Immunopeptidomics Offer New Hope in Cancer Research

In this episode of omgOMX, enter the world of immunopeptidomics with University of Oxford’s Associate Prof. Nicola Ternette. Nicola shares her humble beginnings in virology to becoming a leading expert in the field of immunology. Discover how mass spectrometry opened new doors for protein analysis and vaccine development how Nicola's lab is revolutionizing cancer therapy by profiling immune molecules in different diseases, and how this information can be used to direct clinical applications

Don't miss this inspiring episode that showcases the power of women in science and the potential of immunopeptidomics to shape the future of cancer therapies. Hit that subscribe button and share this episode with fellow science enthusiasts!

00:21 - Nicola's humble beginnings in virology, shaping her path to where she is today

05:48 - Moving to the UK and her exposure to mass spectrometry at Benedict Kessler's proteomics facility

07:43 - Working on HIV vaccines with experts to understand how infected cells appear to the immune system

09:02 - Specializing in profiling immune molecules in diseases and cancer to inform vaccine development

10:00 - The breakthrough realization of applying immune system knowledge to cancer research

10:18 - Focusing on mechanistic research and profiling specific antigens for potential clinical applications

11:29 - Collaboration with industry for cancer therapies and the importance of automation in research

13:09 - Automating the process for analyzing broader sample cohorts and optimizing sample acquisition

14:42 - The challenge of high-throughput analysis and the future of immunopeptidomics

16:38 - The significance of validation in mass spectrometry workflows and antigen identification

21:15 - The impact of the pandemic on vaccine research and its role in cancer therapy

23:53 - Optimism about future advancements in immunopeptidomics and cancer immunotherapy

27:56 - Surprising discoveries and expanding collaborations in industry and clinical partnerships

30:32 - Balancing personal and professional life as an academic researcher

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