testing at low carb San Diego

7:17 The Feldman Protocol

9:39 Does it matter whether subjects are a ketogenic vs. carbohydrate based metabolism 11:19 What labs were administered?

13:03 Shevawn(Siobhan??) on the inflammatory markers.

14:09 What's the sense of the half-life of HSCRP?

18:09 Ferritin

22:34 Other Markers being tested?

25:29 Glucagon

27:17 is it expected from these labs to find free fatty acids in the blood ?

29:23 What do you use as a cutoff for high fasting insulin?

30:00: C-Peptide

32:55 Hemaglobin A1C

34:37 Test frequency/pitfalls of looking at tests in isolation.

38:09 The Lipid Panel ,(triglycerides)

42:42 How are Triglycerides different from free fatty acids?

45:22 Measuring Triglycerides. What Happens to triglycerides after eating a high fat Carnivore meal?

50:13 Any utility to non-fasted lipid panels ?

50:52 Will triglycerides be higher on a Ketogenic diet (postprandially)

51:39 difference in postprandial triglycerides between Keto and carbohydrate based metabolisms.

54:14 Recommendations around Triglycerides.

58:32 What else elevates triglycerides?

1:01:39 Thoughts on Coffee

1:04:56 National Health and Nutritional Survey.

1:06:49 How many people are in this data set?

1:08:15 What is linear regression?

1:11:58 Why Dave wanted to look at all cause mortality.

1:13:52 Ldl and all cause mortality

1:14:57 Age parity

1:16:37 "The Dave Dance"

1:17:52 Critique:diseases that bring down LDL.

1:20:59 What epidemiology is useful for.

123:32 What happened when those who died within 10 years.

1:23:22 How many people ended up in the age parity subset?

1:25:20 How could LDL be good for you?

1:31:57 Evolutionary role of insulin resistance.

Avsnitt(328)

223. Oatmeal is NOT a health food

223. Oatmeal is NOT a health food

Have you been led to believe that oatmeal is good for you? This podcast is for you! Paul does a deep dive on why you may want to cut oats (and chocolate, and leafy greens) out for good for reasons like heavy metal accumulation, antinutrients, and defense chemicals. 00:07:30 The problem with grains 00:11:45 Heavy metals in oats, greens, chocolate and fish 00:20:00 How saponins damage the gut 00:31:30 Cadmium and heavy metals in oats, vegetables and chocolate  00:48:15 Phytic acid 00:49:20 Pesticides in your oats 00:50:50 Mold contamination in grains 00:53:00 Takeaways on oats References: Influence of saponins on gut permeability and active nutrient transport in vitro: https://www.semanticscholar.org/paper/Influence-of-saponins-on-gut-permeability-and-in-Johnson-Gee/b100e152961fa3beb84c676ac0ae43e74b52af9e Reducing the damage of quinoa saponins on human gastric mucosal cells by a heating process: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977518/ Triterpenoid Saponins in Oat Bran and Their Levels in Commercial Oat Products: https://figshare.com/collections/Triterpenoid_Saponins_in_Oat_Bran_and_Their_Levels_in_Commercial_Oat_Products/5002223 The biological action of saponins in animal systems: a review: https://pubmed.ncbi.nlm.nih.gov/12493081/ Effect of oat saponins and different types of dietary fibre on the digestion of carbohydrates: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-oat-saponins-and-different-types-of-dietary-fibre-on-the-digestion-of-carbohydrates/95992869AEC98CFAB161548C043F93E7 Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparations in vitro: https://pubmed.ncbi.nlm.nih.gov/20650190/ A major gene for grain cadmium accumulation in oat (Avena sativa L.): https://www.researchgate.net/publication/6204970_A_major_gene_for_grain_cadmium_accumulation_in_oat_Avena_sativa_L Toxicity of cadmium and its health risks from leafy vegetable consumption:https://www.researchgate.net/publication/313975727_Toxicity_of_cadmium_and_its_health_risks_from_leafy_vegetable_consumption Ideal Cereals With Lower Arsenic and Cadmium by Accurately Enhancing Vacuolar Sequestration Capacity: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467212/ Cadmium Levels in Soils and Crops in the United States: https://www.semanticscholar.org/paper/Cadmium-Levels-in-Soils-and-Crops-in-the-United-Chang-El-Amamy/18c4415de7340ae4b30ac9516c1acae4c4ed6300 Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org Bon Charge: boncharge.com, use code CARNIVOREMD for 15% off your order Zero Acre: www.zeroacre.com/PAUL or use code PAUL for free shipping on your first order Earth Runners: www.earthrunners.com, use code CARNIVORE for 10% off your order

11 Juli 202357min

222. Are Snickers bars fruit? With Aaron Alexander

222. Are Snickers bars fruit? With Aaron Alexander

Today’s episode features Paul on the Align podcast with Aaron Alexander.  They chat about a plethora of topics, beginning with cholesterol, touching on seed oils, testicular health, sweeteners, and endocrine disrupting chemicals along the way, and ending with a conversation about the importance of social and mental health. 00:07:45 Podcast begins 00:10:00 Clarifying the cholesterol conversation 00:29:45 Hadza diet & movement patterns 00:34:00 Seed oils lowering LDL & the Statin conversation 00:42:40 Testicular health & forever chemicals 00:51:50 Endocrine disrupting chemicals 01:08:20 The importance of social & mental health 01:20:50 Intuitive eating & meat substitutes 01:32:00 Thoughts on different kinds of sweeteners 01:44:30 Canola oil 01:47:45 Why do we fear the sun? 01:56:50 Thoughts on olive oil Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org Zero Acre: www.zeroacre.com/PAUL or use code PAUL for free shipping on your first order Joovv Light Therapy: http://joovv.com/paul, use code PAUL for an exclusive discount Sacred Hunting: sacredhunting.com/PAUL, get $250 off your hunt Marek Health: https://marekhealth.com/fundmental-health-collection/, or use code PAUL for 10% off your first lab order and check out Paul’s custom blood panel

4 Juli 20232h 2min

221. How to optimize sleep

221. How to optimize sleep

Paul’s episode today is all about sleep. He touches on substances like caffeine, alcohol, and marijuana, how grounding may impact circadian rhythms,  and you’ll get an inside look at Paul’s morning and nighttime routine. 00:09:00 How we view sleep as a society 00:10:30 REM versus nonREM sleep 00:15:30 How much sleep is enough sleep? 00:19:50 Sleeping more = earning more? 21:50 Less sleep = less attractive? 00:25:35 Sleep for athletics and learning 00:27:40 How much/when to sleep 00:31:50 Paul’s sleep routine 00:46:45 Coffee, alcohol and marijuana’s effect on sleep 00:50:07 How to troubleshoot your sleep 00:52:00 Sleep supplements 00:54:40 Blue light’s effect on sleep 00:58:15 Grounding & sleep References: https://iristech.co/ Time Use and Productivity: The Wage Returns to Sleep: https://ideas.repec.org/p/wil/wileco/2015-17.html Partial sleep deprivation reduces natural killer cell activity in humans: https://pubmed.ncbi.nlm.nih.gov/7871104/ Deep Sleep Gives Your Brain a Deep Clean: https://www.scientificamerican.com/article/deep-sleep-gives-your-brain-a-deep-clean1/ Negative effects of restricted sleep on facial appearance and social appeal: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451790/ Blocking nocturnal blue light for insomnia: A randomized controlled trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703049/ Smartphone viewing distance and sleep: An experimental study utilizing motion capture technology: https://www.researchgate.net/publication/314716943_Smartphone_viewing_distance_and_sleep_An_experimental_study_utilizing_motion_capture_technology Amber lenses to block blue light and improve sleep: a randomized trial: https://pubmed.ncbi.nlm.nih.gov/20030543/ Perception of Sleep Disturbances due to Bedtime Use of Blue Light-Emitting Devices and Its Impact on Habits and Sleep Quality among Young Medical Students: https://www.hindawi.com/journals/bmri/2019/7012350/ Blue light from light-emitting diodes elicits a dose-dependent suppression of melatonin in humans: https://pubmed.ncbi.nlm.nih.gov/21164152/ The Biologic Effects of Grounding the Human Body During Sleep as Measured by Cortisol Levels and Subjective Reporting of Sleep, Pain, and Stress: https://www.researchgate.net/publication/8081857_The_Biologic_Effects_of_Grounding_the_Human_Body_During_Sleep_as_Measured_by_Cortisol_Levels_and_Subjective_Reporting_of_Sleep_Pain_and_Stress Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  Schwank Grills: schwankgrills.com, use code PAUL150 for $150 off a Schwank 1500 degree grill Earth Runners: www.earthrunners.com, use code CARNIVORE for 10% off your order Eight Sleep: $150 off the PodPro cover at www.eightsleep.com/carnivoremd Bon Charge: boncharge.com, use code CARNIVOREMD for 15% off your order

26 Juni 20231h

220. Is plant-based dead? Paul Saladino MD on Radical Health Radio

220. Is plant-based dead? Paul Saladino MD on Radical Health Radio

This week’s podcast features Paul as a guest on Radical Health Radio, the Heart and Soil podcast at the headquarters in Dripping Springs, Texas. Paul talks to the show host, Ste Lane, about vegan and plant based diets: the risks, benefits, and the popularity in a high-level way. 00:07:00 Podcast begins 00:12:12 Is plant-based popular? 00:17:40 The plant-based agenda 00:20:45 The ethics of eating animals 00:28:00 How veganism affects libido 00:34:15 The politics behind veganism 00:46:00 The problem with seed oils  00:50:30 Which diet is best for humans? 00:59:00 Escaping dogma 01:01:22 Paul’s future goals and self care practices 01:11:00 Live caller #1: Tips on how to read and understand studies better 01:18:20 Live caller #2: Will HDL keep rising on an animal-based diet? 01:26:00 Live caller #3: What kinds of foods to give a 5 month old? 01:35:00 Upcoming documentary Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  Bon Charge: boncharge.com, use code CARNIVOREMD for 15% off your order Zero Acre: www.zeroacre.com/PAUL or use code PAUL for free shipping on your first order Joovv Light Therapy: http://joovv.com/paul, use code PAUL for an exclusive discoun Eight Sleep: $150 off the PodPro cover at www.eightsleep.com/carnivoremd

19 Juni 20231h 37min

219. Grounding: Does it work? With Clint Ober

219. Grounding: Does it work? With Clint Ober

Today’s podcast episode is a deep dive on grounding. Paul has on Clint Ober, CEO of EarthFX Inc., author, and innovator behind the grounding movement to talk about the ancestral consistency, overall benefits, and science behind grounding and how it relates to modern disease and inflammation. 00:10:30 High level: what is grounding? 00:20:00 Electron explanation 00:27:40 Positive vs. negative charge 00:35:35 Voltage and amperage 00:41:50 Physics, grounding and inflammation 00:55:20 Oxidation and reduction of inflammation 01:22:30 How much should humans be grounding? References: https://earthinginstitute.net/ Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  Animal-based 30 Challenge: https://heartandsoil.co/animalbased30/ Earth Runners: www.earthrunners.com, use code CARNIVORE for 10% off your order Marek Health: marekhealth.com/fundamentalhealth, use code PAUL for 10% off your first lab order Sacred Hunting: sacredhunting.com/PAUL, get $250 off your hunt Zero Acre: www.zeroacre.com/PAUL or use code PAUL for free shipping on your first order

12 Juni 20231h 35min

218. Could seed oils make you blind? With Chris Knobbe

218. Could seed oils make you blind? With Chris Knobbe

This week, Paul chats with ophthalmologist and M.D., Chris Knobbe. They continue the conversation about seed oils and they reference observational research to further their point that it is the number one contributor to chronic illness and macular degeneration over sugar. 00:07:10 Who is Chris Knobbe? 00:09:30 Macular degeneration 00:16:30 How seed oils affect macular degeneration 00:25:00 Carboxymethyl pyrrol 00:32:10 Linoleic acid levels now versus our ancestors 00:40:00 How to avoid seed oils 01:00:00 Cardiolipin 01:07:30 The problem with studies on linoeic acid 01:14:00 Sugar vs. seed oils References:  Book: The Ancestral Diet Revolution by Chris Knobbe Website: https://www.cureamd.org/ Dietary fatty acids and the 10-year incidence of age-related macular degeneration: the Blue Mountains Eye Study: https://pubmed.ncbi.nlm.nih.gov/19433717/ Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  Animal-based 30 Challenge: https://heartandsoil.co/animalbased30/ Sacred Hunting: sacredhunting.com/PAUL, get $250 off your hunt Marek Health: https://marekhealth.com/fundmental-health-collection/, or use code PAUL for 10% off your first lab order and check out Paul’s custom blood panel

6 Juni 20231h 28min

217. How to lose weight

217. How to lose weight

This week, Paul is re-sharing a popular episode about how to lose weight, healthily. He first speaks on how not to lose weight and why he believes the mainstream paradigm for weight loss is flawed. He dives into what he believes makes humans fat in the first place, actionable steps to take for weight loss including how to increase satiety, and why “calories in calories out” is an outdated and oversimplified method. 00:09:00 Podcast begins 00:12:45 How not to lose weight 00:14:55 What is a “Westernized diet?” 00:15:55 Why would you want to lose weight? 00:16:55 The importance of improving the quality of your diet instead of counting calories 00:23:15 Why do we get fat? 00:27:20 How to increase satiety and the problem with seed oils 00:43:35 Nutrient adequacy and satiety  00:49:05 Raw versus pasteurized dairy 00:53:25 Studies on meat-based diets and weight loss  Sponsors: Heart & Soil: www.heartandsoil.co Sign up for Animal Based Gathering 2023: animalbasedgathering.com  Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  Schwank Grills: schwankgrills.com, use code PAUL150 for $150 off a Schwank 1500 degree grill Earth Runners: www.earthrunners.com, use code PAUL for 10% off your order Colima Salt: drpaulsalt.com, for a free bag of Colima Sea Salt Bon Charge: boncharge.com, use code CARNIVOREMD for 15% off your order

30 Maj 20231h 6min

216. Should you worry about high cholesterol? With Aseem Malhotra

216. Should you worry about high cholesterol? With Aseem Malhotra

This week, Paul chats with cardiologist, public health campaigner and author, Aseem Malhotra. They touch on pharmaceuticals, statins, and whether LDL cholesterol is a big deal. They also provide tools to assess your metabolic health and stress levels in an objective manner. 00:09:38 Podcast begins 00:10:38 What sparked Aseem’s interest in the root of disease 00:12:58 Big Pharma’s influence on dietary guidelines 00:16:23 The story of sugar 00:24:48 Fear of cholesterol 00:40:58 Statins 01:01:08 The power of positive lifestyle changes References: https://www.nopharmfilm.com/ https://twitter.com/DrAseemMalhotra https://www.instagram.com/lifestylemedicinedoctor/ Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality: An Individual-Level Pooled Analysis of 30 Cohort Studies: https://sci-hub.se/10.1161/CIRCULATIONAHA.118.038908 Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  Marek Health: https://marekhealth.com/fundmental-health-collection/, or use code PAUL for 10% off your first lab order and check out Paul’s custom blood panel Joovv Light Therapy: http://joovv.com/paul, use code PAUL for an exclusive discount Eight Sleep:  www.eightsleep.com/carnivoremd for exclusive Memorial Day savings now through June 6th

22 Maj 20231h 19min

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