Neuro Podcases3 Dec 2024

Neurodevelopmental disorders with Prof. Michele Jacob

In the fourth episode of our Neuroscience Research series, hosts Filippo Dall'Armellina and Dr. Michael Cearns are joined by Prof. Michele Jacob, Professor of Neuroscience at Tufts University. Prof. Jacob’s research focuses on autism spectrum disorders, intellectual disabilities, and the molecular mechanisms underlying neurodevelopmental disorders. Her work spans basic biology, including the Wnt/β-catenin signalling pathway, as well as electrophysiological studies and preclinical mouse models. Together, we discuss groundbreaking evidence for therapeutic interventions targeting conditions such as autism spectrum disorder and the rare CTNNB1 syndrome. Research Highlights from the Episode: - Paper 1: Alexander JM, et al. Excessive β-Catenin in Excitatory Neurons Results in Reduced Social and Increased Repetitive Behaviors and Altered Expression of Multiple Genes Linked to Human Autism. Front Synaptic Neurosci. 2020 Mar 31; PMID: 32296324. - Paper 2: Alexander JM, et al. Inhibition of GSK3α,β Rescues Cognitive Phenotypes in a Preclinical Mouse Model of CTNNB1 Syndrome. EMBO Mol Med. 2024 Sep; PMID: 39103699. 🧠 #NeuroscienceResearch X/Twitter: @NPodcases Visit the Neuro Podcases website: neuropodcases.co.uk

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Avsnitt(84)

Essential Neurosurgery for the MLA - Functional Neurosurgery

Essential Neurosurgery for the MLA - Functional Neurosurgery by Neuro Podcases

8 Maj 17min

Essential Neurosurgery for the MLA - Spinal

Essential Neurosurgery for the MLA - Spinal by Neuro Podcases

1 Maj 25min

Essential Neurosurgery for the MLA - Intracerebral haemorrhage

In this episode we are joined by Mr Nick Carleton-Bland to discuss the topic of ICH

24 Apr 24min

Essential Neurosurgery for the MLA - Cranial

In this episode with are joined by Mr Nick Carleton-Bland to discuss some of the essential cranial Neurosurgery topics relevant to the UK Medical Licensing exam (MLA).

17 Apr 18min

Inside Rett syndrome with Prof. Nicoletta Landsberger

In episode seven of our Neuroscience Research series, Filippo Dall'Armellina and Dr. Michael Cearns speak with Dr. Nicoletta Landsberger from the University of Milan. Her research focuses on Rett synd...

11 Aug 202542min

Genetic risk factors for Alzheimer's disease with Prof. Julie Williams

In this episode of our Neuroscience Research series, Filippo Dall'Armellina and Dr Michael Cearns speak with Professor Julie Williams (Cardiff University), a leading figure in the genetics of Alzheime...

27 Juni 202537min

Genetic Causes of ALS/FTD with Prof. Isaacs

In this episode of our Neuroscience Research series, hosts Filippo Dall'Armellina and Michael Cearns welcome Professor Adrian Isaacs (UCL), who investigates the molecular and cellular mechanisms under...

27 Feb 202533min